The primary goal of root canal treatment (RCT) is to expel the presence of any necrotic or vital tissue, microbes and their byproducts from the canal space before press forward with the following steps of the RCT procedures. Although this is difficult to attain, various strives had been practiced by employing chemical and mechanical methods to eliminate as much microorganisms as possible and make the canal space valid for the obturation materials to be received. The aim of this review is to demonstrate some of what new remedies that could be used as root canal disinfectant by summarizing the recent studies regarding the efficacy of different natural products against the most persistence microbiota that could be responsible for most of the failures after RCT. A comprehensive search has been performed in English language on published resources using Pub Med, Google Scholar, and Research Gate databases from 2010 to Dec 2024 by using the keywords: “root canal irrigant”, “cinnamon”, “neem oil”, “propolis”, “triphala” and “Enterococcus faecalis”.  Thirty-two papers adopted in this review. Endnote reference management software was used for organization of citations. natural remedies demonstrated potential in reducing bacterial count especially when using synergism of various natural and chemical products, it shows remarkable effect in targeting resistant microbiota such Enterococcus faecalis nevertheless it must undergo comprehensive preclinical and clinical trials to substantiate the results before they can conclusively be recommended as intracanal irrigating solutions. Herbs are generally harmless when appropriately used, but they can be hazardous if taken incorrectly.