Gaucher disease (GD), which is due to a deficiency in the lysosomal enzyme β-glucocerebrosidase, is a rare genetic disorder. It is characterized by a wide variety of clinical manifestations and severity of symptoms, making it difficult to manage. A cross-sectional hospital-based genetic study was undertaken with 32 pediatric patients. We recruited 21 males and 11 females diagnosed with GD, with a male-to-female ratio of 1.91:1. The mean age of the study population was 8.79 ± 4.37 years with an age range from 8 months to 17 years. We included patients on clinical evaluation from 2011 to 2019. An enzyme assay test was used to measure β-glucosidase enzyme activity in leukocytes and the GBA gene study was performed by polymerase chain reaction technique. We found GD type 1 in 27 (84.37%) participants, GD type 3 in five (15.63%) participants, while none classified as GD type 2. The dominant mutation in GD 1 was N370S in 81.5%, of which two-thirds were homozygous. The second common mutation in this type of disease (L444P) was present in nine cases (40.9%), two of whom were homozygous (9.9%). Meanwhile, R463C was present in six cases (27.27%), of whom one was homozygous. In GD 3, the dominant mutation was L444P as seen in 80% of the patients followed by N370S and R463C in 20%. This study shows that the most common mutant allele in this study was N370S, followed by L444P. Further large-scale studies with more advanced designs are recommended to explore the sequences of GBA genes.
The modern systems that have been based upon the hash function are more suitable compared to the conventional systems; however, the complicated algorithms for the generation of the invertible functions have a high level of time consumption. With the use of the GAs, the key strength is enhanced, which results in ultimately making the entire algorithm sufficient. Initially, the process of the key generation is performed by using the results of n-queen problem that is solved by the genetic algorithm, with the use of a random number generator and through the application of the GA operations. Ultimately, the encryption of the data is performed with the use of the Modified Reverse Encryption Algorithm (MREA). It was noticed that the
... Show MoreConstruction contractors usually undertake multiple construction projects simultaneously. Such a situation involves sharing different types of resources, including monetary, equipment, and manpower, which may become a major challenge in many cases. In this study, the financial aspects of working on multiple projects at a time are addressed and investigated. The study considers dealing with financial shortages by proposing a multi-project scheduling optimization model for profit maximization, while minimizing the total project duration. Optimization genetic algorithm and finance-based scheduling are used to produce feasible schedules that balance the finance of activities at any time w
Enterobius vermicularis infection is considered as one of the important causes of anaemia and malnutrition among children. This topic has recently received an increased amount of attention. The objective of this study is to evaluate the demographical, anthropometrical, nutritional, and haematological status of E. vermicularis infection among children. This study was conducted in Al Diwaniyah province, south of Iraq, for the period of October 2020 to the end of January 2021. The study included 122 children from both genders (males, n= 61, and females, n=61) and their ages ranged between 1 and 14 years. Nutritional status, body mass index (BMI), BMI percentile, and weight- for- age Z score were evaluated for some particip
... Show MoreEnterobius vermicularis infection is considered as one of the important causes of anaemia and malnutrition among children. This topic has recently received an increased amount of attention. The objective of this study is to evaluate the demographical, anthropometrical, nutritional, and haematological status of E. vermicularis infection among children. This study was conducted in Al Diwaniyah province, south of Iraq, for the period of October 2020 to the end of January 2021. The study included 122 children from both genders (males, n= 61, and females, n=61) and their ages ranged between 1 and 14 years. Nutritional status, body mass index (BMI), BMI percentile, and wei
... Show MoreRespiratory Syncytial Virus is the most common cause of acute viral bronchiolitis and pneumonia in infants and young children. This study is designed to examine the presence of anti-RSV IgM and IgA antibodies in infants and young children aged between 2 months up to 5 years old. ELISA was used to examine the levels of IgM and IgA antibodies in the serum samples from 90 individuals (60 are with respiratory symptoms and 30 healthy as controls). The results were analysed by systematically dividing those individuals into two groups according to their age and clinical status. The age groups included infant between 2 months and 1 year of age and young children between 2-5 years whereas the clinical grouping includes the severity of infection o
... Show MoreThe estimation of the parameters of linear regression is based on the usual Least Square method, as this method is based on the estimation of several basic assumptions. Therefore, the accuracy of estimating the parameters of the model depends on the validity of these hypotheses. The most successful technique was the robust estimation method which is minimizing maximum likelihood estimator (MM-estimator) that proved its efficiency in this purpose. However, the use of the model becomes unrealistic and one of these assumptions is the uniformity of the variance and the normal distribution of the error. These assumptions are not achievable in the case of studying a specific problem that may include complex data of more than one model. To
... Show MoreBy the time we conducted the current study,- COVID-19 epidemic has already become a global challenge, paralyzing socio-economic activity dramatically.
Hence , this study aimed to identify the most valuable prognostic indicators for COVID19 patients' early and accurate diagnosis by comparing laboratory biomarkers like C -reactive protein between non-severe and severe groups of patients. Depending on clinical symptoms, ---337 COVID-19 patients were enrolled at the Basra City Hospital from March 29 to April 29,2020 were classified into severe and non severe groups.
A total of 337 patients were diagnosed with C
... Show MoreLeishmaniasis is a transmissible infection brought about by an obligatory intracellular protozoan from the genus Leishmania. It occurs worldwide in tropical and subtropical regions and can be burdensome in resource-constrained countries. The infection ranges in severity from mild cutaneous lesions to more severe and sometimes life-threatening visceral and distorting mucocutaneous sicknesses. Importantly, cutaneous leishmaniasis (CL) is prevalent in the Middle East with a pooled prevalence of 12%. It imposes a significant health and socioeconomic burden
According to so many previous studies, lack of sufficient information during prescribing steps may lead to medication errors. Thus, the presence of the clinical pharmacist during routine rounding process in the ward with intervention of patient care plan may reduce the probability of adverse drug events (ADEs).This study evaluate role of the clinical pharmacists, as a member of medical team with the physician, on ADEs and report their interventions in the internal medicine unit. This study was designed to compare between two groups of patients, those receiving care from a rounding team (physician, nurse, and clinical pharmacist) (study or intervention group with 51 patient); and those receiving c
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