Wellbore instability is one of the most common issues encountered during drilling operations. This problem becomes enormous when drilling deep wells that are passing through many different formations. The purpose of this study is to evaluate wellbore failure criteria by constructing a one-dimensional mechanical earth model (1D-MEM) that will help to predict a safe mud-weight window for deep wells. An integrated log measurement has been used to compute MEM components for nine formations along the studied well. Repeated formation pressure and laboratory core testing are used to validate the calculated results. The prediction of mud weight along the nine studied formations shows that for Ahmadi, Nahr Umr, Shuaiba, and Zubair formations ranges between 12.5 to 15 ppg. The predicted safe mud weight value seems to be narrow with a well deviation higher than 350. Therefore, for Ahmadi, Nahr Umr, Shuaiba, and Zubair formations, the wellbore appears unstable compared to other formations. The results of stability analyses indicate that the breakout mud weight wasn’t affected by wellbore azimuth because of low-stress contrast. Furthermore, shear failure can be prevented by drilling the well with an inclination of less than 350. As well as, to prevent breakdown the well should be drilled with an inclination between 25o to 65o in the direction of minimum horizontal stress. These outcomes could be used to prevent wellbore instability and determine a safe mud-weight window when planning to drill nearby wells in the future.