FLI1 is a member of ETS family of transcription factors that regulate a variety of normal biologic activities including cell proliferation, differentiation, and apoptosis. The expression of FLI1 and its correlation with well-known breast cancer prognostic markers (ER, PR and HER2) was determined in primary breast tumors as well as four breast cancer lines including: MCF-7, T47D, MDA-MB-231 and MDA-MB-468 using RT-qPCR with either 18S rRNA or ACTB (β-actin) for normalization of data. FLI1 mRNA level was decreased in the breast cancer cell lines under study compared to the normal breast tissue; however, Jurkat cells, which were used as a positive control, showed overexpression compared to the normal breast. Regarding primary breast carcinomas, FLI1 is significantly under expressed in all of the stages of breast cancer upon using 18S as an internal control. This FLI1 expression was correlated with ER, PR and HER2 status. In conclusion FLI1 can be exploited as a preliminary marker that can predict the status of ER, PR and HER2 in primary breast tumors.
Background: Osteoporosis (OP) is a chronic and a progressive disease characterized by low bone mass and micro-architectural deterioration of bone tissue, resulting in an increased risk of fracture. Osteocalcin is a non-collagenous protein synthesized and secreted by osteoblasts. Its main physiological functions are calcium ion homeostasis, maintain the normal bone mineralization rate, inhibit the abnormal formation of hydroxyapatite crystal, and to be involved in bone remodeling through a negative feedback mechanism.
Objective: This study was planned to evaluate serum level of bone formation marker osteocalcin (OC) in postmenopausal women with and without primary osteoporosis; and study the correlation between serum osteocalcin level
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Background: Multiple tumors in the nervous system is a rare event..
Patient & Method: .A forty two years old male who was enjoying completely healthy life presented with one week history of a single attack of confusion .he was presented with double tumour in the brain operated up on our department by craniotomy.
Results: His neurological clinical examination was negative. A CT scan & MRI of the brain showed two intracranial space occupying lesions. A solid right frontal lesion and another cystic lesion in the third ventricle. . The pathology proved the frontal lesion to be a meningioma while the third ventricular tumour was colloid cyst. Post operative period was uneventful. Follow up for few months showed no complaint.
A local isolate Bacillus subtilis was used, which producing
thennophilic complex enzyme having similar activity of endogluganase
enzyme ( Endo-l,4-B-Dglucanase ).
Partially digested chromosomal DNA of Bacillus subtilis by Eco
Rl restriction enzyme randomly cloned into Eco Rl pSU10l shuttle vector. The resulted hybrid plasmid was transformed into protoplast of
Streptomyces sp. SH-H.
The result revealed  
... Show MoreSegmentation is one of the most computer vision processes importance, it aims to understand the image contents by partitioning it into segments that are more meaningful and easier to analyze. However, this process comes with a set of challenges including image skew, noise, and object clipping. In this paper, a solution is proposed to address the challenges encountered when using Optical Character Recognition to recognize mathematical expressions. The proposed method involves three stages: pre-processing, segmentation, and post-processing. During pre-processing, the mathematical expression image is transformed into a binary image, noise reduction techniques are applied, image component discontinuities are resolved, and skew corre
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Endometriosis is a painful disease that affects around 5% of women of reproductive age. In endometriosis, ectopic endometrial cells or seeded endometrial debris grow in abnormal locations including the peritoneal cavity. Common manifestations of endometriosis include dyspareunia, dysmenorrhea, chronic pelvic pain and often infertility and symptomatic relief or surgical removal are mainstays of treatment. Endometriosis both promotes and responds to estrogen imbalance, leading to intestinal bacterial estrobolome dysregulation and a subsequent induction of inflammation.
In the current study, we investigated the linkage be
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Banned temporarily divers has increased greatly in the society and for silly reasons.
This issue aroused a great controversy .There are so many motivations to Aleve deep in it.
There are so many approach hes to talk it . It deserves to be studied in a simple way but
thoroughly and comprehensively .Dune to this great importees and to its spread among
married couples for their agnorance concerning its voles' and dangers .
I have been stimulated and encouraged to go through and close read its details
aleomplish this research.
It is a olevided in to an introduction and three chapters :
1-chapter one : defines the terminology of banned temporarily clearer's and it legal situation .
2-chapter two : Terms of banned te
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