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The current study was designed to investigate the effect of Tilletia smut spores on
histopathological changes in liver and kidney in mice. Twenty animals were divided into two equal
groups, 10 mice each, control group fed on normal diet and the treated groups were fed on a
mixture of 50% normal diet with 50% wheat infected with Tilletia for 30 days. Histopathological
sections taken from liver and kidney treated with Tilletia revealed several alterations. The changes
in liver included, multiple granulomatous lesions, area of coagulation necrosis, vacuolar
degeneration in the cytoplasm of hepatocytes, proliferation of hepatocytes with formation of
pseudolobull which initiates for procancer. Whereas in the kidney, the changes included
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