Preferred Language
Articles
/
_uZ2k5wBmraWrQ4dpUsr
Solubility and Dissolution Rate Enhancement of Bilastine by Solid Dispersion Technique
...Show More Authors

Bilastine (BLS) is non-sedating new-brand H1 antihistamine that has selective peripheral effects, the drug has a problem of an insufficient aqueous solubility and accordingly low dissolution rate, and low bioavailability. Solid dispersion (SD) is one of the most effective techniques for improving the solubility and the dissolution rate of poorly soluble drugs by the dispersion of drug within an inert hydrophilic carrier.   The aim of this study is to increase the solubility and dissolution rate of the BLS using SD technique. Twenty-nine BLS SD formulas were prepared using different carrier polymers include Pluronic 407 (Poloxamer407), Poloxamer188, Urea, Polyethylene glycol 6000 (PEG6000) and Polyvinylpyrrolidone (PVP K30) and employing two different preparation methods (solvent evaporation and kneading method) at different drug: polymer ratios (1:1 ,1:3,1:5,1:10,1:15). The prepared SD formulas were evaluated for their percent yield, drug content, aqueous solubility, dissolution rate, PXRD, and FTIR. The SD technique successfully improved the solubility and dissolution rate of BLS. The improvement was largely dependent on the polymer type and drug: polymer ratio. The solubility improvement using different polymers was in the following order: PVP K30> PLX188> PEG6000> Urea> PLX407. The solid dispersion formula that showed the best outcomes in terms of dissolution improvement was prepared using the solvent evaporation technique employing PVP K30 at ratio of drug: polymer of 1:15. The optimized formula showed 10.2 folds increment in the solubility compared to pure BLS. It can be concluded that the SD technique can successfully improve the solubility and dissolution rate by solvent evaporation method with careful selection of the carrier polymer and drug: polymer ratio.

Scopus Crossref
View Publication
Publication Date
Wed Apr 29 2026
Journal Name
Journal Of Tikrit University For Humanities
The Dialogic Reading Technique on Iraqi EFL University Learners' Literacy Skills and Story Comprehension
...Show More Authors

Literary texts do not usually reflect English as a means of communication. The failure to read literary texts becomes the central concern in the study of language learning and teaching. Literary texts may lead adult readers to an ambiguous understanding due to having multiple interpretations. The current study aims at finding out the effect of the dialogic reading technique within teaching method on Iraqi EFL university learners according to the dimensions of literacy skills: operational, cultural, and critical and according to tasks of story comprehension: knowledge graph construction, fact-retrieval, and prompt formulation. A pretest-posttest design with control group of quasi-experimental study method to fulfill the objectives of this st

... Show More
View Publication Preview PDF
Publication Date
Sun Jun 20 2021
Journal Name
Baghdad Science Journal
A Comprehensive Review on Medical Image Steganography Based on LSB Technique and Potential Challenges
...Show More Authors

The rapid development of telemedicine services and the requirements for exchanging medical information between physicians, consultants, and health institutions have made the protection of patients’ information an important priority for any future e-health system. The protection of medical information, including the cover (i.e. medical image), has a specificity that slightly differs from the requirements for protecting other information. It is necessary to preserve the cover greatly due to its importance on the reception side as medical staff use this information to provide a diagnosis to save a patient's life. If the cover is tampered with, this leads to failure in achieving the goal of telemedicine. Therefore, this work provides an in

... Show More
View Publication Preview PDF
Scopus (17)
Crossref (9)
Scopus Clarivate Crossref
Publication Date
Sat Oct 20 2018
Journal Name
Journal Of Economics And Administrative Sciences
Using Multivariate GARCH Models CCC (Constant Conditional Correlation) and DCC(Dynamic Conditional Correlation) To Forecast Iraqi Dinar Exchange Rate in Dollar
...Show More Authors

Abstract

Multivariate GARCH Models take several forms , the most important DCC dynamic conditional correlation, and CCC constant conditional correlation , The Purpose of this research is the Comparison for both Models.Using three  financial time series which is a series of daily Iraqi dinar exchange rate indollar, Global daily Oil price in dollar and Global daily gold price in dollarfor the period from 01/01/2014 till 01/01/2016, Where it has been transferred to the three time series returns to get the Stationarity, some tests were conducted including Ljung-Box , JarqueBera  , Multivariate ARCH to Returns Series and Residuals Series for both models In Comparison

... Show More
View Publication Preview PDF
Crossref (1)
Crossref
Publication Date
Mon Mar 08 2021
Journal Name
Baghdad Science Journal
Monitoring of Defects Concentration in Deformed Aluminum Using Doppler Broadening Technique
...Show More Authors

