Background: The genetic polymorphisms of vitamin D receptor (VDR) have an association with thalassemia development, additionally to the environmental elements that elicited the disorder in the genetically predisposed individuals. As well, VDR functions responsible for the regulation of bone metabolism, such its part in immunity. Aim: The sitting study intended to inspect the association between thalassemia disease and the genetic polymorphisms of VDR among the Iraqi population then compared these findings to other findings of thalassemia patients in other different ethnic populations. Materials and methods: The restriction enzymes Bsm-I and Fok-I were applied to determine the genetic polymorphisms frequencies of VDR by a Polymerase Chain Reaction – Random Fragment Length Polymorphisms (PCR-RFLP) techniques of the targeted parts (rs2228570 and rs1544410) in 70 Iraqi patients suffering from thalassemia (18 males and 52 females) and 75 Iraqi healthy participants as a control group (18 males and 52 females). Also, the comparison between the present findings of VDR genetic polymorphisms in Iraqi thalassemia patients and other previous findings for thalassemia patients in different ethnic populations for the selected VDR Bsm-I and Fok-I sites were done. Results: The present findings manifested a significant difference of VDR Bsm-I and Fok-I genetic polymorphisms frequency (rs2228570 and rs1544410) in the thalassemia patient's group contrasted to the healthy control group. In VDR rs2228570, the AA genotype and A allele frequency were significantly increased in the patients' group contrasted to the healthy control group (44.29 vs. 8.0%, OR: 9.14, 95% CI: 3.53–23.68, p: 4.1 × 10−7; 69.0 vs. 27.0%, OR: 6.02, 95% CI: 3.27–11.06, p: 3.9 × 10−9, respectively). while, the results of VDR genetic polymorphisms rs1544410 manifested that the CC and CT genotyping and C allele frequency were significantly increased among the patient's group contrasted to the healthy control group (28.75 vs. 6.67%, OR: 5.60, 95% CI: 1.98–15.81, p: 7.2 × 10−4; 57.14 vs. 24.0, OR: 4.22, 95% CI: 2.08–8.55, p: 8.1 × 10−5; and 57.0 vs. 19.0%, OR: 6.39, 95% CI: 3.0–10.66, p: 3.9 × 10−9, respectively). Also, it manifested the genetic polymorphisms variance of VDR rs2228570 and rs1544410 between the Iraqi thalassemia patients and other ethnic thalassemia patients. The results showed different variants among the Iraqi thalassemia patients' polymorphisms and other ethnic thalassemia patients' polymorphisms. Conclusions: The present results demonstrated a significant association between the genetic polymorphisms of VDR and thalassemia disease, the AA genotype and A allele frequency was significantly increased among the thalassemia patients' group compared to the controls in VDR Bsm-I polymorphism (rs2228570). While the CC and CT genotypes and C allele frequency were significantly increased among the thalassemia patients' group compared to the controls in VDR Fok-I polymorphism (rs1544410). As well, it indicates the variance of VDR Bsm-I and Fok-I genetic polymorphisms frequencies between the Iraqi thalassemia patients and other thalassemia patients from different ethnic populations.
The present paper aims at finding out the Variance Ratio of Trips Set Out by Scholars of Both Marrouzzeen and Baihaq .The researcher has come up with conclusion including certain findings ,one of which is that the trip is considered an essential base with high effectiveness since the old times and has been evolved .This means that the trip has been the main source of knowledge and sciences from the scholars directly .This had driven the scholars of both Baihaq and Marrouz cities .It has been noticed , though this paper, that the number of the Marrouz scholars who visited was less than those of Baihaq . The researcher has focused on their meetings or conferences and investigated what has been going on in such meetin
... Show MoreThe geometric morphometric technique was used to study the variables in the shape and size wings of different populations of mosquitoes Culex quinquefasciatus from different Iraqi provinces Babylon, Baghdad and Wasit. The results showed that the average of centroid size were 366, 387.5 and 407.4 Micron in Babylon, Baghdad and Kut, respectively. The statistical analysis showed that there were no significant differences in the average of centroid size of all specimens and they belong to the same species.
