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PLEIOTROPIC EFFECTS OF ATORVASTATIN ON PRO-INFLAMMATORY CYTOKINES IN NEWLY DIAGNOSED IRAQI PATIENTS WITH TYPE 2 DIABETES MELLITUS

Objective: Atorvastatin therapy is now recommended for reduction of cardiovascular risk in type 2 diabetic patients (T2DM), based on convincing evidence of reductions in mortality and vascular events in major clinical outcome trials. The aim is to evaluate the effects of atorvastatin on proinflammatory markers (TNF-α, IL-6), HbA1c andleptin in obese patients with type 2 diabetes. Methods: Sixty fivenewly diagnosed T2DM patients were randomly allocated into 2 groups; group I treated with metformin only; in group II atorvastatin was added with metformin. Twenty healthy subjects were enrolled as control group. While maintaining their usual eating habits, fasting blood samples were collected at baseline and after 12 weeks of treatment. Results: HbA1c levelswere decreased significantlyonly in group I compared with baseline value; while serum levels of leptin, TNF-α and IL-6 were decreased significantly in both groups compared to baseline values. Conclusion: Atorvastatin is effective in reducing leptin and pro-inflammatory cytokines levels but associated with an increased risk of worsening HbA1c in patients with T2DM.

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Publication Date
Sun Jan 01 2023
Journal Name
Medical Journal Of Babylon
Evaluation of the Salivary Levels of Interleukin-17 and Galectin-3 in Patients with Periodontitis and Type 2 Diabetes Mellitus

Background: Periodontitis and type 2 diabetes mellitus are both considered as a chronic disease that affect many people and have an interrelationship in their pathogenesis. Objective: The aim is to evaluate the salivary levels of interleukin-17 (IL-17) and galectin-3 in patients with periodontitis and type-2 diabetes mellitus. Materials and Methods: The samples were gathered from 13 healthy (control group) and 75 patients split into 3 groups, 25 patients with type 2 diabetes mellitus and healthy periodontium (T2DM group), 25 patients with generalized periodontitis (P group), and 25 patients with generalized periodontitis and type 2 diabetes mellitus (P-T2DM group). Clinical periodontal parameters were documented. The concentration of IL-17

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Publication Date
Mon Oct 01 2012
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Echocardiogrhphic assessment of the effect of type (2) Diabetes mellitus on cardiac performance

Background: Diabetes mellitus (DM) causes damaging effects on the cardiac function; these effects can be observed on the diastolic performance of the heart reflected on the change in transmitral blood velocity, the cardiac wall and septum thickness.
Objectives: The present study was to assess the diastolic and systolic cardiac muscle performance for patients with type 2 diabetes mellitus compared with control individuals and to evaluate the index of myocardial performance.
Patients and Methods: The study involved 97 patients (35 male and 62 female of average age of 56.2 ±10.755) of type 2 diabetes mellitus (DM), they were investigated for their left ventricle performance and compared with 51 normal in

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Publication Date
Tue Jan 02 2007
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Beta-Carotene, Glycemic Control And Dyslipidemia In Type 2 Diabetes Mellitus

Background : Diabetes mellitus is a stressful condition in which the increased production of free radicals impairs the generation of naturally occurring antioxidants like vitamins and
carotenoids . 
Aim :The present study deals with the changes in serum ß-carotene in type 2 diabetes mellitus, as modulated by glycemic control and oxidative stress .
Subjects & methods : Multiple biochemical parameters were obtained from plasma of 57 patients with type 2 diabetes mellitus ( 25 males and 32 females ) , on oral hypoglycemic with
a disease duration of 1- 15 years and 37 healthy normal subject s of matching age and sex to serve as controls. The biochemical parameters measured in the present study i

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Publication Date
Sun Jul 31 2022
Journal Name
Iraqi Journal Of Science
The Key Role of Bone Function Markers in Patients with Type (II) Diabetes Mellitus

      Complications associated with diabetes are a consequence of acute disturbance in glucose metabolism in a human body. The most significant complication of diabetes is bone disorders which contributes to high levels of bone disability. This study included 118 diabetic patients, 56 males, 62 females, and 60 healthy non-diabetic controls, 30 males, 30 females. The patients and controls were age matched. Circulating levels of bone function markers (osteoprotegerin, vitamin D, PTH, total calcium and inorganic phosphorus) were determined in all subject groups. The data obtained from this study showed that the serum levels of osteoprotegerin had significantly increased in both diabetic male & female in both age ranges which were 4

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Publication Date
Sun Oct 01 2017
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Assessment of Preventive Foot Care Practices among Patients with Diabetes Mellitus Type II

Background: Diabetic foot problems are one of the most important complications of diabetes mellitus
which causing a worldwide high cost morbidity which could be due to poor self-practices.
Objectives: To assess the preventive food care practices among diabetic patients and to find out any
significant association of these practices with selected socio-demographical and diabetic related
characteristics.
Patients and Methods: A descriptive cross-sectional study was conducted in Baquba city from the
period of 20th Septembers, 2016 up to 20th March, 2017, by selecting a sample of (120) patients by
using a structured questionnaire, the questionnaire composed of three parts, the first part contains
information related to

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Publication Date
Sat Nov 10 2018
Journal Name
Iraqi National Journal Of Nursing Specialties
Effectiveness of Instructional Intervention on Medical and Health Information of Patients with Diabetes Mellitus Type II

Objective: The objectives of the present study were to evaluate the effectiveness of the instructional intervention
about medical and health knowledge of patients with diabetes mellitus type II.
Methodology: A Quasi- experimental study was carried out in National Center for Diabetes Mellitus/ Almustansria
University, started from 4th January 2012, to 1st April 2012. Non-probability (purposive sample) of (50) diabetes
mellitus type II, who visit National Center for Diabetes Mellitus/ Almustansria University. The study sample is
divided equally into (25) study and (25) control groups. The study group received the instructional intervention.
While the control not exposed to the instructional intervention. The data are coll

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Publication Date
Fri Jan 01 2021
Journal Name
Brazilian Dental Science
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Publication Date
Fri Jan 01 2021
Journal Name
Brazilian Dental Science
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Publication Date
Sun Jul 02 2017
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Serum leptin and 25 Hydroxyvitamin D levels in patients with type II diabetes mellitus

Background: Vitamin D and Leptin appears to play a range of roles in beta cell growth and insulin secretion and most importantly interaction with other hormonal mediators and regulators of energy and metabolism. Objective: The aim of this study was to measure serum leptin and vitamin D levels and to investigate their relationships with vitamin D and other clinical laboratory parameters in patients with type II diabetes. Subjects and Methods: Blood samples were taken from 80 patients with type II diabetes mellitus encountered during their attending the Internal Medicine clinic consultancy in Ramadi Teaching Hospital and the National Diabetes Center for Treatment and Research at Al-Mustansiriya University and 60 healthy subject. From Decem

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Publication Date
Sat Oct 01 2022
Journal Name
The Egyptian Journal Of Hospital Medicine
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