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Many patients with advanced type 2 diabetes mellitus (T2DM) and all patients with T1DM require insulin to keep blood glucose
levels in the target range. The most common route of insulin administration is subcutaneous insulin injections. There are many
ways to deliver insulin subcutaneously, such as vials and syringes, insulin pens, and insulin pumps. Though subcutaneous insulin
delivery is the standard route of insulin administration, it is associated with injection pain, needle phobia, lipodystrophy,
noncompliance, and peripheral hyperinsulinemia. Therefore, the need exists to deliver insulin in a minimally invasive or
noninvasive way and in the most physiological way. Inhaled insulin was the first approved noninvasive and alternative way
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