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D-dimer and Ferritin Levels in Prediction of COVID-19 Severity
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Abstract<sec> <title>BACKGROUND:

The most common cause of upper respiratory tract infection is coronavirus, which has a crown appearance due to the existence of spikes on its envelope. D-dimer levels in the plasma have been considered a prognostic factor for COVID-19 patients.

AIM OF THE STUDY:

The aim of the study is to demonstrate the role of COVID-19 on coagulation parameters D-dimer and ferritin with their association with COVID-19 severity and disease progression in a single-center study.

PATIENTS AND METHODS:

This study included 200 COVID-19 patients in a private single center from January 01, 2021, to January 01, 2022, in Baghdad-Iraq. D-dimer and ferritin were analyzed in those patients and evaluated their association with the need for oxygen therapy and intensive care unit (ICU) admission.

RESULTS:

Two hundred COVID-19 patients met the criteria for inclusion in this research. The total mean age of all patients was 60.1 ± 11.6 years and the sex distribution was 130 (65%) males and 70 (35%) females. Regarding D-dimer and ferritin, there were significantly higher values in patients in respiratory care units (4748 ± 7.2) (215.7 ± 4.2) (P = 0.0001) in comparison with another group who did not need oxygen or ICU admission (345 ± 3.6) (98.4 ± 1.7), respectively.

CONCLUSIONS:

High levels of D-dimer and ferritin may be used as tools to predict unfavorable clinical outcomes of the disease and poor prognosis.

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