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A Pan-Inhibitor for Protein Arginine Methyltransferase Family Enzymes

Protein arginine methyltransferases (PRMTs) play important roles in transcription, splicing, DNA damage repair, RNA biology, and cellular metabolism. Thus, PRMTs have been attractive targets for various diseases. In this study, we reported the design and synthesis of a potent pan-inhibitor for PRMTs that tethers a thioadenosine and various substituted guanidino groups through a propyl linker. Compound II757 exhibits a half-maximal inhibition concentration (IC50) value of 5 to 555 nM for eight tested PRMTs, with the highest inhibition for PRMT4 (IC50 = 5 nM). The kinetic study demonstrated that II757 competitively binds at the SAM binding site of PRMT1. Notably, II757 is selective for PRMTs over a panel of other methyltransferases, which can serve as a general probe for PRMTs and a lead for further optimization to increase the selectivity for individual PRMT.

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Publication Date
Sun Sep 05 2010
Journal Name
Baghdad Science Journal
Chemotherapy Effects on the Activities of Some Purine Metabolic Enzymes in Sera of Ovarian Cancer Patients

Adenosine deaminase (ADA; Ec: 3.5.4.4), 5´- Nucleotidase (5´– NT; Ec: 3.1.3.5), and AMP – amino hydrolase (AMP – deaminase AMPDA; Ec: 3.5.4.6) activities were measured in sera of ovarian cancer patients before surgery, and after chemotherapy. The results indicated that ADA specific activity increased significantly (P<0.05), while 5´-NT and AMPDA specific activity decreased significantly (P<0.05) in ovarian cancer patients before surgery in comparison with those of their corresponding control women and benign tumors groups. When the activities of these enzymes were measured after chemotherapy, a significant decrease (P<0.05) in ADA activity, and a significant increase (P<0.05) in 5´- NT and AMPDA activities w

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Publication Date
Sat Mar 25 2023
Journal Name
Journal Of Biomechanical Science And Engineering
THE ASSOCIATION OF DAZ PROTEIN WITH AZOOSPERMIA IN IRAQI INFERTILE MEN

A disease of the reproductive system known as "infertility" is characterized by the inability to conceive after twelve months or more of sexual activity. This study was carried out to investigate the level of the DAZ protein in “Azoospermia” Iraqi patients. One hundred and fifty human blood samples were collected from different regions in Baghdad governorate include (private medicals Labs and “high institute for infertility diagnosis” assisted reproductive techniques and Kamal Al- Samara'ay IVF Hospital). The control group (fertile) consists of 50 males with an age range between 22-51 years old, while the patient (infertile group) consists of 100 sample males with ages ranging between 25-51 years old. The correlation of mean age for

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Publication Date
Sat Sep 30 2023
Journal Name
Iraqi Journal Of Science
C-reactive Protein of Clinical Outcomes in COVID-19 Basra Patients

     By the time we conducted the current study,- COVID-19 epidemic has already become a global challenge, paralyzing socio-economic activity dramatically.

 Hence   , this study aimed to identify the most valuable prognostic indicators for COVID19 patients' early and accurate diagnosis by comparing laboratory biomarkers like C -reactive protein between non-severe and severe groups of patients. Depending on clinical symptoms, ---337 COVID-19 patients were enrolled at the Basra City Hospital from March 29 to April 29,2020   were classified into severe and non severe groups.

        A total of 337 patients were diagnosed with C

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Publication Date
Fri Jan 26 2024
Journal Name
Iraqi Journal Of Science
Plasmid Role in Crystals Protein Production in Locally Isolated Bacillus Thuringiensis

The ability of crystals protein production was studied in local isolate Bacillus
thuringiensis by microscope examination, and the crystals protein production were seen
after 48 hour from growth starting, the study of plasmid profile of the isolate using gel
electrophoresis technique in 0.7% of agaros gel, revealed that it had one Mega plasmid
band, the plasmid role in production of crystals protein was studied by using conjugation experiments, that they applied on the local isolate B. thuringiensis which was crystals
protein producer and Rifamycin sensitive as donor cells, with Bacillus spp. which didn’t
produce crystals protein and Rifamycin resistance as recipient cells. Conjugation
experiments assured the transm

