Endometriosis is an estrogen dependent inflammatory disorder plays a pivotal role in the reproductive system of the females which regarded as one of the most important gynecological disorders due to it is a key cause of infertility for women and also it has a remarkable impact on the women's life quality. Indeed, environmental pollution have an extremely importance in the etiology of endometriosis. Hence, the present article submits an abbreviated literature review to the biochemical role of environmental pollutants in the etiology and development of endometriosis. Anyway, this review article represented the major environmental pollutants: the organic pollutants of air, heavy metals, gaseous pollutants and the particulate matter. The aim of the present review article is to highlight the biochemical role of the environmental pollutants as risk factors for endometriosis by focusing on different information from researches and articles within this field by linking between the data and conclusions resulted from previous and recent studies. From the literature review , the present theoretical paper highlighted the biochemical role of the different of environmental pollution in the etiology and development of endometriosis : the organic compounds that influence the female reproductive system , heavy metals which accumulate in water , soil and food , the gaseous pollutants which trigger the oxidative stress , particulate matters that linked with the higher level of prolactin hormone and any pollutant factor in the life style may contribute to the etiology and development of endometriosis. Every type of environmental pollutants has a specific impact in this context but in Iraq , the heavy metals and gaseous pollutants play the key role because they directly linked with the Wars results and the waste products of the electrical private generators.