Osteoporosis (OP) is asymptomatic disease until the experience of falls or impacts that cause broken bones or fractures happened. Estrogen deficiency, abnormality in bone matrix components and interleukins expression can impact on bone homeostasis which gradually paved to osteoclastogenesis over activation leading to bone loss. A current case-control study was designed to explain the alteration in certain biochemicals, bone matrix components, immunological and molecular parameters that which accompanied with OP in the postmenopausal women. The period of study's investigation was from December 2022 to July 2023. All participants provided written informed consent, and the study was approved by Department of Biology, College of Science, University of Baghdad Ethical Council (Reference code CSEC/0922/0092, on 26-9-2022). One hundred and ten postmenopausal women were randomly chosen to participate in this study based on specific criteria from Al-Wasity Hospital, Medical City and Al- Imamein Kadhimein Medical City Hospitles, Baghdad, Iraq. The age of the participants was ranged from 45 to 70 years. Firstly, Dual Energy X-ray Absorptiometry (DEXA) scan was performed to all participants in order to assess the precence or abscense of OP disease. Out of 110 samples, 70 samples were confirmed with OP. Meanwhile, 40 samples were control. Venous blood samples were collected from all participants to estimated compelet blood count (CBC), immunological parameters as C-Reactive Protein (CRP), Rheumatoid Facter (RF), Anticyclical Citrullinated Peptide Antibody (ACPA), Interleukin-8 (IL8), Interleukin (IL-17), and Interleukins-22 (IL-22) using enzyme link immunosorbent assay (ELISA) technique, Parathyroid Hormone (PTH), and Calicum (Ca+2), bone matrix component parameters osteopontin (OPN), osteocalicn (OCN), and osteonectin (ON), in addition to,Osteopontin gene SNP rs11730582 polymorphism was determined by the Hight Resolution Melting (HRM) analysis. Highly significant (P≤0.01) decrease in WBC count (6.30±0.18 k/mcL) and HGB (9.900±0.132 g/dL) were observed in OP patients as when compared with the control group, WBC was (8.26±0.27k/mcL) and HGB was (13.321±0.287 g/dL), Conversely, highly significant (P≤0.01) increase was recorded in ESR (43.73±1.76 mm/hr), PLT (437.88±7.00 1083/uL) in OP patients in compare with control, (21.10±1.25mm/hr), and (226.79±9.39 1083/uL), respectively. However, highly significant (P≤0.01) increase was noticed in immunological parameters: CRP was (18.26±1.33 pg/ml), RF (IU/ml) results were positive, and ACPA was (23.26±2.74EU/ml) in OP patients when compared with control, CRP (2.92±0.18 pg/ml), RF (IU/ml) results were negative, and ACPA was (6.26±0.56 EU/ml). Beside to, highly significant (P≤0.01) increase was recorded in IL-8 serum level (249.08 ±19.98ng/ml), IL-17 (107.862±9.25ng/ml), and IL-22 (57.73±2.47 ng/ml) in OP patients as compared with the healthy control group were IL-8 (65.29 ± 5.62 ng/ml), IL-17 (46.135 ± 8.66 ng/ml) and IL-22 (13.57 ± 3.16 ng/ml). The mean PTH serum level of OP patients group was (77.80±1.79pg/mL) and in control group was (35.81±2.06pg/mL), whereas a highly significant (P≤0.01) decrease in mean of Ca⁺² serum level was recorded in OP patients (4.89±0.21 mmol/L) in compared with control group (9.63±0.13 mmol/L). Additionally, high significant (P≤0.01) increase was detected in OPN serum level (16.88±0.77 ng/ml) and OCN (29.86±2.25ng/ml) in OP patients as compared with the healthy control group (5.95±0.41ng/ml and 10.73±0.86ng/ml), respectively. In contrast, ON serum level recorded a highly significant (P≤0.01) decrease in the patient group (1.78±0.971ng/ml) compared with the control group (3.42±0.20ng/ml). The frequency of homozygote TT genotype in patient's analysis was, (14.3%), (10/70) than control group (27.5%), (11/40). While, the frequency heterozygote TC and homozygote mutant CC genotypes were [TC= (71.42%) 50/70 and CC= 14.3% (10/70)] and these genotypes frequency were not significantly differet from those of the control group, (TC= 60%, (24/40), and (CC= 12.5% 5/40). P-value was different (0.0158) significantly in genotype distribution of rs11730582 polymorphism in OP patients whereas, the P-value of rs11730582 was (0.1500) non-significant in control group. In conclusion, this study found that OPN, OCN, and ON protein act as a sensitive monitoring indicator can be used in early detection of osteoporosis. And because of the capacity to activate osteoclastogenesis and promote bone resorption, IL-8, IL-17, IL-22 and rs11730582 of OPN gene polymorphism may be serve as a biomarkers, pro-inflammatory and immune-stimulating factors in OP development.
