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Impact of MDR-1 Gene Polymorphism (rs1128503) on Response to Imatinib or Nilotinib in Iraqi Patients with Chronic Myeloid Leukemia: An Observational Study
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Background: There is a significant molecular response to imatinib given at standard doses in individuals with chronic myeloid leukemia (CML) whose ABCB1 polymorphisms are present. Objective: To investigate the impact of the polymorphism in the ABCB1 gene rs1128503 on the effectiveness of nilotinib or imatinib therapy. Methods: From May 2022 until the end of January 2023, the current study was carried out in a single research institution, the National Center of Hematology, Baghdad Teaching Hospital at Medical City, Iraq. 76 people with chronic phase myeloid leukemia (CML-CP), who had previously received a diagnosis using the European Leukemia Net (ELN) criteria, enrolled in the trial. The PCR product was delivered to Macrogen Corporation, Korea, for Sanger sequencing on an automated DNA sequencer, the ABI3730XL. After receiving the results by email, Geneious Prime software was used for analysis. Results: Patients receiving imatinib or nilotinib did not differ significantly in terms of age or gender. In contrast, BCR-ABL1 transcript levels were considerably greater at sampling in patients receiving nilotinib. Different types of the MDR-1 gene rs1128503 genotype were not found in groups that were treated with either imatinib or nilotinib. Conclusions: BCR-ABL1 transcript levels are lower in patients still receiving imatinib than in those receiving nilotinib.

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Publication Date
Sun Feb 09 2025
Journal Name
Journal Of Baghdad College Of Dentistry
Early detection of periodontitis among young adult cigarette smokers and non-smokers using cone beam computed tomography
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Background: Periodontitis is an inflammatory disease that affects the supporting tissues of the teeth; Smoking is an important risk factor for periodontitis induces alveolar bone loss and cause an imbalance between bone resorption and bone deposition. The purpose of this study is to detect and compare the presence of incipient periodontitis among young smokers and non-smokers by measuring the distance between cement-enamel junction and alveolar crest (CEJ-Ac) using Cone Beam Computed Tomography (CBCT). Material and methods: The total sample composed of fifty two participants, thirty one smokers and twenty one non-smokers (age range 14-22 years). Periodontal parameters: plaque index (PLI), gingival index (GI) were recorded for all teeth exc

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Publication Date
Wed Jan 20 2021
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Using Entropy and Linear Exponential Loos Function Estimators the Parameter and Reliability Function of Inverse Rayleigh Distribution
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     This paper is devoted to compare the performance of non-Bayesian estimators represented by the Maximum likelihood estimator of the scale parameter and reliability function of inverse Rayleigh distribution with Bayesian estimators obtained under two types of loss function specifically; the linear, exponential (LINEX) loss function and Entropy loss function, taking into consideration the informative and non-informative priors. The  performance of such estimators assessed on the basis of mean square error (MSE) criterion. The Monte Carlo simulation experiments are conducted in order to obtain the required results. 

 

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Publication Date
Fri Mar 01 2024
Journal Name
Baghdad Science Journal
First Transition Metal Complexes Salts of Diazonium Derived from Nitrogen Heterocyclic Compound, Synthesis, Characterization and Biological Activity
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Metal complexes chrome(III), manganese(II), iron(III), cobalt(II), nickel(II), cupper(II) and zinc(II) with diazonium of 3-amino-2-chloropyridine of general formula [2-Cl-C5H3N≡N]n[MXm], where n=2 or 3 for divalent and trivalent metal, m= 4 or 6  were synthesized. The complexes have been characterized by flame atomic absorption, (C.H.N), molar conductance, magnetic susceptibility UV-vis spectra, infrared spectra,1H-NMR spectroscopy and thermo gravimetric analysis (TGA and DTA). The measurements showed that the divalent metal ion complexes (M2+) have (1:2) M:L ratio with tetrahedral geometry around metal ions while the trivalent metal ions (M3+) formed (1:3) m

