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Synthesis, spectral characterization and thermal ‎study of complexes of ions of some metallic ‎elements with new cyclic ligands
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The purpose of my thesis is to prepare four new ligands (L1-L4) that have been ‎used to prepare a series of metal complexes by reacting them with metal ions:‎ ‎ M=(Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II) ‎ ‎ Where succinyl chloride was used as a raw material for the preparation of ‎bi-dented ligands (L1-L4) by reacting it with potassium thiocyanate as a first ‎step and then reacting with (2-aminobenzothiazole, Benzylamine, 4-‎aminoantipyrine, Sulfamethoxazole) respectively as a second step with the use ‎of dry acetone as a solvent, the chemical formula of the four ligands prepared in ‎succession:‎ N1,N4-bis(benzo[d]thiazol-2-ylcarbamothioyl)succinamide (L1)‎ N1,N4-bis(benzylcarbamothioyl)succinamide (L2)‎ N1,N4-bis((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl) ‎carbamothioyl)succinamide (L3)‎ N1,N4-bis((4-(N-(5-methylisoxazol-3-yl)sulfamoyl) phenyl) carbamo thioyl) ‎succinamide (L4)‎ ‎ The new ligands were identified using spectroscopic measurements that ‎included (FT-IR spectra, UV-Vis spectra, and nuclear magnetic resonance (1H, ‎‎13CNMR) spectra, mass spectra, elemental analysis (C.H.N.S), and thermal ‎analysis (TGA&DSC), as the results of the measurements proved to be identical ‎to the proposed molecular formula for these ligands.‎ ‎ A series of metal complexes for ligands was also prepared, which included ‎seven complexes for each ligand, by adding each of the metal ions to the four ‎ligands prepared in succession to produce the following molecular formulas: -‎ ‎[M2(L)Cl4] , L= L1, L2, L3, L4‎ ‎(M= Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II))‎ ‎ The prepared complexes were diagnosed by several techniques, including the ‎study of the infrared spectra of the prepared complexes, and when comparing ‎those spectra with the spectra of each of the four ligands prepared in the free ‎form, these gave clear changes, including the emergence of a new band within ‎the fingerprint area. It was not originally present in the spectra of ligands in ‎their free form, and this is due to the occurrence of coordination between the ‎metal ions under study and the donor atoms, which are the oxygen atom of the ‎‎(C=O) group, and the sulfur atom of the (C=S) group in the ligands. (L1-L4), ‎while other distinct bands were obtained with clear changes in shape, intensity, ‎and location, and this is an indication of the occurrence of a coordination ‎process between the metal ions under study and the four prepared ligands.‎ ‎ The percentage of metal ions in the prepared complexes was determined by ‎flame atomic absorption spectrometry, where it was shown from the careful ‎analysis of the elements the great agreement between the percentages calculated ‎theoretically and obtained practically.‎ ‎ The magnetic sensitivity results showed that some of the prepared metallic ‎complexes have paramagnetic properties.‎ The measurements of the molar conductivity of the prepared complexes ‎dissolved in DMSO at a concentration of 1×10-3 M and at the laboratory ‎temperature showed that they are of a non-electrolytic nature.‎ ‎ The prepared complexes were also studied through solubility, melting point, ‎and ultraviolet-visible techniques, and through the data of all the ‎aforementioned techniques, structural formulas were proposed for the prepared ‎complexes, through which it was found that the prepared ligands are bivalve ‎chelating ligands that lead to their participation as ligand into complexes with a ‎tetrahedral geometric shape for all metallic complexes under study.‎ ‎ The research included a study evaluating the antioxidant activity of some ‎selected metal complexes by studying the amount of radical scavenging of ‎DPPH* compared to ascorbic acid as an antioxidant reference agent. The zinc ‎complex showed higher activity than the nickel complex compared to standard ‎ascorbic acid. The [Cu2(L1)Cl4] and [Co2(L1)Cl4] complexes were also tested as ‎antibodies to inhibit the breast cancer cell line (MCF-7) and compared with the ‎normal cell line (HdFn), where the copper complex showed the ability to inhibit ‎the cancerous cell line compared with the cobalt complex. ‎ ‎ The molecular binding of ligands (L3) and (L4) was also studied, and their ‎possibility of using them as drugs in the treatment of some diseases, where the ‎ligand L3 showed better association with the active site of the enzyme than the ‎ligand L4, and is expected to highest antimicrobial effect. ‎ ‎ Finally, the biological effect of the prepared ligands and some of their ‎complexes on the growth of two types of bacteria, Escherichia coli and ‎Staphylococcus aureus, was studied using DMSO solvent, where the complexes ‎showed greater activity than the ligands against the selected types of bacteria. ‎‏

