One of the most important human diseases that need to be considered in terms of development of the medical engineering devices is cardiovascular disease which is a significant cause of death globally recently. Valvular heart disease is normally treated by restoring or altering heart valves with an artificial one. But the new prosthetic valve designs necessitate testing for durability estimate and failure method. It is significant to simulate the circulation system by the building of a pulse duplicator system. This study is stated by clarifying the parameter and implementation steps of the pulse duplicator system in which the different researchers have utilized the system and tried to explain the design steps of using this system without going into the system design by steps or what are the main part of this system and how can be implemented, tested, and developed individually. In this design, a DC motor produces, through a hydraulic piston, a flow pulse to the left ventricle chamber model, which is linked with two interchangeable prosthetic heart valves. The computer is used to control and process data from volumetric flow rate and image. The findings show that the linear displacement, the velocity of the piston and the linear acceleration regularly become significant particularly and follows a sinusoidal wave shape during one cycle, when (crank length/connecting rod length) value is equal 0.2 or less. Several sets of measured flow rate readings were obtained by using flow meter sensor YF-S201, results after calibration showed the error rate falls within permissible limits
