The purpose of my thesis is to prepare four new ligands (L1-L4) that have been used to prepare a series of metal complexes by reacting them with metal ions: M=(Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II) Where succinyl chloride was used as a raw material for the preparation of bi-dented ligands (L1-L4) by reacting it with potassium thiocyanate as a first step and then reacting with (2-aminobenzothiazole, Benzylamine, 4-aminoantipyrine, Sulfamethoxazole) respectively as a second step with the use of dry acetone as a solvent, the chemical formula of the four ligands prepared in succession: N1,N4-bis(benzo[d]thiazol-2-ylcarbamothioyl)succinamide (L1) N1,N4-bis(benzylcarbamothioyl)succinamide (L2) N1,N4-bis((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl) carbamothioyl)succinamide (L3) N1,N4-bis((4-(N-(5-methylisoxazol-3-yl)sulfamoyl) phenyl) carbamo thioyl) succinamide (L4) The new ligands were identified using spectroscopic measurements that included (FT-IR spectra, UV-Vis spectra, and nuclear magnetic resonance (1H, 13CNMR) spectra, mass spectra, elemental analysis (C.H.N.S), and thermal analysis (TGA&DSC), as the results of the measurements proved to be identical to the proposed molecular formula for these ligands. A series of metal complexes for ligands was also prepared, which included seven complexes for each ligand, by adding each of the metal ions to the four ligands prepared in succession to produce the following molecular formulas: - [M2(L)Cl4] , L= L1, L2, L3, L4 (M= Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II)) The prepared complexes were diagnosed by several techniques, including the study of the infrared spectra of the prepared complexes, and when comparing those spectra with the spectra of each of the four ligands prepared in the free form, these gave clear changes, including the emergence of a new band within the fingerprint area. It was not originally present in the spectra of ligands in their free form, and this is due to the occurrence of coordination between the metal ions under study and the donor atoms, which are the oxygen atom of the (C=O) group, and the sulfur atom of the (C=S) group in the ligands. (L1-L4), while other distinct bands were obtained with clear changes in shape, intensity, and location, and this is an indication of the occurrence of a coordination process between the metal ions under study and the four prepared ligands. The percentage of metal ions in the prepared complexes was determined by flame atomic absorption spectrometry, where it was shown from the careful analysis of the elements the great agreement between the percentages calculated theoretically and obtained practically. The magnetic sensitivity results showed that some of the prepared metallic complexes have paramagnetic properties. The measurements of the molar conductivity of the prepared complexes dissolved in DMSO at a concentration of 1×10-3 M and at the laboratory temperature showed that they are of a non-electrolytic nature. The prepared complexes were also studied through solubility, melting point, and ultraviolet-visible techniques, and through the data of all the aforementioned techniques, structural formulas were proposed for the prepared complexes, through which it was found that the prepared ligands are bivalve chelating ligands that lead to their participation as ligand into complexes with a tetrahedral geometric shape for all metallic complexes under study. The research included a study evaluating the antioxidant activity of some selected metal complexes by studying the amount of radical scavenging of DPPH* compared to ascorbic acid as an antioxidant reference agent. The zinc complex showed higher activity than the nickel complex compared to standard ascorbic acid. The [Cu2(L1)Cl4] and [Co2(L1)Cl4] complexes were also tested as antibodies to inhibit the breast cancer cell line (MCF-7) and compared with the normal cell line (HdFn), where the copper complex showed the ability to inhibit the cancerous cell line compared with the cobalt complex. The molecular binding of ligands (L3) and (L4) was also studied, and their possibility of using them as drugs in the treatment of some diseases, where the ligand L3 showed better association with the active site of the enzyme than the ligand L4, and is expected to highest antimicrobial effect. Finally, the biological effect of the prepared ligands and some of their complexes on the growth of two types of bacteria, Escherichia coli and Staphylococcus aureus, was studied using DMSO solvent, where the complexes showed greater activity than the ligands against the selected types of bacteria.
