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The Correlation of P53 and MSI Immune Markers in Gastric Adenocarcinoma
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العلاقة بين تعبير المعلمات المناعية ل (P53) وعدم استقرار الساتل الميكروي  (MSI) مع العوامل السريرية المرضية لسرطان المعدة الغدي باستخدام الكيمياء النسيجية المناعية. الخلاصة الخلفية: يحدث سرطان المعدة الغدي بسبب عدم استقرار الكروموسومات، وطفرات TP53، واختلال الصيغة الصبغية، والانتقالات، والجينات الورمية الأولية، والتغيرات الجينية المثبطة للورم.عدم استقرار الساتل الميكروي(MSI)  يسبب فشل إصلاح عدم تطابق الحمض النووي، مما يؤثر على دقة تكرار الحمض النووي. يم الكشف عن أخطاء النسخ المتماثل المبكرة بواسطة مجمع البروتين المتغاير  (hMSH2/hMSH6) ، الذي يقوم بتفعيل hMLH1) و(hPMS2  لإعادة تكوين الحمض النووي. يحدث عدم استقرار الساتل الميكروي في حالات سرطان المعدة المتفرق ومتلازمة لينش. الهدف من الدراسة: دراسة العلاقة بين تعبيرالمعلم P53 وتعبير المعلمات المناعية لـعدم استقرار الساتل الميكروي (MSI) مع العوامل السريرية المرضية لسرطان المعدة الغدي باستخدام الكيمياء النسيجية المناعية. المواد والطرق: تم فحص 40 كتلة من نسيج سرطان المعدة الغدي المثبت بالفورمالين والمطمور بالشمع في بغداد، العراق. تناولت الدراسة حالات سرطان المعدة الأولية، مع البيانات السريرية المرضية المتاحة، والأنسجة الجراحية. التعبير المناعي الكيميائي الذي تم تقييمه بواسطة نظام تسجيل النقاط. تم استخدام برنامج SPSS لتحليل البيانات، كما تم استخدام اختبارات Chi-square واختبارات Fisher الدقيقة لتقييم الارتباطات. تم اعتبار مستوى الثقة 95٪ والقيمة الاحتمالية P 0.05 أو أقل مهمًا. النتائج : كان التصبيغ المناعي النسيجي الكيميائي لـ P53 إيجابيًا في 65٪ من الحالات، بينما كانت نتائج MSI إيجابية في 97.5٪ من الحالات. حصل الزوجان المتغايران MLH1/PMS2 على نتائج إيجابية بنسبة 32.5% ونتائج سلبية 67.5%، في حين حصل الزوجان المتغايران MSH2/MSH6 على نتائج إيجابية بنسبة 87.5% ونتائج سلبية 12.5%. ارتبطت صبغة P53 بشكل كبير بانتشار العقدة الليمفاوية  ودرجة الورم ، ولكن لم يكن هنالك ارتباط مع العوامل الأخرى. لم يتم العثور على ارتباط كبير بين معلمات MSI والعوامل المدروسة,لم يكن هناك ارتباط كبير بين معلمات MSI غير المتجانسة (MLH1 / PMS2) والمعلمات المرضية السريرية، ولكن كان هناك ارتباط كبير بين علامات MSI الزوجين غير المتجانسة (MSH2 / MSH6) والنقائل فقط . الاستنتاج: : يعد P53 معلما حيويا مهما لتقييم انتشار العقدة الليمفاوية  وعدوانيتها في التصنيف النسيجي، مما يشير إلى التشخيص، وتحديد مرضى السرطان الأكثر عرضة لخطر الإصابة بالورم النقيلي. على الرغم من أن MSH2/MSH6  اظهر ارتباطا مهمًا مع النقائل الورمية ، إلا أن معلمات MSI كان لها أقل قيمة إنذارية في دراستنا. هناك حاجة إلى مزيد من البحث لإثبات فعاليتها في علاج سرطان المعدة.

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Publication Date
Thu Jan 01 2026
Journal Name
Opción: Revista De Ciencias Humanas Y Sociales, Issn 1012-1587, Nº. 89, 2019
The effectiveness of employing the molecular representation strategy in the development of information Generation skills in the chemistry of second grade students in Intermediate School
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Autoría: Jehan Faris Yousif. Localización: Opción: Revista de Ciencias Humanas y Sociales. Nº. 89, 2019. Artículo de Revista en Dialnet.

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Scopus
Publication Date
Wed Jan 03 2024
Journal Name
Eximia
The reality of the organizational brilliance of physical Educators in the college of Physical Education and Sports Sciences / University of Baghdad from female students point of view
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Achieving goals effectively reflects the success of the institution. However, unless this indicator is coupled with efficiency when achieving goals, the institution will be equal in its achievements, and distinction will remain unachieved. Perhaps the role of the teaching staff in pushing the institution or college towards brilliance focuses on their ability to motivate people on the one hand and their interest in achieving brilliance for the institution. On the other hand, the importance of the research lies in the institution’s reaching a prominent position through the brilliance and creativity of teaching and achieving competition between institutions that make it more brilliance. The study seeks to achieve the goal of the real

