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Effects of cavity depth (moderate vs. deep with pulp exposure) on the release of prostaglandin E2 and nitric oxide in rat mandibular incisors
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Background/objectives: Inflammatory mediators such as prostaglandin E2 (PGE2) and nitric oxide (NO) are key indicators of pulp response to mechanical trauma. However, the influence of cavity depth on their release dynamics remains unclear. This study aimed to evaluate the effects of different cavity depths—moderate (without pulp exposure) and deep (with pulp exposure)—on the release of PGE2 and NO in the pulp tissue of rat mandibular incisors at two time intervals (3 and 9 h).Methods: In total, 40 male Wistar rats were divided into two main groups (n = 20) based on cavity depth. A split-mouth design was used, with cavities of different depths prepared on the left mandibular incisors, leaving the right incisors without cavities as controls. All the prepared cavities were sealed with glass ionomer filling until 3 or 9 h (n = 10), when pulp tissue was removed. Homogenates were prepared and analyzed by ELISA for PGE2 and NO levels.Results: Cavities without pulp exposure elicited 2.1-fold higher PGE2 (median: 3.44 vs. 1.81 ng/mL; p < 0.001) and 1.3-fold higher NO (median: 55.45 vs. 43.76 μmol/L; p < 0.01) compared to exposed cavities at 3 h—a paradoxical finding suggesting intact pulp architecture potentiates acute inflammatory signaling. This disparity persisted at 9 h (PGE2: 3.18 vs. 1.81 ng/mL; NO: 49.94 vs. 44.98 μmol/L), though with attenuated significance (p < 0.05).Conclusion: Cavity preparation induces an early inflammatory response in the pulp, as indicated by increased PGE2 and NO levels. The inflammatory response was more pronounced in cavities without pulp exposure, suggesting that maintaining pulp integrity favors a regulated inflammatory response conducive to healing, while exposure may promote irreversible damage.

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Publication Date
Sat Dec 31 2022
Journal Name
College Of Islamic Sciences
Moderation in moderate Islamic thoughts
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Abstract :

The study seeks to highlight the importance of moderate religious discourse and dialogue and the rejection of extremist discourse that renews the crises and wounds of history.  And that is through the means and efforts exerted, which is changing the extremist religious discourse to a moderate religious discourse, as well as calling on religious figures, whether they are followers of Judaism, Christianity or Islam, to search for a common ground for understanding and coexistence, because extremism in the name of God is the enemy for all and not for countries or religions in particular.

 Also, through the necessity of confronting terrorist threats by making more efforts

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Publication Date
Sat Dec 31 2022
Journal Name
College Of Islamic Sciences
Moderate discourse and civil peace
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Abstract

  Currently, the “moderate discourse and civil peace” represents a rich and important topic for scholars, due the rise of waves of extremism and Islamophobia campaigns, and what that leads to in term of imbalance in relations between nations and peoples.

Based on that, the research approach was to tackle the culture of hatred and calls for the clash of civilizations.

In order to contribute to solving these problems caused by cultural and religious prejudices, I decided to address the topic of “moderate discourse and civil peace” through two essential axes:

  • Features of moderate religious discourse
  • The role of moderate discourse in establishing communit

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Publication Date
Fri Mar 31 2017
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Effect of Temperature on the Stability and Release Profile of Ibuprofen Microcapsules
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The stability and releasing profile of 2:1 core: wall ratio ibuprofen microcapsules prepared by aqueous coacervation (gelatin and acacia polymers coat) and an organic coacervation methods (ethyl cellulose and sodium alginate polymers coat) in weight equivalent to 300mg drug, were studied using different storage temperatures 40°C, 50°C ,60°C and refrigerator temperature 4°C in an opened and closed container for three months (releasing profile) and four months (stability study).It was found that, these ibuprofen microcapsules were stable with expiration dates of 4.1 and 3.1 years for aqueous and an organic method respectively.Aqueous prepared ibuprofen microcapsules were found more stable than those microcapsules prepared by or

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Publication Date
Sat Oct 01 2016
Journal Name
World Journal Of Pharmaceutical Research
EFFECT OF LEVETIRACETAM ON THE CEREBRAL CORTEX OF NEWBORN RAT
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Background: Levetiracetam is a member of the new antiepileptic drugs and has a broad spectrum effect, used as an adjunctive therapy in addition to monotherapy in the treatment of partial onset-seizures. The effect of levetiracetam on the development of embryo nervous system after maternal exposure during pregnancy has not been identified. Objective: to evaluate the effect of antiepileptic drug, levetiracetam (LEV) within its therapeutic dose 350mg/Kg body weight on albino female rat to clarify its effect on the developing cerebral cortex histologically. Material And Methods: Ten pregnant female rats were separated into two groups, control group and experimental group. They were obtained from the animal house of the high institute of inferti

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Publication Date
Sat Feb 08 2014
Journal Name
Reaction Kinetics, Mechanisms And Catalysis
Kinetic and mathematical approaches to the corrosion of mild steel in nitric acid
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Publication Date
Fri Apr 01 2016
Journal Name
Journal Of Engineering
Effect of Variation of Degree of Saturation with depth on Soil–Concrete Pile Interface in Clayey Soil
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Bearing capacity of a concrete pile in fine grained cohesive soils is affected by the degree of saturation of the surrounding soil through the contribution of the matric suction. In addition, the embedded depth and the roughness of the concrete pile surface (expressed as British Pendulum Number BPN) also have their contribution to the shear strength of the concrete pile, consequently its bearing capacity. Herein, relationships among degree of saturation, pile depth, and surface roughness, were proposed as a mathematical model expressed as an equation where the shear strength of a pile can be predicted in terms of degree of saturation, depth, and BPN. Rel

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Publication Date
Fri Sep 01 2023
Journal Name
Iranian Journal Of Veterinary Science And Technology
Investigation of bacterial contamination with Klebsilla and E. coli in the prepucal cavity of pubertal and adult age in caprine
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Publication Date
Tue Oct 30 2018
Journal Name
Iraqi Journal Of Physics
Annealing effects on optical and structural properties of chromium oxide thin film deposited by PLD technique
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Optical properties of chromium oxide (Cr2O3) thin films which were prepared by pulse laser deposition method, onto glass substrates. Different laser energy (500-900) mJ were used to obtain Cr2O3 thin films with thickness ranging from 177.3 to 372.4 nm were measured using Tolansky method. Then films were annealed at temperature equal to 300 °C. Absorption spectra were used to determine the absorption coefficient of the films, and the effects of the annealing temperature on the absorption coefficient were investigated. The absorption edge shifted to red range of wavelength, and the optical constants of Cr2O3 films increases as the annealing temperature increased to 300 °C. X-ray diffraction (XRD) study reveals that Cr2O3 thin films are a

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Publication Date
Thu Jan 01 2015
Journal Name
Journal Of Traumatic Stress Disorders &amp; Treatment
Randomised Controlled Study Comparing Two Psychological Therapies for Posttraumatic Stress Disorder (PTSD): Emotional Freedom Techniques (EFT) vs. Narrative Exposure Therapy (NET)
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Publication Date
Tue Jun 01 2021
Journal Name
International Medical Journal
Visibility of mandibular canal on CBCT cross-sectional images in comparison with panoramic radiograph: Retrospective study
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