The utilization and incorporation of glass fiber-reinforced plastics (GFRP) in structural applications and architectural constructions are progressively gaining prominence. Therefore, this paper experimentally and numerically investigates the use of GFRP I-beams in conjunction with concrete slabs to form composite beams. The experimental design incorporated 2600 mm long GFRP I-beams which were connected compositely to concrete slabs with a 500 mm width and 80 mm thickness. The concrete slabs are categorized into two groups: concrete slabs cast using normal-strength concrete (NSC), and concrete slabs prepared using high-strength concrete (HSC). Various parameters like the type of concrete (normal and high-strength concrete), type of stiffeners bonded to the composite section (bolt–epoxy or bolt only), and inclusion of corrugated metal sheets were investigated. To obtain the full shear connection between the GFRP I-sections and concrete slabs, two rows of shear connectors in the form of bolts were utilized. These shear connectors were erected to the top flange of the GFRP I-sections to compositely connect between the GFRP I-beams and the concrete slabs as well as the corrugated metal sheets. The strengthening of the shear webs of GFRP I-beams with GFRP T-section stiffeners resulted in an enhancement in the flexural and shear strength. The failure loads in the case of the bolt–epoxy connection for the stiffeners were 8.2% and 10.0% higher than those in the case of bolt only when the concrete compressive strengths were 20.1 MPa and 52.3 MPa, respectively. Moreover, the effect of the concrete compressive strength was vital where the failure loads increased by 79.9% and 77.1% when HSC was used instead of NSC for the cases of bolt–epoxy and bolt only, respectively. The epoxy adhesive used in conjunction with mechanical connectors, specifically bolts, resulted in sufficient composite action and delayed shear failure within the web of the GFRP beam. For the specimens with bolt–epoxy connection, strain levels in the concrete slabs were consistently higher than in the other specimens with bolts alone at the same loading level. The concrete slabs integrated with HSC registered strain levels that were 20.0% and 21.8% greater for bolt–epoxy and bolt-only connections, respectively, when compared to those using normal-strength concrete (NSC). This discrepancy can likely be credited to the enhanced composite interaction between the concrete slabs and the GFRP I-beams. In addition, ABAQUS software (version 6.2) was used to develop FE models to analyze the tested composite beams and provide a parametric study using the verified models.