Schiff bases (SBs) represent multipurpose ligands that can be prepared from the concentration of prime amines with carbonyl clusters. Creation of SB transition metal compounds via as ligands has opportunity of attaining coordination complexes of abnormal arrangement and stability. These transition metal compounds have extraordinary attention as a consequence of their dynamic portion in metalloenzymes and as biomimetic prototypical complexes as a result of their proximity to usual enzymes and proteins. These complexes are imperative in medicinal disciplines owing to their widespread range of biological actions. They mostly exhibit organic actions involving antifungal, antibacterial, antitumor, antidiabetic, herbicidal, antiproliferative, ant
... Show MoreNi2O3 nanomaterial, a phase of nickel oxide, is synthesized by a simple chemical process. The pure raw materials used in the present process were nickel chloride hexahydrate NiCl2.6H2O and potassium hydroxide KOH by utilizing temperature at 250 oC for 2 hour. The structural, morphological and optical properties of the synthesized specimens of Ni2O3 were investigated employing diverse techniques such as XRD, AFM, SEM and UV-Vis, respectively. The XRD technique confirms the presence of Ni2O3 nanomaterial with crystal size of 57.083 nm which indexing to the (2θ) of 31.82; this results revealed the Ni2O3 was a phase of nickel oxide with Nano structure. The synthesized Ni2O3 will be useful in manufacturng electrodes materials f
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In this work, we introduce a new kind of perfect mappings, namely j-perfect mappings and j-ω-perfect mappings. Furthermore we devoted to study the relationship between j-perfect mappings and j-ω-perfect mappings. Finally, certain theorems and characterization concerning these concepts are studied; j = , δ, α, pre, b, β
The development of new cephalosporins with improved activity against resistant microbes, such as, MRSA (methicillin resistant Staph. aureus), P. aeruginosa, is of high potential. Chemical synthesis of two new series of thiadiazole linked to cysteine (series 1) and cephalosporins containing thiadiazole linked to cysteine through disulfide bond (series 2) were achieved. The chemical structures of the synthesized compounds were confirmed using spectral (FT-IR, 1H-NMR) and elemental microanalysis. The incorporation of privileged chemical moieties, such as, thiadiazole, Schiff base, cysteine and sulfonamide, has been found to have great contribution to the antimicrobial activities. Compounds of series 1 (1
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A series of benzohydrazide derivatives attached to coumarin moiety at position 6 and 7 have been synthesized. The reaction of coumarin derivatives (coumarin I and II) with p-nitrophenyl hydrazine yield Schiff bases (compound1a and IIa).These Schiff bases were refluxed with benzoyl chloride to give benzohydrazide derivatives of coumarin substituted at its 6 or 7 nucleus position (Ia1 and IIa1).The reaction and the purity of the products were checked by thin layer chromatography (TLC). The structures of the final compounds and their intermediates were confirmed by their melting points, infra red spectroscopy, and elemental microanalysis(CHN).
Compounds (Ia1 and IIa1) were evaluated for&n
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In this work, novel compounds of hydrazones derived from (2,4-dinitrophenyl) hydrazine were synthesized. Benzamides derivatives and sulfonamides derivatives were prepared from p-amino benzaldehyde. Then these compounds were condensed with (2,4-dinitrophenyl) hydrazine through Imine bond formation to give hydrazones compounds. The compounds were characterized using FT-IR (IR Affinity-1) spectrometer, and 1HNMR analyses. The majority of the compounds have a moderate antimicrobial activity against “Gram-positive bacteria staphylococcus Aureus, and staphylococcus epidermidis, Gram-negative bacteria Escherichia coli, and Klebsiella pneumoniae, and fungi species Candida albicans” using concentrations of 250 µg\ml.
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in this paper copper oxide (cuO thin films were prepared by the method of vacum thermal evaporation a pressure.
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The sorption of Cu2+ ions from synthetic wastewater using crushed concrete demolition waste (CCDW) which collected from a demolition site was investigated in a batch sorption system. Factors influencing on sorption process such as shaking time (0-300min), the initial concentration of contaminant (100-750mg/L), shaking speed (0-250 rpm), and adsorbent dosage (0.05-3 g/ml) have been studied. Batch experiments confirmed that the best values of these parameters were (180 min, 100 mg/l, 250 rpm, 0.7 g CCDW/100 ml) respectively where the achieved removal efficiency is equal to 100%. Sorption data were described using four isotherm models (Langmuir, Freundlich, Redlich-Peterson, and Radke-Prausnitz). Results proved that the pure ads
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