Schiff bass
1
3-oxazepine and antibacterial activity
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In this research , phthallic anhydride ring is opened with 4-methyl aniline and acetone as a
solvent to results the compound [I] that reacted with dimethyl sulphate and anhydrous sodium
carbonate formation to phathalate ester [II], while the acid hydrazide compound [III], was
obtained from mixed the compound [II]with hydrazine hydrate, Synthesis four type of shiff
bases[IV]a-d was synthesized from the reaction of acid hydrazide [III] with aromatic aldehyde
or ketone , when reacted Shiff bases with phthalic anhydride or naphthalicanhydride,I get
eight derivatives of oxazepine [V]a-d , [VI]a-d. The bacterial activity of the new compounds
studied by four species of bacteria: Esherichia Coli, Enterobactecloacae (Gram negative) and
staphylococcu
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