The purpose of my thesis is to prepare four new ligands (L1-L4) that have been ‎used to prepare a series of metal complexes by reacting them with metal ions:‎ ‎ M=(Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II) ‎ ‎ Where succinyl chloride was used as a raw material for the preparation of ‎bi-dented ligands (L1-L4) by reacting it with potassium thiocyanate as a first ‎step and then reacting with (2-aminobenzothiazole, Benzylamine, 4-‎aminoantipyrine, Sulfamethoxazole) respectively as a second step with the use ‎of dry acetone as a solvent, the chemical formula of the four ligands prepared in ‎succession:‎ N1,N4-bis(benzo[d]thiazol-2-ylcarbamothioyl)succinamide (L1)‎ N1,N4-bis(benzylcarbamothioyl)succinamide (L2)‎ N1,N4-bis((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl) ‎carbamothioyl)succinamide (L3)‎ N1,N4-bis((4-(N-(5-methylisoxazol-3-yl)sulfamoyl) phenyl) carbamo thioyl) ‎succinamide (L4)‎ ‎ The new ligands were identified using spectroscopic measurements that ‎included (FT-IR spectra, UV-Vis spectra, and nuclear magnetic resonance (1H, ‎‎13CNMR) spectra, mass spectra, elemental analysis (C.H.N.S), and thermal ‎analysis (TGA&DSC), as the results of the measurements proved to be identical ‎to the proposed molecular formula for these ligands.‎ ‎ A series of metal complexes for ligands was also prepared, which included ‎seven complexes for each ligand, by adding each of the metal ions to the four ‎ligands prepared in succession to produce the following molecular formulas: -‎ ‎[M2(L)Cl4] , L= L1, L2, L3, L4‎ ‎(M= Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II))‎ ‎ The prepared complexes were diagnosed by several techniques, including the ‎study of the infrared spectra of the prepared complexes, and when comparing ‎those spectra with the spectra of each of the four ligands prepared in the free ‎form, these gave clear changes, including the emergence of a new band within ‎the fingerprint area. It was not originally present in the spectra of ligands in ‎their free form, and this is due to the occurrence of coordination between the ‎metal ions under study and the donor atoms, which are the oxygen atom of the ‎‎(C=O) group, and the sulfur atom of the (C=S) group in the ligands. (L1-L4), ‎while other distinct bands were obtained with clear changes in shape, intensity, ‎and location, and this is an indication of the occurrence of a coordination ‎process between the metal ions under study and the four prepared ligands.‎ ‎ The percentage of metal ions in the prepared complexes was determined by ‎flame atomic absorption spectrometry, where it was shown from the careful ‎analysis of the elements the great agreement between the percentages calculated ‎theoretically and obtained practically.‎ ‎ The magnetic sensitivity results showed that some of the prepared metallic ‎complexes have paramagnetic properties.‎ The measurements of the molar conductivity of the prepared complexes ‎dissolved in DMSO at a concentration of 1×10-3 M and at the laboratory ‎temperature showed that they are of a non-electrolytic nature.‎ ‎ The prepared complexes were also studied through solubility, melting point, ‎and ultraviolet-visible techniques, and through the data of all the ‎aforementioned techniques, structural formulas were proposed for the prepared ‎complexes, through which it was found that the prepared ligands are bivalve ‎chelating ligands that lead to their participation as ligand into complexes with a ‎tetrahedral geometric shape for all metallic complexes under study.‎ ‎ The research included a study evaluating the antioxidant activity of some ‎selected metal complexes by studying the amount of radical scavenging of ‎DPPH* compared to ascorbic acid as an antioxidant reference agent. The zinc ‎complex showed higher activity than the nickel complex compared to standard ‎ascorbic acid. The [Cu2(L1)Cl4] and [Co2(L1)Cl4] complexes were also tested as ‎antibodies to inhibit the breast cancer cell line (MCF-7) and compared with the ‎normal cell line (HdFn), where the copper complex showed the ability to inhibit ‎the cancerous cell line compared with the cobalt complex. ‎ ‎ The molecular binding of ligands (L3) and (L4) was also studied, and their ‎possibility of using them as drugs in the treatment of some diseases, where the ‎ligand L3 showed better association with the active site of the enzyme than the ‎ligand L4, and is expected to highest antimicrobial effect. ‎ ‎ Finally, the biological effect of the prepared ligands and some of their ‎complexes on the growth of two types of bacteria, Escherichia coli and ‎Staphylococcus aureus, was studied using DMSO solvent, where the complexes ‎showed greater activity than the ligands against the selected types of bacteria. ‎‏