The study aimed to assess the expression of CD49d and CD26 in newly diagnosed CLL patients and find their correlation with clinical Binet stage, and other clinical parameters. This study was conducted on 51 newly diagnosed CLL patients based on lymphocyte count > 5×109/L and immunophenotyping. The expression of CD49d, and CD26 were investigated using eight-color flow cytometer. The expression of CD49d and CD26 were detected in 56.9 %, 68.8 % of CLL patients, respectively. The correlation between CD49d expression and CD26 expression was statistically significant (p < 0.001) with high concordance rate between them. The positive expression of both CD49d and CD26 had statistically significant association with clinical Binet staging (p < 0.001, and 0.001, respectively) and their combined positive expression had also statistically significant association with clinical Binet stage of the disease (p < 0.001) with the highest combined positive rate was associated with stage C then followed by B in comparison with stage A. Conclusion: Positive CD49d and CD26 expressions were significantly correlated with advanced clinical Binet stage and associated with frequent lymphadenopathy and their combined positive expression had highly significant correlation with advanced clinical Binet stage and therefore their co expression could be beneficial as reliable prognostic indicator in CLL patients.
Back ground: Peripheral neuropathy is a common complication of diabetes mellitus. However, patients with diabetes are more vulnerable to develop chronic inflammatory demyelinating peripheral polyradiculoneuropathy (CIDP) which is an acquired immune mediated disorder.
Subjects and methods: Three groups of subjects of either sex involved in this study; fourty one (41) patients with diabetic CIDP, fourty six (46)patients with diabetic peripheral polyneuropathy and fourty one (41) control subjects. Sensory and motor nerve conduction study (NCS) and electromyography (EMG) of both upper and lower limbs were performed for each subjects. This study was cond
... Show MoreThe focus of this research revolves around the importance level of sialic acid in the reasoning of cases, including tumors and then evaluate the patient's response to treatment and its impact on the immune response there are a lot of evidence showing that parts Alkrbu ???????? in peptides sugary and glycoproteins play an important role in Alfalitin life and responsiveness
Correlation of Serum levels of Chromium, Copper, and Manganese with the Glucose levels in Type 2 Diabetes Mellitus in Ira
Background: The metabolism of many trace elements such as chromium, copper, and manganese were reported to be altered in type 2 diabetes militates. This element may have specific roles in the pathogenesis and progress of this disease.
Objectives: To evaluate the serum levels of copper, chromium, and manganese in type 2 diabetic patients in Iraq.
Patients and Methods: This case-control study included 100 type 2 diabetic patients, 35-60 years old, with high BMI as cases, and 100 non-diabetic subjects as controls who were healthy
... Show MoreBackground: Diabetes mellitus (DM) could be regarded as a set of chronic metabolic disorders which have a common aspect of hyperglycemia. The resistance in the peripheral actions of insulin or impaired insulin secretion could be the reason hepcidin which is a peptide hormone derived from liver, in systemic iron homeostasis is an essential regulator, and its lopsided production participates in the pathogenesis of iron disorders in spectrum. Osteoporosis often accompanies many diseases like ß-thalassemia, hemochromatosis, sickle liver diseases, cell disease and hemosiderosis featured by iron overload, evidences suggest that Iron overload and iron deficiency are suggested by evidences that they affec
... Show MoreIn order to study the correlation between CMV infection and increase in blood pressure among Iraqi patients, 201 blood samples were collected including; 88 male, 113 female hypertensive patients and 40 control samples. Patients sera were grouped into patients who are under medication (T), and patients who do not take any treat-ment for hypertension(NT). Samples were tested for CMV-IgM/IgG by ELISA, ren-in enzyme and interleukin-6(IL-6) levels were determined by ELISA too. The opti-cal density readings difference for CMV-IgG were significant between (T) and (NT) groups as well as when each group compared to control, level of renin enzyme showed significant difference between patients group(T and NT) and between each group compared to the
... Show MoreUrinary Tract Infection is an infection that caused by the members of the genus
Proteus that depends mainly on the availability of virulence factors ;Various
virulence factors including biofilm, swarming migration , polysaccharide
,heamolysin,protease, DNase, urease production weredetermined for 45Proteus
isolates that obtained from clinical specimens of Urinry Tract Infection patient .
The distribution of virulence factors was showed variation among the testedisolates
and strain specific in most cases. All Proteus isolates showed 45 (100%)biofilm ,
polysaccharide andSwarming capabilities with different extents. High
ureaseproduction was demonstrated in most isolates 40 (88.8%);In addition, they
were abling to
Background: Maxillary sinusitis is one of the most common infections of humans. Sinusitis can be defined as an inflammation of the membrane lining of any sinus, especially one of the
paranasal sinuses.
Objective: To determine the causative microorganisms of chronic maxillary sinusitis.
Patients: Forty five chronic sinusitis patients were involved in the present study.
Methods: Sampling method were sinus specimens (aspiration or injection aspiration).
Results: Haemophilus species, Streptococcus pneumoniae (S.pneumoniae) and Moraxella catarrhalis (M.catarrhalis) were the most frequent isolates; in addition Penicillium and
Cladosporium species were isolated from some chronic sinusitis patients.
Conclusion: Chr
Background: Chronic gastritis (CG) is histopathological entity characterized by chronic inflammation of the stomach that mostly caused by Helicobacter pylori, development of
inflammation in gastric mucosa result in release of pro- and anti- inflammatory cytokines .This study aimed to shed light on the role of cytokines (IFN-γ, IL-8, IL-4, IL-10, and GM-CSF) in the
development and prognosis of CG among Iraqi patients.
Patients and methods: 100 Iraqi patients with CG (61 male and 39 female) with age range (10-79) year, were involved in this stady while attending Specialist Hospital of Disease of Liver and Gastrointestinal System at Baghdad Medical City from Nov. 2007 to Apr. 2008. Patients divided accordi