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Publication Date
Wed Dec 14 2016
Journal Name
Journal Of Baghdad College Of Dentistry
Detection of Granulocyte Chemotactic Protein 2 in Serum of Periodontitis Patients

Background: Chronic periodontitis defined as “an infectious inflammatory disease within supporting tissues of the teeth, progressive attachment loss and bone loss". Aggressive periodontitis is rare which in most cases manifest themselves clinically during youth. It characterized by rapid rate of disease progression .Pro-inflammatory chemokines organized inflammatory responses. Granulocyte chemotactic protein 2 is involved in neutrophil gathering and movement. The purpose of the study is to detect serum of Granulocyte Chemotactic Protein 2 and correlate to periodontal condition in patients with chronic periodontitis, Aggressive periodontitis and Healthy Control subjects and measurement the count of neutrophils for the studied groups. S

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Publication Date
Mon Feb 13 2023
Journal Name
Journal Of Educational And Psychological Researches
Family Violence Directed Against the Kindergarten Child and Its Relationship to Some Variables

The research aims at identifying the level of family violence directed against the kindergarten child, as well as to identify the significance of the difference in family violence directed against the kindergarten child according to the gender variable

(male-female). It aims also to identify the significance of the difference in family violence directed against the kindergarten child according to the Stage variable (kindergarten-pre-primary). The researcher employed the descriptive correlative approach to conduct the study. The research sample was chosen in a simple random way, as the number of the participants was (130) boys and girls, with (70) males and (60) females, distributed according to the stage with (66) participants in

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Publication Date
Mon Jul 01 2013
Journal Name
Journal Of The Faculty Of Medicine Baghdad
The Relationship between Family History and C-peptide Level in Type2 Diabetic Patients

Background: Family history of type 2 diabetes is a major risk factor for type 2 diabetes. Type 2 diabetes is characterized by progressive β-cell dysfunction; many investigators have used C peptide levels as a biomarker of β-cell function.

Objective: the current study was design to investigate the impact of family history on biochemical characteristics (c-peptide, HbA1c, lipid profile, insulin secretion, insulin sensitivity and insulin resistance.

J Fac Med Baghdad

2013; Vol.55, No .3

Received Feb .2013

Accepted July.2013

Subjects and me

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Publication Date
Sun Feb 27 2022
Journal Name
Iraqi Journal Of Science
On the Dynamics of One Parameter Family of Functions f_k (x)=kcsc(x)

     In this research, we study the dynamics of one parameter family of meromorphic functions . Furthermore, we describe the nature of fixed points of the functions in ,and we explain the numbers of real fixed points depending on the critical point . So, we develop some necessary conditions for the convergence of the sequence when .

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Publication Date
Tue Dec 20 2022
Journal Name
Bulletin Of The Iraq Natural History Museum (p-issn: 1017-8678 , E-issn: 2311-9799)
FIRST RECORD OF TWO PARASITOID WASPS OF THE FAMILY CHALCIDIDAE (HYMENOPTERA) IN IRAQ

The family Chalcididae (Order: Hymenoptera) is known as one of the large chalcidoid wasps with some distinct morphological characters. The first occurrence of two parasitoid species belonging to this family was reported in the Al-Husayniya district Karbala Province, Iraq; which are: Brachymeria podagrica (Fabricius, 1787) and Chalcis myrifex (Sulzer, 1776). Both species were collected by using the sweeping net from orchards during July 2020.

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Publication Date
Sun Jul 01 2018
Journal Name
Journal Of Educational And Psychological Researches
Family violence and its impact on the educational achievement of primary school children

The research included four chapters starting with the chapter dealing with the problem of child abuse which was one of the most important educational and social problems faced by children from their parents or family members. The most common forms of abuse are physical and psychological violence. The problem of school delays is also one of the most important educational and psychological issues that concern educators, which occur because of violence and neglect of the family. The study pointed out that domestic violence is one of the issues that has started to alarm both the global and local communities, because childhood is one of the most important stages of the human development system, which is healthy in terms of physical, mental, p

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