The objective of this study was to develop neural network algorithm, (Multilayer Perceptron), based correlations for the prediction overall volumetric mass-transfer coefficient (kLa), in slurry bubble column for gas-liquid-solid systems. The Multilayer Perceptron is a novel technique based on the feature generation approach using back propagation neural network. Measurements of overall volumetric mass transfer coefficient were made with the air - Water, air - Glycerin and air - Alcohol systems as the liquid phase in bubble column of 0.15 m diameter. For operation with gas velocity in the range 0-20 cm/sec, the overall volumetric mass transfer coefficient was found to decrease with increasing solid concentration. From the experimental work 1575 data points for three systems, were collected and used to predicate kLa. Using SPSS 17 software, predicting of overall volumetric mass-transfer coefficient (kLa) was carried out and an output of 0.05264 sum of square error was obtained for trained data and 0.01064 for test data.