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Preparation, diagnosis and testing of the biological ‎activity of new complexes of Schiff bases
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‎ Sixteen new complexes with the general formula [M(L)2(H2O)2] were ‎prepared resulting from the reaction of the two new Schiff base ligands, which ‎are‏: -‏ L1= (E)-5-((2-hydroxybenzylidene)amino)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one)‎ L2 = (E)-5-((2-hydroxy-3-methoxybenzylidene)amino)-2-phenylpyrazolidin-3-one) ‎ ‎ With divalent metal ions (manganese, cobalt, nickel, copper, zinc, cadmium, ‎mercury) and (tetravalent platinum).‎‏ ‏ ‎ Ligands was derived from the reaction of the amine (5-amino-2-phenyl-2,4-‎dihydro-3H-pyrazol-3-one) with Salicylaldehyde and ortho-vanillin, which is ‎linked to the metal ions via the nitrogen atoms are the isomethene group and ‎the oxygen is the hydroxide group of the pyrazoline ring. The two prepared ‎ligands are distinguished by their ability to dissolve in organic solvents such as ‎alcohols, ether, acetone, chloroform, carbon tetrachloride and ethanol, and ‎their inability to dissolve in water. The prepared compounds were ‎characterized using infrared spectroscopy and spectroscopy nuclear magnetic ‎resonance, ultraviolet spectroscopy, micro-analysis of elements (C.H.N), ‎atomic absorption analysis, electrical conductivity of solutions of complexes at ‎a concentration of ‎‏1×10-3 ‏‎, the magnetic susceptibility of the complexes was ‎measured, and the effect of the solvent on the prepared compounds was ‎studied, and from the results of the measurements, the octahedral geometric ‎structure of the prepared complexes was proposed.. The inhibitory ability of ‎the prepared compounds was tested against two types of selected bacteria, ‎Staphylococcus aureus and Escherichia coli, and a type of fungus, Candida. ‎The results showed that the ability of the metal complexes to inhibit is higher ‎than the ligand‏.‏