Objective: The goal of this research is to load Doxorubicin (DOX) on silver nanoparticles coupled with folic acid and test their anticancer properties against breast cancer. Methods: Chitosan-Capped silver nanoparticles (CS-AgNPs) were manufactured and loaded with folic acid as well as an anticancer drug, Doxorubicin, to form CS-AgNPs-DOX-FA conjugate. AFM, FTIR, and SEM techniques were used to characterize the samples. The produced multifunctional nano-formulation served as an intrinsic drug delivery system, allowing for effective loading and targeting of chemotherapeutics on the Breast cancer (AMJ 13) cell line. Flowcytometry was used to assess therapy efficacy by measuring apoptotic induction. Results: DOX and CS-AgNPs-DOX-FA were found to inhibit cell proliferation in the AMJ13 cell line, according to the findings. The anti-proliferative impact of these chemicals was attributed to cell death and activation of apoptosis, as evidenced by dual staining with acridine orange and Ethidium bromide. The presence of high fluorescent signals specific for cellular uptakes of CS-AgNPs-DOX-FA into the cell line's cytoplasm was confirmed. Conclusion: According to the findings of this study, CS-AgNPs-DOX-FA has a lot of promise to be used as an anticancer delivery system. The findings imply that this conjugate should be researched further for potential use as anticancer drug.
The alternating direction implicit method (ADI) is a common classical numerical method that was first introduced to solve the heat equation in two or more spatial dimensions and can also be used to solve parabolic and elliptic partial differential equations as well. In this paper, We introduce an improvement to the alternating direction implicit (ADI) method to get an equivalent scheme to Crank-Nicolson differences scheme in two dimensions with the main feature of ADI method. The new scheme can be solved by similar ADI algorithm with some modifications. A numerical example was provided to support the theoretical results in the research.
This paper is employed to discuss the effects of the magnetic field and heat transfer on the peristaltic flow of Rabinowitsch fluid through a porous medium in the cilia channel. The governing equations (mass, motion, and energy) are formulated and then the assumptions of long wavelength and low Reynold number are used for simplification. The velocity field, pressure gradient, temperature, and streamlines are obtained when the perturbation technique is applied to solve the nonlinear partial differential equations. The study shows that the velocity is decreased with increasing Hartmann number while it is decreased with increasing the porosity.
Density functional theory calculations are employed to investigate the impact of edifenphos molecule on the reactivity and electronic sensitivity of pure calcium oxide (CaO) nanocluster. The strong adsorption of edifenphos molecule on CaO nanocluster occurs by the sulfur head of the adsorbate, and the amount of the energy of this adsorption is around − 84.40 kcal/mol. The adsorption of edifenphos molecules results in a decrease in the values of Eg of CaO from 4.67 to 3.56 eV, as well as an increase in the electrical conductance. Moreover, the work function of CaO nanocluster is significantly affected, which changes the current of the field emission electron. Eventually, the recovery time is calculated around 99 ms at ambient temperature f
... Show MoreA nonlinear filter for smoothing color and gray images
corrupted by Gaussian noise is presented in this paper. The proposed
filter designed to reduce the noise in the R,G, and B bands of the
color images and preserving the edges. This filter applied in order to
prepare images for further processing such as edge detection and
image segmentation.
The results of computer simulations show that the proposed
filter gave satisfactory results when compared with the results of
conventional filters such as Gaussian low pass filter and median filter
by using Cross Correlation Coefficient (ccc) criteria.
Social media and networks rely heavily on images. Those images should be distributed in a private manner. Image encryption is therefore one of the most crucial components of cyber security. In the present study, an effective image encryption technique is developed that combines the Rabbit Algorithm, a simple algorithm, with the Attractor of Aizawa, a chaotic map. The lightweight encryption algorithm (Rabbit Algorithm), which is a 3D dynamic system, is made more secure by the Attractor of Aizawa. The process separates color images into blocks by first dividing them into bands of red, green, and blue (RGB). The presented approach generates multiple keys, or sequences, based on the initial parameters and conditions, which are
... Show MoreThe science of information security has become a concern of many researchers, whose efforts are trying to come up with solutions and technologies that ensure the transfer of information in a more secure manner through the network, especially the Internet, without any penetration of that information, given the risk of digital data being sent between the two parties through an insecure channel. This paper includes two data protection techniques. The first technique is cryptography by using Menezes Vanstone elliptic curve ciphering system, which depends on public key technologies. Then, the encoded data is randomly included in the frame, depending on the seed used. The experimental results, using a PSNR within avera
... Show MoreIn the current worldwide health crisis produced by coronavirus disease (COVID-19), researchers and medical specialists began looking for new ways to tackle the epidemic. According to recent studies, Machine Learning (ML) has been effectively deployed in the health sector. Medical imaging sources (radiography and computed tomography) have aided in the development of artificial intelligence(AI) strategies to tackle the coronavirus outbreak. As a result, a classical machine learning approach for coronavirus detection from Computerized Tomography (CT) images was developed. In this study, the convolutional neural network (CNN) model for feature extraction and support vector machine (SVM) for the classification of axial
... Show MoreIn this work, The effect of annealing treatment at different temperatures (373, 423 and 473) K and chemical treatment with talwen at different immersion time (40, 60 and 80) min on structural and optical properties of the bulk heterojunction (BHJ) blend copper phthalocyanine tetrasulfonic acid tetrasodium salt/poly dioxyethylenethienylene doped with polystyrenesulphonic acid (CuPcTs/PEDOT:PSS) thin films were investigated. The films were fabricated using spin coating technique. X-ray diffraction (XRD) measurements displayed only one peak at 2θ =4.5o corresponding to (001) direction which has dhkl larger than for standard CuPcTs. The dhkl increase then decrease with increasing annealing temperature and
the time of chemical treatment w
Background: One common undesirable side effect of orthodontic treatment with fixed appliances is the development of incipient caries lesions around brackets, particularly in patients with poor oral hygiene. Different methods have been used to prevent demineralization; the recent effort to improve the resistance against the demineralization is by the application of lasers. Materials and method: Thirty human premolars extracted for orthodontic purposes were used to test the effect of two energy level of ER-YAG laser on enamel resistance to demineralization. The brackets were bonded on the teeth and all the labial surface excluding 2 mm area gingival to the brackets were painted with acid resistance varnish. Three groups were generated. The fi
... Show MoreThis study investigates the impact of nonsurgical periodontal treatment (NSPT) on oral health-related quality of life (OHRQoL) in patients with periodontitis stages (S)2 and S3, and the factors associated with the prediction of patient-reported outcomes. Periodontitis patients (n = 68) with moderately deep periodontal pockets were recruited. Responses to the Oral Health Impact Profile (OHIP)-14 questionnaire and clinical parameters including plaque index, bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment loss (CAL) were recorded. All patients received supra- and subgingival professional mechanical plaque removal. All clinical parameters and questionnaire responses were recorded again 3 months after NSPT.
... Show More