Background: The genetic polymorphisms of vitamin D receptor (VDR) have an association with thalassemia development, additionally to the environmental elements that elicited the disorder in the genetically predisposed individuals. As well, VDR functions responsible for the regulation of bone metabolism, such its part in immunity. Aim: The sitting study intended to inspect the association between thalassemia disease and the genetic polymorphisms of VDR among the Iraqi population then compared these findings to other findings of thalassemia patients in other different ethnic populations. Materials and methods: The restriction enzymes Bsm-I and Fok-I were applied to determine the genetic polymorphisms frequencies of VDR by a Polymerase Chain Reaction – Random Fragment Length Polymorphisms (PCR-RFLP) techniques of the targeted parts (rs2228570 and rs1544410) in 70 Iraqi patients suffering from thalassemia (18 males and 52 females) and 75 Iraqi healthy participants as a control group (18 males and 52 females). Also, the comparison between the present findings of VDR genetic polymorphisms in Iraqi thalassemia patients and other previous findings for thalassemia patients in different ethnic populations for the selected VDR Bsm-I and Fok-I sites were done. Results: The present findings manifested a significant difference of VDR Bsm-I and Fok-I genetic polymorphisms frequency (rs2228570 and rs1544410) in the thalassemia patient's group contrasted to the healthy control group. In VDR rs2228570, the AA genotype and A allele frequency were significantly increased in the patients' group contrasted to the healthy control group (44.29 vs. 8.0%, OR: 9.14, 95% CI: 3.53–23.68, p: 4.1 × 10−7; 69.0 vs. 27.0%, OR: 6.02, 95% CI: 3.27–11.06, p: 3.9 × 10−9, respectively). while, the results of VDR genetic polymorphisms rs1544410 manifested that the CC and CT genotyping and C allele frequency were significantly increased among the patient's group contrasted to the healthy control group (28.75 vs. 6.67%, OR: 5.60, 95% CI: 1.98–15.81, p: 7.2 × 10−4; 57.14 vs. 24.0, OR: 4.22, 95% CI: 2.08–8.55, p: 8.1 × 10−5; and 57.0 vs. 19.0%, OR: 6.39, 95% CI: 3.0–10.66, p: 3.9 × 10−9, respectively). Also, it manifested the genetic polymorphisms variance of VDR rs2228570 and rs1544410 between the Iraqi thalassemia patients and other ethnic thalassemia patients. The results showed different variants among the Iraqi thalassemia patients' polymorphisms and other ethnic thalassemia patients' polymorphisms. Conclusions: The present results demonstrated a significant association between the genetic polymorphisms of VDR and thalassemia disease, the AA genotype and A allele frequency was significantly increased among the thalassemia patients' group compared to the controls in VDR Bsm-I polymorphism (rs2228570). While the CC and CT genotypes and C allele frequency were significantly increased among the thalassemia patients' group compared to the controls in VDR Fok-I polymorphism (rs1544410). As well, it indicates the variance of VDR Bsm-I and Fok-I genetic polymorphisms frequencies between the Iraqi thalassemia patients and other thalassemia patients from different ethnic populations.
Background: Drug resistant epilepsy is defined as failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug schedules to achieve sustained seizure freedom. Up to 30% of patients referred to clinics with a diagnosis of pharmaco-resistant epilepsy may have been misdiagnosed, and many can be helped by optimizing their treatment.Pseudoresistance, in which seizures persist because the underlying disorder has not been adequately or appropriately treated, must be ruled out or corrected before drug treatment can be considered to have failed.
Objectives: The objectives of this study were to determine the causes of drug failure in patients with epilepsy and to differenti
... Show MoreAbstract:
Objectives: This study aims to (1) find out the association between patients' age, years of getting the disease, and their spiritual coping ability, and (2) investigate the differences in illness perception and spiritual coping ability between gender groups, level of education groups, monthly income groups, residence groups and satisfaction with health services groups.
Methodology
A descriptive correlational design is used in this study. The study sample includes a convenience sample of (158) patients with chronic kidney failure.
