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Background: The synthesis and characterization of novel liquid crystalline compounds have garnered
signi|cant attention due to their potential applications in biomedical sciences, including drug delivery systems,
biosensing, and diagnostic tools. This study focuses on synthesizing and characterizing new
thiazolothiadiazole-based liquid crystals and evaluating their mesophase properties. Methods: A series of
novel compounds containing 5H-thiazolo[4,3−b][1,3,4] thiadiazole units were synthesized via multi-step
chemical reactions. The synthesis involved the reaction of chloroethyl acetate with 4−hydroxybenzaldehyde to
yield an aldehyde intermediate, followed by subsequent transformations using hydrazine hydrate, ethylacetoacetate, and 1,2
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