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Publication Date
Wed Jun 30 2021
Journal Name
International Journal Of Research In Medical Sciences & Technology
GREEN SYNTHESIS OF SILVER NANOPARTICLE USING GREEN TEA LEAVES EXTRACT FOR REMOVAL CIPROFLOXACIN (CIP) FROM AQUEOUS MEDIA
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This study examines the removal of ciprofloxacin in an aqueous solution using green tea silver nanoparticles (Ag-NPs). The synthesized Ag-NPs have been classified by the different techniques of SEM, AFM, BET, FTIR, and Zeta potential. Spherical nanoparticles with average sizes of 32 nm and a surface area of 1.2387m2/g are found to be silver nanoparticles. The results showed that the ciprofloxacin removal efficiency depends on the initial pH (2.5-10), CIP (2-15 mg/L), temperature (20-50°C), time (0-180 min), and Ag-NPs dosage (0.1-1g/L). Batch experiments revealed that the removal rate with ratio (1:1) (w/w) were 52%, and 79.8% of the 10 mg/L of CIP at 60, and 180 minutes, respectively with optimal pH=4. Kinetic models for adsorpti

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Publication Date
Fri Apr 30 2021
Journal Name
Iraqi Journal Of Science
The Suitability of Tigris River Sediments from Tikrit, Northern Iraq, for Concrete Production and Road Construction Purposes
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This study aims to assess the suitability of the sediments present in Tigris River, Tikrit city, northern Iraq for concrete production and road building purposes. Representative samples were collected from three selected stations at the study area using the channel modeling method. According to the grain size analysis, the sediments were classified as a type of poorly graded gravels (GP) depending on the unified soil classification system. The true specific gravity of the soil ranged between 2.28 and 2.568. The chemical analysis of the study samples revealed that gypsum content ranged between 0.82 and 1.69 %. Total soluble salts ranged 2.45- 3.87%, the organic matter content ranged 0.14- 0.76%, and the pH value was between 7.73 and 7.38%

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Publication Date
Wed Jul 06 2022
Journal Name
Future Oncology
The first Middle East and North Africa expert consensus recommendations for the management of advanced colorectal cancer
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Publication Date
Mon Aug 16 2021
Journal Name
Indian Journal Of Forensic Medicine & Toxicology
Statistic Assessment of Spreading Cases (Total Confirmed, Recovered, Death) From Different AreasContain Novel Coronavirus (2019-n Cov)
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Publication Date
Mon Jan 01 2024
Journal Name
Open Engineering
Using ANN for well type identifying and increasing production from Sa’di formation of Halfaya oil field – Iraq
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Abstract<p>The current study focuses on utilizing artificial intelligence (AI) techniques to identify the optimal locations of production wells and types for achieving the production company’s primary objective, which is to increase oil production from the Sa’di carbonate reservoir of the Halfaya oil field in southeast Iraq, with the determination of the optimal scenario of various designs for production wells, which include vertical, horizontal, multi-horizontal, and fishbone lateral wells, for all reservoir production layers. Artificial neural network tool was used to identify the optimal locations for obtaining the highest production from the reservoir layers and the optimal well type. Fo</p> ... Show More
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Publication Date
Tue May 01 2018
Journal Name
Applied Surface Science
Structural, morphological, and optical characterizations of Mo, CrN and Mo:CrN sputtered coatings for potential solar selective applications
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Publication Date
Wed Aug 31 2022
Journal Name
Iraqi Journal Of Science
Mineralogy of Sand Dune Fields around Hor Al-Dalmaj Between Wasit and Al-Qadesiyah Governorates - Central Iraq
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Vast percentage of the Hor Al-Dalmaj area is covered with sand dunes fields due to desertification. Therefore, it is vital to research these dunes to limit their bad action on the natural environment by defining the mineralogical composition of these sand dunes deposited around Hor Al-Dalmaj lake between Wast and Al-Qasisiyah Governorates to determine the provenance or the source of these dunes. Barchan and Nabkha dunes represent the main types that are recognized. The dimensions of barchan dunes are recognizing by a height range of about 0.5 to 3m, with lateral extension ranging from 2 to 15m and longitudinal extinction ranging from 3 to 15m. While the dimensions of nabkha dunes range from 10 cm to 2m in length and 15cm to 2m high. Acco

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