Non-steroidal anti-inflammatory drugs (NSAIDs) contain free –COOH which thought to be responsible for the GI irritation associated with all traditional NSAIDs. The esterification of this group is one of an approach to ultimate aim for reduce the gastric irritation; so in this study we synthesized and preliminarily evaluated new ester compounds as new analogues with expected selectivity toward COX-2 enzyme. Synthetic procedures have been successfully developed for the generation of the target compounds (III a and b). The synthetic approach involved multi-steps procedures which include: Synthesis of 4-hydroxy benzene sulphonamide ( I b ), synthesis of Naproxen and Ibuprofen acyl chloride and then reacting them with 4-hydroxy benzene sulphonamide to form final compounds ( III a-b) .The structures of these compounds were identified and characterized using (TLC), infrared spectroscopy (FT-IR), 1H NMR data and microanalysis (CHN).Pharmacological study as anti-inflammatory activities for the final compounds were studied in rats by induced edema type of inflammation. Moreover, the results of a docking study of compounds III a-b into the COX-2 binding site revealed that its mechanism was possibly similar to that of naproxen, a COX-2 inhibitor. The effect of them on COX-2 antibody was showed it could significantly inhibit COX-2 activity.
In dealing with media management phenomenon, concept and elements, we have tried, as much as possible, to build an abstract concept that can be analyzed and measured by analyzing the elements and components of the concept mentioned and explain it.
Before further consideration of the management of media campaigns, it is necessary to restore some points of media management so as not to understand the subject of campaign management as if it is independent of the concept of media management and the objectives that we seek to ensure its achievement. As we have noted that the concept of media management frames the administration mentioned as:
- Authority to manage the media institution.
- Operations supervised by the me
... Show MoreBackground: Gingival recession is defined as the apical migration of the gingival margin below the cementoenamel junction (CEJ), resulting in exposure of the root surface and it is one of the main esthetic complaints of patients. The management of gingival recession and its sequelae is based on a thorough assessment of the etiological factors and the degree of tissue involvement.
This research aims to deal with contemporary knowledge methodology to correlate between operations strategy and technological change or modernization in productive paths for industrial organizations depend on practical indicators for competitive priorities that is objectives of operations performance.
The research is based on main hypothesis, concentrates on determination of technological change which is decided by the level of technology deterioration in current operations path compared with the competitors leaders-technology leaders.
We apply these concepts on hypothetical case to two similar companies in their production nature and te
... Show MoreTo track scientific developments and achievements, for example, that (achieved) after the Second World War until this moment, make each of us in absolute amazement. He invented the computer, discovered the genetic factor (DNA), and discovered the drawing of the human genetic map, going up to the moon, penetrating outer space by satellites, getting close to distant planets, producing jet planes, microprocessors, and lasers, in addition to enabling a person to create a layer of The material is extremely thin and extremely imaginative. It has also become possible for a person to "dig lines that do not exceed 20 billion meters of thickness." The human being was also able to collect things an atom and build an efficient and high-precision con
... Show MoreDuring the course of fixed orthodontic therapy, patients should be instructed to eat specific food stuffs and beverages in order to maintain good health for the dentition and supporting structures and prevent frequent attachment debonding that prolong the treatment duration. After searching and collecting articles from 1930 till July 2021, the current review was prepared to emphasize various types of foods that should be taken during the course of fixed orthodontic therapy and to explain the effect of various food stuffs and beverages on the growth and development of craniofacial structures, tooth surfaces, root resorption, tooth movement, retention and stability after orthodontic treatment and the effect on the components of fixed ortho
... Show MoreBackground: Hypertension and dyslipidemia are
cardiovascular risk factors that commonly coexist .
Objective : To evaluate the effects of ß - blocker
(Atenolol) , ACE inhibitor (Captopril) calcium Channel
blocker (Nefidipin ) and diuretics on serum lipid profiles .
Method: Thirty untreated hypertensive and 147
hypertensive patient treated with these antihypertensive
drugs, attending different public health clinics in Basrah
pronivce were enrolled in this study .
Serum lipid profile were determined enzymaticaly using kits
from BioMerieux, France .
Result : The study has revealed that ß-blocker do not
significantly affect total cholesterol ( TC ) and LDLcholesterol , but increase significantly triglycer
Background: Dyslipidemia is a major cause of
cardiovascular disease, which in turn, is the most
common cause of female morbidity and mortality.
Postmenopausal women (natural and surgical) are at
higher risk of developing cardiovascular disease,
especially coronary artery atherosclerosis.
Objective: To observe the relationship between blood
lipids: total cholesterol (TC), high density lipoproteincholesterol (HDL-C), low density lipoproteincholesterol (LDL-C), triglycerides (TGs), and very low
density lipoprotein- cholesterol (VLDL-C), LDL-C/
HDL-C ratio (atherogenic index) and menopausal
status, and to determine the co-factors that may explain
this relationship
Methods: A prospective, cross-sectional st
Abstract
Currently, the “moderate discourse and civil peace” represents a rich and important topic for scholars, due the rise of waves of extremism and Islamophobia campaigns, and what that leads to in term of imbalance in relations between nations and peoples.
Based on that, the research approach was to tackle the culture of hatred and calls for the clash of civilizations.
In order to contribute to solving these problems caused by cultural and religious prejudices, I decided to address the topic of “moderate discourse and civil peace” through two essential axes:
- Features of moderate religious discourse
- The role of moderate discourse in establishing communit
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