Publication Date
Sun Mar 03 2013
Journal Name
Baghdad Science Journal
Synthesis and Identification of Some New Derivative of Trimethoprim and Paracetemol Drugs
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In this research two series of the new derivatives of Trimethoprim and paracetamol drugs have been prepared which known as a high medicinal effectiveness. Series (A) is including the interaction of diazonium salt of trimethoprim and coupling with some substituted phenol compounds (2-amino phenol, 3-ethyl phenol, 1-naphthol, 2-nitro phenol, Salbutamol). Series (B) is including the interaction coupling alkali solution of paracetamol with diazonium salt of some substituted aniline compounds (Benzedine, 2, 3-di chloro aniline, Trimethoprim, Anilinium chloride, 2-nitro- 4-chloro aniline).Chemical structures of all synthesized compounds were confirmed by UV-visible and FTIR spectroscopy.

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Publication Date
Sat Sep 01 2018
Journal Name
Journal Of Global Pharma Technology
Synthesis ,Characterization and Study of Liquid Crystalline Behavior of New Compounds Containing thiazolidin-4-one,1,2,3-triazole and benzimidazol Rings
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All new compounds synthesized by many reactions starting from a product the compounds [I]a,b from reaction of 3-phenylenediamine or 4-phenylenediamine with chloroacetyl chloride, then the compounds [I]a,b reacted with potassium thiocyanate to yield compounds [II]a,b. While the compounds[III]a,b yield from reacted the compounds [I]a,b with sodium azide then the compounds [III]a,b reacted 1,3-dipolar cycloaddition reaction with acrylic acid to give compounds [IV]a,b and the later compounds reacted with phenylene diamine to product benzimidazole compounds [V]a,b . In addition to synthesized acid chloride compounds [VI]a,b by reacted the compounds [IV]a,b with thionyl chloride .Finally reacted the compounds [VI]a,b with different aromatic amine

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Publication Date
Sun Jan 01 2012
Journal Name
Third Scientific Conference / College Of Science - University Of Diyala -2012 A Scientific Referred Journal Published By College Of Science University Of Diyala July
Synthesis, Characterization, Schiff Base phenyl2-(2-hydroxybenzylidenamino)benzoate and its complexes with Pr III , Cr and IIILa , III
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The aim of the work is the synthesis and characterization of the tridentate Schiff base (HL) containing (N and O) as donor atoms type (ONO). The ligand is: (HL) phenyl 2-(2-hydroxybenzylidenamino)benzoate This ligand was prepared by the reaction of (phenyl 2-aminobenzoate) with salicylaldehyde under reflux in ethanol and few drops of glacial acetic acid which gave the ligand (HL). The prepared ligand was characterized by (FT IR,UV–Vis) spectroscopy, Elemental analysis of carbon, hydrogen and nitrogen (C.H.N.) and melting point. The ligand was reacted with some metal ions under reflux in ethanol with (1 metal :2 ligand )mole ratio which gave complexes of the general formula: Pr III , Cr and III La III [M(L)2]Cl , M = Products were found to