Proteus mirabilis isolates have been intensively researched for their capacity to cause urinary tract infections (UTIs) and their swarming motility, although little is known about this phenomenon. Probiotic Lactobacillus species, which are beneficial bacteria, are being studied worldwide as therapeutic and preventative agents against bacterial infections. This study investigated Lactobacillus supernatants as a potential new treatment against Proteus mirabilis. In addition to testing their antimicrobial and anti-swarming activities, the research also aimed to understand the genetic mechanisms behind the observed phenotypic changes. Methods. A total of 150 urine specimens were collected from UTI patients at various hospitals in Baghdad. Dire
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Background: The altered status of some essential trace elements observed in diabetes could have deleterious influences on the health of the diabetics. Objectives: To estimate and study the potential role of serum Selenium in type 1, type 2 diabetics and healthy subjects; and its relation with lipid profile and glycemic index. Methods: A case control designed study was carried out at the National Diabetes Center (NDC) / Al-Mustansiria University; on a total of 94 participants formed of 32 type 1 diabetics, 32 type 2 diabetics and 30 healthy control participants. Data collected about age, sex and BMI; also, blood samples examined for FPG, HbA1C, serum total cholesterol, HDL cholesterol, non-HDL cholesterol, serum triglyceride and sera were
... Show MoreThis study is concerned look at the role of satellite channels in the dissemination of
consumer culture that has become part of our everyday lives , which is a dangerous
phenomenon on society , so the study is aimed at introducing the concept of consumer culture
and the risks to individuals , which conducted a field study on a sample of students from the
University of Baghdad, as they represent an important category of the society they are a class
of young people to get to know the impact of satellite television on them through their various
programs and serials, films and ads may develop consumer culture they have , including in
respect of ideas and information , where the questionnaire was developed to ensure diffe
The concept of civil society is one of the relatively recent concepts that have emerged clearly on the political and social arena especially in European countries, where it effectively contributes to the process of democratic transformation through the multiple roles and functions that it exercises, and acts as mediator between the state and the individual. Civil society in essence works to bring about change in society whether it is political, economic, social or cultural .The civil society appeared in Iraq after 2003, as is the case with many concepts that entered Iraq and took upon themselves the building of a democratic Iraq .Accordingly civil society institutions are the entity capable of rebuilding the Iraqi personal
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This study aims to study the inherited occupations which are considered to be a cultural, civilized and social legacy that effected by the Prevailing social and economic circumstances in the Iraqi society .
The study aimed to achieve several goals, including:
Identify the relationship between the urbanization and inherited occupations in the old city Al-Karkh.
Identify the relationship between the ecological construction and inherited occupations in the old city Al-Karkh.
Recognize the factors and motives inherited occupations in the study area .Identify the role of inherited occupations in promoting opportunities cohesion of the family system in the study area.
The field of the study had concentrated on a sample of famili
The research aims to demonstrate the role of organizational justice as an independent variable in influencing the achievement of development of the sense of psychological ownership of workers as a dependent variable. The current research variables were distinguished as being effective variables in terms of the field and affecting the achievement of success for organizations. In order to achieve this goal, it was applied on a sample of employees in the Iraqi Ministry of Transport employees, whose number reached (84) individuals, and the data were collected through the questionnaire as a main tool, to come out with a set of conclusions that contribute to raising the levels of the researched company, and based on the importance of the
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Background: Ulcerative colitis is a chronic inflammatory condition characterized by relapsing and remitting episodes of inflammation limited to the mucosal layer of the colon.Loop ileostomy might be helpful in the management of the disease.
Objective: To evaluate the role of loop ileostomy in the management of ulcerative colitis.
Methods: Between Januarys 2008 and January 2018, patients with fulminant ulcerative colitis resistant to medical therapy had been referred to our surgical unit and were included in our study. Assessment of the patients’ medical status (serum electrolytes, total serum protein, complete blood count, erythrocyte sedimentation rate, general stool exam,and abdominal ultrasound
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The concept of environmental debt, which has several dimensions, emerged in the nineties. One of these dimensions is spatial, referring to the debts that southern countries sustain due to the extraction of natural resources and environmental damage inflicted upon northern countries. Another dimension, the temporal dimension, concerns the environmental debts that current generations owe to their predecessors. That means past generations are culpable for overuse of natural resources and mismanagement. The debt issue is complex, despite many mechanisms to resolve it. Most important are the recently introduced environmental bonds, an important step forward in the field of sustainable financing of environmental debts.
The transition of professionals between different sectors is considered as one of sources of
acquisition of technology and will lead to add the practical experience to them. This experience
depending on different factors like: the scientific degree and practical experience by the
professionals, the technology possessed by the transferor sector, the duration that spent by
experienced in transferor sector, the type of work performed by professional….etc.
The research aims to verify the affect of these factors in technology transfer process.
Research reached that the technology transfer process which is depending on the Iraqi competencies
in work is unsatisfied level between Iraqi organizations because there are dif