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The Correlation of P53 and MSI Immune Markers in Gastric Adenocarcinoma
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العلاقة بين تعبير المعلمات المناعية ل (P53) وعدم استقرار الساتل الميكروي  (MSI) مع العوامل السريرية المرضية لسرطان المعدة الغدي باستخدام الكيمياء النسيجية المناعية. الخلاصة الخلفية: يحدث سرطان المعدة الغدي بسبب عدم استقرار الكروموسومات، وطفرات TP53، واختلال الصيغة الصبغية، والانتقالات، والجينات الورمية الأولية، والتغيرات الجينية المثبطة للورم.عدم استقرار الساتل الميكروي(MSI)  يسبب فشل إصلاح عدم تطابق الحمض النووي، مما يؤثر على دقة تكرار الحمض النووي. يم الكشف عن أخطاء النسخ المتماثل المبكرة بواسطة مجمع البروتين المتغاير  (hMSH2/hMSH6) ، الذي يقوم بتفعيل hMLH1) و(hPMS2  لإعادة تكوين الحمض النووي. يحدث عدم استقرار الساتل الميكروي في حالات سرطان المعدة المتفرق ومتلازمة لينش. الهدف من الدراسة: دراسة العلاقة بين تعبيرالمعلم P53 وتعبير المعلمات المناعية لـعدم استقرار الساتل الميكروي (MSI) مع العوامل السريرية المرضية لسرطان المعدة الغدي باستخدام الكيمياء النسيجية المناعية. المواد والطرق: تم فحص 40 كتلة من نسيج سرطان المعدة الغدي المثبت بالفورمالين والمطمور بالشمع في بغداد، العراق. تناولت الدراسة حالات سرطان المعدة الأولية، مع البيانات السريرية المرضية المتاحة، والأنسجة الجراحية. التعبير المناعي الكيميائي الذي تم تقييمه بواسطة نظام تسجيل النقاط. تم استخدام برنامج SPSS لتحليل البيانات، كما تم استخدام اختبارات Chi-square واختبارات Fisher الدقيقة لتقييم الارتباطات. تم اعتبار مستوى الثقة 95٪ والقيمة الاحتمالية P 0.05 أو أقل مهمًا. النتائج : كان التصبيغ المناعي النسيجي الكيميائي لـ P53 إيجابيًا في 65٪ من الحالات، بينما كانت نتائج MSI إيجابية في 97.5٪ من الحالات. حصل الزوجان المتغايران MLH1/PMS2 على نتائج إيجابية بنسبة 32.5% ونتائج سلبية 67.5%، في حين حصل الزوجان المتغايران MSH2/MSH6 على نتائج إيجابية بنسبة 87.5% ونتائج سلبية 12.5%. ارتبطت صبغة P53 بشكل كبير بانتشار العقدة الليمفاوية  ودرجة الورم ، ولكن لم يكن هنالك ارتباط مع العوامل الأخرى. لم يتم العثور على ارتباط كبير بين معلمات MSI والعوامل المدروسة,لم يكن هناك ارتباط كبير بين معلمات MSI غير المتجانسة (MLH1 / PMS2) والمعلمات المرضية السريرية، ولكن كان هناك ارتباط كبير بين علامات MSI الزوجين غير المتجانسة (MSH2 / MSH6) والنقائل فقط . الاستنتاج: : يعد P53 معلما حيويا مهما لتقييم انتشار العقدة الليمفاوية  وعدوانيتها في التصنيف النسيجي، مما يشير إلى التشخيص، وتحديد مرضى السرطان الأكثر عرضة لخطر الإصابة بالورم النقيلي. على الرغم من أن MSH2/MSH6  اظهر ارتباطا مهمًا مع النقائل الورمية ، إلا أن معلمات MSI كان لها أقل قيمة إنذارية في دراستنا. هناك حاجة إلى مزيد من البحث لإثبات فعاليتها في علاج سرطان المعدة.