In the current digitalized world, cloud computing becomes a feasible solution for the virtualization of cloud computing resources. Though cloud computing has many advantages to outsourcing an organization’s information, but the strong security is the main aspect of cloud computing. Identity authentication theft becomes a vital part of the protection of cloud computing data. In this process, the intruders violate the security protocols and perform attacks on the organizations or user’s data. The situation of cloud data disclosure leads to the cloud user feeling insecure while using the cloud platform. The different traditional cryptographic techniques are not able to stop such kinds of attacks. BB84 protocol is the first quantum cry
... Show MoreThis experiment was conducted to examine the effects of injected gibberellic acid GA3 in subcutaneous of hens neck and supplemental vitamin D3 to control basal diet on productive performance and egg shell thickness ,relative weight of egg shell of aged laying hens. Two hundred and seventy Lohmann Brown laying hens at 73 weeks of age were randomly assigned to three treatments groups. Each treatment consist of three replicates (30 hens / replicate). The treatments were : T1 control were injected subcutaneous with 0.2 ml / kg of body weight of ethanol: sesame oil solution, T2 and T3 were injected subcutaneous with 0.2 ml / kg of body weight of ethanol: sesame oil solution which contained 400 μg GA3/ kg of body weight /week during 8 weeks (tre
... Show MoreThe study addresses the problem of stagnation and declining economic growth rates in Arab countries since the eighties till today after the progress made by these countries in the sixties of the last century. The study reviews the e
... Show MoreThe researcher of human history finds that the first social relations on earth were represented by the violence of Adam, peace be upon him, Cain and Abel. Violence has been a phenomenon of life and society. The history of history is full of all forms of violence and its forms. It speaks of cruelty, oppression and states. History began, in some of its chapters, written with the blood of the victims. It is a testimony to the cruelty of human beings. His human nature and his sin have played a major role that can not be overlooked in the development of important and fundamental developments in some historical turning points where violence was a necessity for life, and its launching change, renewal and reform, and major revolutions in human h
... Show MoreIn this research, the focus was placed on estimating the parameters of the Hypoexponential distribution function using the maximum likelihood method and genetic algorithm. More than one standard, including MSE, has been adopted for comparison by Using the simulation method
In this research, optical communication coding systems are designed and constructed by utilizing Frequency Shift Code (FSC) technique. Calculations of the system quality represented by signal to noise ratio (S/N), Bit Error Rate (BER),and Power budget are done. In FSC system, the data of Nonreturn- to–zero (NRZ ) with bit rate at 190 kb/s was entered into FSC encoder circuit in transmitter unit. This data modulates the laser source HFCT-5205 with wavelength at 1310 nm by Intensity Modulation (IM) method, then this data is transferred through Single Mode (SM) optical fiber. The recovery of the NRZ is achieved using decoder circuit in receiver unit. The calculations of BER and S/N for FSC system a
... Show MoreObjective: The study aims at assessing the food frequency intake and dietary habits for diabetic pregnant
women.
Methodology: A descriptive study is carried out for the period from November4th 2013 to August
25th 2014. A purposive "non-probability" sample of one hundred diabetic pregnant women is selected from
the Diabetic and Endocrine Center in Al-Amarha City. A questionnaire is developed as a tool of data
collection. Content validity of the study instrument is determined through panel of experts. Split-half
reliability technique is used for reliability determination of the study instrument which depicts a reliability
coefficient of (0.79) for the entire scale. A structured interview with each diabetic pregnant wom
In this study, structures damage identification method based on changes in the dynamic characteristics
(frequencies) of the structure are examined, stiffness as well as mass matrices of the curved
(in and out-of-plane vibration) beam elements is formulated using Hamilton's principle. Each node
of both of them possesses seven degrees of freedom including the warping degree of freedom. The
curved beam element had been derived based on the Kang and Yoo’s thin-walled curved beam theory
in 1994. A computer program was developing to carry out free vibration analyses of the curved
beam as well as straight beam. Comparing with the frequencies for other researchers using the general
purpose program MATLAB. Fuzzy logic syste