The spectrum of clinical efficacy of Methotrexate (MTX) is broad in that MTX is used in the treatment of certain cancers, severe psoriasis and rheumatoid arthritis.Various mechanisms by which cancer cells grown in tissue culture become resistant to anticancer drugs. The use of multiple  drugs with different mechanisms of entry into cells and different cellular targets allows for effective chemotherapy and high cure rates. In an efforts to develop effective strategies that increase the therapeutic potential of anticancer drugs with less systemic toxicity ,are being directed  towards the investigation of dietary supplements and other phytotherapeutic agents for their synergistic efficacy in combination with anticancer drugs. A promi

     In this article, we investigate a mathematical fractional model of tuberculosis that takes into account vaccination as a possible way to treat the disease. We use an in-host tuberculosis fractional model that shows how Macrophages and Mycobacterium tuberculosis interact to knowledge of how vaccination treatments affect macrophages that have not been infected. The existence of optimal control is proven. The Hamiltonian function and the maximum principle of the Pontryagin are used to describe the optimal control. In addition, we use the theory of optimal control to develop an algorithm that leads to choosing the best vaccination plan. The best numerical solutions have been discovered using the forward and backward fractional Euler

     The spatial assessment criteria system for hybridizing renewable energy sources, such as hybrid solar-wind farms, is critical in selecting ideal installation sites that maximize benefits, reduce costs, protect the environment, and serve the community. However, a systematic approach to designing indicator systems is rarely used in relevant site selection studies. Therefore, the current paper attempts to present an inclusive framework based on content validity to create an effective criteria system for siting wind-solar plants. To this end, the criteria considered in the related literature are captured, and the top 10 frequent indicators are identified. The Delphi technique is used to subject commonly used factors to expert judgme

Granular carbon can be used after conventional filtration of suspended matter or, as a combination of filtration - adsorption medium. The choice of equipment depends on the severity of the organic removal problem, the availability of existing equipment, and the desired improvement of adsorption condition.
Design calculations on dechlorination by granular - carbon filters considering the effects of flow rate, pH , contact time, head loss and bed expansion in backwashing , particle size, and physical characteristics were considered assuming the absence of bacteria or any organic interface .

     The aim of this paper is to study the quaternary classical continuous optimal control for a quaternary linear parabolic boundary value problems(QLPBVPs). The existence and uniqueness theorem of the continuous quaternary state vector solution  for the weak form of the QLPBVPs with given quaternary classical continuous control vector (QCCCV)  is stated and proved via the Galerkin Method. In addition, the existence theorem of a quaternary classical continuous optimal control vector governinig by the QLPBVPs is stated and demonstrated. The Fréchet derivative for the cost function is derived. Finally, the necessary conditions for the optimality theorem  of the proposed problem is stated and  demonstrated.

The physical substance at high energy level with specific circumstances; tend to behave harsh and complicated, meanwhile, sustaining equilibrium or non-equilibrium thermodynamic of the system. Measurement of the temperature by ordinary techniques in these cases is not applicable at all. Likewise, there is a need to apply mathematical models in numerous critical applications to measure the temperature accurately at an atomic level of the matter. Those mathematical models follow statistical rules with different distribution approaches of quantities energy of the system. However, these approaches have functional effects at microscopic and macroscopic levels of that system. Therefore, this research study represents an innovative of a wi

Background: Asthma is one of the most common chronic respiratory diseases in the world, standing for the most frequent cause for hospitalization and emergency cases. Respiratory viruses are the most triggering cause. Aim: To assess the role of viral infections, especially COVID-19, in the pathogenesis of asthma initiation and exacerbations. Method: Electronic search was done for the manuscripts focusing on asthma as a risk factor for complications after COVID-19 infection. The outcomes were titles, materials, methods and classified studies related or not related to the review study. Three hundred publications were identified and only ten studies were selected for analysis. Seven studies were review, one retrospective, one longitudin

Background: Nursing interventions tailored to the smoking triggers in patients with non-communicable chronic diseases are essential. However, these interventions are scant due to the nature of factors associated with smoking cessation and the poor understanding of the effect of nurse-led intervention in Iraq.Purpose: This study aimed to determine the dominant smoking triggers and examine the effects of a tailored nursing intervention on smoking behavior in patients with non-communicable chronic diseases.Methods: Convenience samples of 128 patients with non-communicable chronic diseases, male and female patients, who were 18-70 years old, were recruited in this quasi-experimental, randomized comparative trial in the outpatient clinic