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Publication Date
Wed Aug 17 2022
Journal Name
Al–bahith Al–a'alami
Visual Perception and Persuasion in Television Advertising An analytical study
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The picture has taken a place that sometimes enables it to take precedence over media analysis، psychology، and political communication.
The image has the ability to influence to obtain persuasion، not only emotionally or
dramatically، but also on the level of commercial and political persuasion. In every
image، the intention of that persuasion is hidden.
It can be identified by a set of underlying dimensions such as vitality، social dominance، and confidence، for which a group of specific suggestions or movements، such
as a smile، the movement of hands، or the nature and way of looking with the eyes، is
established. The visual image often precedes its verbal counterpart in the proce

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Publication Date
Sun Jun 20 2021
Journal Name
Baghdad Science Journal
Hypothyroidism and Leptin in Iraqi Patients with Chronic Kidney Disease
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The present study aims at assessing the effects of chronic kidney disease (CKD) on thyroid hormone and leptin by evaluating the level of: leptin hormone along with thyroid hormone in CKD patients. The study has been conducted on  70 subjects, 50 patients with an age range between 20-50 years (25  males and 25 females) who were diagnosed to have CKD stage-5, and 20 normal controls whose ages ranged between 20-48 years (10  males and 10 females), who attended  the Nephrology and Transplant Center in Medical City of Baghdad- Iraq from April  2018  to July  2018. The study showed a highly significant (P<0.01) increase in TSH level in CKD patients in comparison with controls. While T3 and T4 levels observed highly significant decrea

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Publication Date
Mon Aug 21 2017
Journal Name
Biomedical And Pharmacology Journal
Gene Expression and Clinical Manifestations in Iraqi Patients with Acromegaly
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Publication Date
Tue Dec 01 2020
Journal Name
Journal Of Economics And Administrative Sciences
Strategic Entrepreneur ship and its role in a marketing performance
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The current research aims through its chapters to verify the relationship and impact of strategic leadership as an independent variable in the marketing performance as a respondent variable, in a leap cement plant, and try to come up with a set of recommendations that contribute to enhancing the practice and adoption of the two variables in the organization under discussion. And based on the importance of the research topic to the community, and to the researched organization and its members, the analytical and analytical approach was adopted in the completion of this research, and the research community included a leap cement plant in Anbar Governorate, while the research sample was represented by (department heads, and people o

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Publication Date
Fri Sep 01 2023
Journal Name
Civil Engineering Journal
Fundamental Challenges and Management Opportunities in Post Disaster Reconstruction Project
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The study examines the root causes of delays that the project manager is unable to resolve or how the decision-maker can identify the best opportunities to get over these obstacles by considering the project constraints defined as the project triangle (cost, time, and quality) in post-disaster reconstruction projects to review the real challenges to overcome these obstacles. The methodology relied on the exploratory description and qualitative data examined. 43 valid questionnaires were distributed to qualified experienced engineers. A list of 49 factors causes was collected from previous international and local studies. A Relative Important Index (RII) is adapted to determine the level of importance of each sub-criterion in the fou

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Publication Date
Wed Sep 30 2015
Journal Name
College Of Islamic Sciences
Some responses to ancient grammarians And contemporary researchers In monograms
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Some responses to ancient grammarians
And contemporary researchers
In monograms

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Publication Date
Sun Feb 10 2019
Journal Name
Journal Of The College Of Education For Women
Emotional Intelligence in kindergarten and its relationship with some variables
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This study aims at finding out the sentimental smartness of the kindergarten children
and its relationship with some variables.
1- The level of the sentimental smartness of the kindergarten children.
2- Investigating the Zero hypothesis in that there are no significant statistical differences in
the sentimental smartness between the kindergarten children according to the sex variables
(males and females).
Some statistical tools have been used in order to arrive at the results that verify the
hypotheses of this study. The researcher uses (1) the distinctive power between two
distinctive groups; (2) the relationship between the item and the total degree (Pearson
correlation factor); and (3) Elfakronbach formula t

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Publication Date
Thu May 18 2023
Journal Name
Journal Of Engineering
Experimental and Numerical Study on Cavitation Effects in Centrifugal Pumps
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Experimental and numerical investigations of the centrifugal pump performance at non-cavitating and cavitating flow conditions were carried out in the present study. Experiments were performed by applying a vacuum to a closed-loop system to investigate the effects of the net positive suction head available (NPSHa), flow rate, water temperature and pump speed on the centrifugal pump performance. Accordingly, many of the important parameters concerning cavitation phenomenon were calculated. Also, the noise which is accompanied by cavitation was measured. Numerical analysis was implemented for two phase flow (the water and its vapor) using a 2-D simulation by ANSYS FLUENT software to investigate the internal flow of centrifugal pump under c

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Publication Date
Wed Feb 01 2023
Journal Name
Practice Periodical On Structural Design And Construction
Best Practice Strategies for Workforce Development and Sustainability in Construction
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Publication Date
Fri Jul 14 2023
Journal Name
Aip Conference Proceedings
Seismic impact on makhool earthdam in flood and drought seasons
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