The study instrument consists of two parts; the first one focuses on participants’ sociodemographic characteristics, and the second part deals with participants’ spiritual coping by us
Abstract A descriptive study to assess the quality of life (QOL) for patients with colorectal cancer. The study was conducted from Baghdad Teaching Hospital, Al-Yarmouk Teaching Hospital and Radiation Hospital and Nuclear medicine for the period from 1st July/2004 to 1st September/2004. The sample selected by purposive random of (50) patients diagnosed with colorectal cancer and all of them who were under chemotherapy treatment. A questionnaire was prepared for the purpose of the study and comprised of three parts including: 1- Socio-demographical characteristics. 2- Clinical characteristics. 3- and QOL
This research was conducted to measure the safety of heat stable enterotoxin a (STa) produced by enterotoxigenic Escherichia coli, through studying its toxic effect on human blood lymphocyte, since it showed a promising effect in reducing the proliferation of colorectal cancer cells. the cytogenetic effects of (STa) by using five different concentrations (100, 200, 400, 800 and 1600μg/ml) in comparison with negative (PBS, Phosphate buffer saline) and positive (MMC, Mitomycin C) at concentration of 5μg/ml, controls on human blood lymphocytes obtained from both (10) normal healthy persons and (20) colorectal cancer patients was measured by employing the following parameters: mitotic index, blast index, chromosomal aberrations and micronucle
... Show MoreEmergency contraceptives (ECs) are indicated for preventing the chance of unintended pregnancy that follows unprotected sexual intercourse in cases of incorrectly used regular contraceptives and in sexual assault. It is considered a safe choice to prevent pregnancy than abortion which is considered life threating. The aim of this study was to assess knowledge, attitude, and practices (KAP) of community pharmacists towards emergency contraceptives and their association with sociodemographic variables. This study was a cross sectional study conducted between August and September 2021 on a convenient sample of community pharmacists from Iraq. The survey tool was an online, self-administered questionnaire, in English language and a paper-bas
... Show MoreAt a time when the general rules in the different legal systems require the presence of two parties to the contract, one of which is issued the first expression of the will and is called the offer, and the other is issued from the other and is called the acceptance. A special type of contracts emerged in the beginning of the last century called the “unilateral contracts”. The side sparked a major jurisprudential dispute, as well as the issuance of several contradictory judicial rulings on it. Hence, this research came to highlight this special type of contract. Key words: the definition of a unilateral contract, its distinction from other legal situations, and its effects.
Everywhere carriers incur a measure of liability for the safety of the goods. Carriers are liable for any damage or for the loss of the goods that are in their possession as carriers unless they prove that the damage or loss is attributable to certain excepted causes. Damaged and lost items can unfortunately be a common problem when shipping freight. Legal responsibilities arise due to loss or damage during transit while cargo is in their care. This study intends to investigate the nature of the liability of the maritime carrier when this liability is realized, and the extent to which it can be paid or disposed of given the risks realized from the transportation process, which may result in damage or loss of the goods, and the damag
... Show MoreReconstruction in Iraq requires coherent legitimate frameworks that are able to detail obligations, rights and responsibilities of the parties participating in reconstruction projects, regardless their type or delivery system.
Conditions of Contract can be considered an important component of these frameworks. This paper investigates flexibility and appropriateness of the application of Iraqi conditions of contract in reconstruction projects. These conditions were compared to FIDIC Conditions. The objective wasn't comparing individual clauses, but rather exploring the principles and philosophy laying behind each conditions, and to what extent each conditions care about realizing equity between main contract parties. Validity of applic
Reseach target the most important topic, is Activity and ProfitabilityIndictors Analysis for
Nationality and Iraqi Insurance Company, In order to stand on them ability to cover its risks
and explore the efficiency asset and its avialible resources using to determine them abilities to
profit generation from its insurance activity. The analysis was focus to examine their profit
and activity power, and test the significant differences aming them performance. Test 2
hypothese that is related and result it sign that the 2 company no has significant differences at
profitability and activity level. The research depend on coneclusion, recommended two
company to work at efficiency with cost element of insurance activity in or