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Publication Date
Wed Jul 01 2015
Journal Name
Journal Of Saudi Chemical Society
Synthesis, characterization and comparative study the microbial activity of some heterocyclic compounds containing oxazole and benzothiazole moieties
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Publication Date
Sun Oct 01 2023
Journal Name
Baghdad Science Journal
Synthesis and Characterization of Grafted Chitosan Blending with Polyvinyl alcohol / Nanocomposite and Study Biological Activity
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The study of biopolymers and their derivative materials had received a considerable degree of attention from researchers in the preparation of novel material. Biopolymers and their derivatives have a wide range of applications as a result of their bio-compatibility, bio-degradability and non-toxicity. In this paper, chitosan reacted with different aldehydes(2,4 –dichloro- benzaldehyde or 2-methyl benzaldehyde), different ketones (4-bromoacetophenone or 3-aminoacetophenone) to produce chitosan schiff base (1-4) . Chitosan schiff base (1-4) reacted with glutaric acid or adipic acid in acidic media in distilled water according to the steps of Fischer and Speier to produce compounds (5-12)

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Publication Date
Mon Jun 01 2020
Journal Name
Life Sciences
Synthesis, characterization and anticancer activity in vitro evaluation of novel dicyanoaurate (I)-based complexes
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Publication Date
Sat Jun 20 2020
Journal Name
International Journal Of Pharmaceutical Research
Synthesis , Physicochemical Studies and biological estimation of new mixed ligand complexes from hetrocyclic compounds
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The purpose of this research is to synthesize a new mixed ligand Schiff base complexes of Co(II),Ni(II),Cu(II), Zn(II), Cd(II), and Hg(II),which are formulated from the Schiff base (L) that resulted from orthophathalaldehyde (2-PA) with 4-chloroaniline(4-NA). Diagnosis of prepared Ligand and its complexes is done by spectral methods as 1H–NMR, mass spectrometer, FTIR, UV-Vis, molar conductance, elemental microanalyses, atomic absoption and magnetic susceptibility. The analytical studyofall new complexes has shown octahedral geometries. Organic performance study of ligand Schiff base and its complexes reveals different activities agansit four types of bactria; two gram (+) and two gram (-) .

Publication Date
Sun Jun 06 2010
Journal Name
Baghdad Science Journal
Study of pollution by heavy elements in some parts of Baghdad
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The objective of the present work is to measuring the concentration of heavy elements (Pb, Cd, Zn, As) in Baghdad's soil city and indication to the probable sources of pollution as well as comparing the concentration of heavy elements with local and international ranges. The Sampling and analyzing conducted in the present work included ( 15 ) Samples from Baghdad city ( three samples for each location ).The rates of heavy elements in soil samples were as following:. Pb ( 67.5 ) ppm, Cd ( 4.11 ) ppm , Zn ( 77.9 ) ppm , As ( 4.64 ) ppm. According to the results, we find increasing in the concentrations of the heavy elements ( Pb, Cd, Zn ) in soils and decreasing in ( As ).We conclude that the main reason behind the in

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Publication Date
Thu Sep 16 2010
Journal Name
Al-mustansiriyah
Synthesis, Spectroscopic and Biological Studies of Some Metal Complexes with 1, 2 bis-(ortho amino phenyl thiol)-ethane.
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Publication Date
Fri Nov 03 2023
Journal Name
Journal Of Applied Sciences And Nanotechnology
Versatile Applications of Mannich Base Ligands and their Metal ‎Complexes: A Review Article
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Mannich base is a versatile compound that can be easily modified to introduce different functional groups, allowing for the creation diverse selection of items with varying features. Additionally, the Mannich reaction is a valuable tool in organic synthesis, due to the fact it provides an effortless and efficient approach for synthesizing C-N bonds. Overall, The Mannich base and even its derivatives are essential in many aspects of chemistry and its complexes are in the pharmaceutical industry. Studies have revealed that it shows good anti-cancer, anti-mycobacterial, remarkable anti-HIV, anti-tubercular, anti-convulsant, anti-fungal, antiviral, antitumor, cytotoxic activities and in industrial applications such as in the creation of polymer

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