Doppler broadening of the 511 keV positron annihilation ??? ? was used to estimate the concentration of defects ?? different deformation levels of pure alnminum samples. These samples were compressed at room temperature to 15, 22, 28, 38,40, and 75 % thickness reduction. The two-state ^sitron-trapping model has been employed. 'I he s and w lineshape parameters were measured using high-resolution gamma spectrometer with high pure germanium detector of 2.1 keV resolution at 1.33 MeV of 60Co. The change of defects concentration (Co) with the deformation level (e) is found to obey an empirical formula of the form Cd - A £ B where A and ? are positive constants that depend mainly on the deformation procedure and the temperature at which the def

... Show More
View Publication Preview PDF
Publication Date
Wed Nov 02 2011
Journal Name
Journal Of Engineering
Implementation of Gypseous Soil-asphalt Stabilization Technique for Base Course Construction
...Show More Authors

The aim of this research work is to study the effect of stabilizing gypseous soil, which covers vast areas in the middle, west and south parts of Iraq, using liquid asphalt on its strength properties to be used as a base course layer replacing the traditional materials of coarse aggregate and broken stones which are scarce at economical prices and hauling distances. Gypseous soil brought from Al-Ramadi City, west of Iraq, with gypsum content of 66.65%, medium curing cutback asphalt (MC-30), and hydrated lime are used in this study. The conducted tests on untreated and treated gypseous soil with different percentages of medium curing cutback asphalt (MC-30), water, and lime were: unconfined compression strength, and one dimensional confine

... Show More
Publication Date
Mon Jun 01 2015
Journal Name
Journal Of Engineering
Construction of Graduation Certificate Issuing System Based on Digital Signature Technique
...Show More Authors

With the development of computer architecture and its technologies in recent years, applications like e-commerce, e-government, e-governance and e-finance are widely used, and they act as active research areas. In addition, in order to increase the quality and quantity of the ordinary everyday transactions, it is desired to migrate from the paper-based environment to a digital-based computerized environment. Such migration increases efficiency, saves time, eliminates paperwork, increases safety and reduces the cost in an organization. Digital signatures are playing an essential role in many electronic and automatic based systems and facilitate this migration. The digital signatures are used to provide many services and s

... Show More
View Publication Preview PDF
Publication Date
Fri Jan 01 2016
Journal Name
Lap Lambert Academic Publishing
New Technique to Estimate the concentration of Heavy Metals in soil
...Show More Authors

There are many aims of this book: The first aim is to develop a model equation that describes the spread of contamination through soils which can be used to determine the rate of environmental contamination by estimate the concentration of heavy metals (HMs) in soil. The developed model equation can be considered as a good representation for a problem of environmental contamination. The second aim of this work is to design two feed forward neural networks (FFNN) as an alternative accurate technique to determine the rate of environmental contamination which can be used to solve the model equation. The first network is to simulate the soil parameters which can be used as input data in the second suggested network, while the second network sim

... Show More
View Publication Preview PDF
Publication Date
Thu Jul 01 2021
Journal Name
Periodicals Of Engineering And Natural Sciences (pen)
A proposed encryption technique of different texts using circular link lists
...Show More Authors

View Publication
Scopus (5)
Scopus Crossref
Publication Date
Tue Sep 01 2020
Journal Name
Acta Polytechnica
COMPLEXITY REDUCTION OF CYCLOSTATIONARY SENSING TECHNIQUE USING IMPROVED HYBRID SENSING METHOD
...Show More Authors

In cognitive radio system, the spectrum sensing has a major challenge in needing a sensing method, which has a high detection capability with reduced complexity. In this paper, a low-cost hybrid spectrum sensing method with an optimized detection performance based on energy and cyclostationary detectors is proposed. The method is designed such that at high signal-to-noise ratio SNR values, energy detector is used alone to perform the detection. At low SNR values, cyclostationary detector with reduced complexity may be employed to support the accurate detection. The complexity reduction is done in two ways: through reducing the number of sensing samples used in the autocorrelation process in the time domain and through using the Slid

... Show More
View Publication
Scopus (9)
Crossref (7)
Scopus Clarivate Crossref
Publication Date
Sat Oct 01 2011
Journal Name
Journal Of Engineering
IMPLEMENTATION OF GYPSEOUS SOIL-ASPHALT STABILIZATION TECHNIQUE FOR BASE COURSE CONSTRUCTION
...Show More Authors

The aim of this research work is to study the effect of stabilizing gypseous soil, which covers
vast areas in the middle, west and south parts of Iraq, using liquid asphalt on its strength properties
to be used as a base course layer replacing the traditional materials of coarse aggregate and broken
stones which are scarce at economical prices and hauling distances.
Gypseous soil brought from Al-Ramadi City, west of Iraq, with gypsum content of 66.65%,
medium curing cutback asphalt (MC-30), and hydrated lime are used in this study.
The conducted tests on untreated and treated gypseous soil with different percentages of medium
curing cutback asphalt (MC-30), water, and lime were: unconfined compression strength, and o

... Show More
View Publication Preview PDF
Crossref (3)
Crossref