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Crossref
Publication Date
Wed Nov 03 2021
Journal Name
Al-ghary Journal Of Economic And Administrative Sciences
The Role of Marketing Vigilance in Analyzing the Strategic Position of Tourism Organization: A Survey Study of the Opinions of a Sample of Travel and Tourism Companies
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The study aims at studying and analyzing the subject of marketing vigilance as it is one of the modern approaches in the marketing field that can be used to face changes in the competitive and strategic environment and that represents quick reactions on the part of the institution to ensure its survival and distinctiveness other aims are: Consolidating the strength of the marketing organization and its success continuously, represented by changes in the market share, awareness of the institution's position in the market and its relations with competing tourism companies, diversification of tourism services, as well as an analysis of the competitive strategic position of tourism institutions for the purpose of conducting a r

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Crossref
Publication Date
Fri Feb 01 2019
Journal Name
Journal Of Economics And Administrative Sciences
"The relationship between the profits management and profits quality and their impact on users of accounting information (A comparative study of a sample of banks listed in the Iraqi market for securities)
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The aim of the research is to determine the impact of profit management practices on the quality of profits through the use of flexibility in determining accounting methods and practices profit information is one of the most important information that concerns current users in general and observing users in particular. Some corporations managements manipulate the results of the company's profit or loss (income statement) and financial position statement with multiple reasons, including capital market motivations to raise their share prices in the stock market and attract investors, and on the other hand the motives of funding and borrowing loans, and the use of the flexibility in accounting policies and estimates to change the in

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Crossref
Publication Date
Sun Dec 01 2019
Journal Name
Journal Of Economics And Administrative Sciences
The extent of the contribution of the determinants of organizational support in the enhancement of the mental status of banking services - A study of the views of a sample of employees in a number of banks in the city of Dohuk
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     The objective of this study is to determine the extent to which the determinants of organizational support contributed to enhancing the mental status of banking services in a number of banks in Dohuk governorate in order to diagnose the correlation between the perceived organizational support and the mental status of services. Availability in the environment of banks and to enhance the mental position from the point of view of customers as the main hypotheses focused on the nature of the relationship between the dimensions of research among them has been tested these hypotheses using statistical and descriptive methods have been The study concluded that the contribution of organizational support, which is

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Crossref
Publication Date
Sun Feb 10 2019
Journal Name
Journal Of The College Of Education For Women
Land Uses temporary agricultural in the province of Maysan and its relationship to soil salinity and its chemical
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The research aims to learn spatial disparities tracts of agricultural crops in the
province of Maysan and their relationship (the salinity of the soil and the degree of chemical
interaction (PH)) The research is divided into an introduction and three Investigation eat first
section spatial disparities agricultural crops (cereals, vegetables, legumes and forage). The
comparison between the years of production in the province where the province has seen
varied spatial by hand and taking second section degrees of soil salinity and its impact on
agriculture, as well as the chemical reaction (PH) and its impact on agriculture The third
section has been used three technical techniques first linkage and the second simple an

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Publication Date
Fri Feb 01 2019
Journal Name
Journal Of Economics And Administrative Sciences
Adopting IPSASs and its impact on the quality of financial reporting and performance evaluation in Iraqi government units
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Abstract

     Performance evaluation is of great importance in all countries of the world, because it has a prominent and effective role in determining the efficiency and effectiveness of the optimal use of available resources, which are rare and important in achieving the desired objectives. With the continued growth of public spending and the limited resources, the State seeks to achieve its objectives through its units with minimal expenditure or deficit, rationality and wastefulness in the spending. In many countries, particularly developing countries, reforms are made in the public sector to achieve that goal through the adoption of IPSAS, which is reflected in the developmen

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Crossref
Publication Date
Tue Jan 01 2002
Journal Name
Msc Thesis
Anatomical , Histological and Ultrastructural Study of the Hypophysis and Epiphysis Cerebri in Common Quail . Coturnix coturnix coturnix L
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Publication Date
Tue Aug 15 2023
Journal Name
Al-academy
Trends in Contemporary Ceramic Art and the Overlapping of Stylistic Concepts (Installation Art and Assemblage as a Model)
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Contemporary arts have achieved, in accordance with the transition of concepts, a new logic in presentation and expression in general, and specifically in the field of ceramic art. The shift towards the logic of rejection and subversion of prevailing methods, which have been almost a constant foundation for a long period, has directly influenced the direction of visual arts in the contemporary world.
The growth and cultural transformations that the world has witnessed after the two World Wars have produced cognitive shifts based on strategies that diverge from the dominant culture. These approaches vary according to existential needs, as the language of art has become conceptual and a medium for contemporary culture with its rapid an

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Crossref
Publication Date
Thu Mar 19 2015
Journal Name
Al-academy
Pleasure and Emotions and their role in aesthetics' experience of the user: صلاح نوري محمود، جاسم خزعل العقيلي
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Industrial product is one of the things of daily use and direct interaction with the user, so the ranges of its association to the user, took a varied and multiple aspects. The user today sees the products as things have specifications related directly to the psychology of the user, so he can reflects his values, principles and ideas on the composition of the total structure of the product, making them a means by which manifested the internal entity's of the user took an external materiality. And then counting the products being things excite positive feelings among different user was a natural result given the complexity of the relationship between the user and the industrial product. So pleasure is one important effects that result fro

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