Preferred Language
Articles
/
CRjQbZQBVTCNdQwC6xed
DNMT3B Is an Oxygen-Sensitive De Novo Methylase in Human Mesenchymal Stem Cells
...Show More Authors

The application of physiological oxygen (physoxia) concentrations is becoming increasingly commonplace within a mammalian stem cell culture. Human mesenchymal stem cells (hMSCs) attract widespread interest for clinical application due to their unique immunomodulatory, multi-lineage potential, and regenerative capacities. Descriptions of the impact of physoxia on global DNA methylation patterns in hMSCs and the activity of enzymatic machinery responsible for its regulation remain limited. Human bone marrow-derived mesenchymal stem cells (BM-hMSCs, passage 1) isolated in reduced oxygen conditions displayed an upregulation of SOX2 in reduced oxygen conditions vs. air oxygen (21% O2, AO), while no change was noted for either OCT-4 or NANOG. DNA methylation marks 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) showed decreases in 2% O2 environment (workstation) (2% WKS). DNMT3B (DNA methyltransferase 3B) and TET1 (Ten-eleven translocation enzyme 1) displayed reduced transcription in physoxia. Consistent with transcriptional downregulation, we noted increased promoter methylation levels of DNMT3B in 2% WKS accompanied by reduced DNMT3B and TET1 protein expression. Finally, a decrease in HIF1A (Hypoxia-inducible factor 1A) gene expression in 2% WKS environment correlated with protein levels, while HIF2A was significantly higher in physoxia correlated with protein expression levels vs. AO. Together, these data have demonstrated, for the first time, that global 5mC, 5hmC, and DNMT3B are oxygen-sensitive in hMSCs. Further insights into the appropriate epigenetic regulation within hMSCs may enable increased safety and efficacy development within the therapeutic ambitions.

Scopus Clarivate Crossref
View Publication
Publication Date
Mon Jun 17 2019
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Transfer Factors as an Immunenhancer Against Adenovirus in Experimental Infection in Chicken
...Show More Authors

 A group of birds were passively immunized by a transfer factor extracted from lymphocytes sensitized to adenovirus and then they were challenged by the virulent virus (adenovirus isolated from hydropericardium infected birds). The results indicatede that the groups of birds that received the transfer factor or sensitized lymphocytes were protected from having any grossly pathological changes and having a high level of anti adenovirus antibodies.

View Publication Preview PDF
Publication Date
Mon Feb 21 2022
Journal Name
Frontiers In Immunology
The Ability of Resveratrol to Attenuate Ovalbumin-Mediated Allergic Asthma Is Associated With Changes in Microbiota Involving the Gut-Lung Axis, Enhanced Barrier Function and Decreased Inflammation in the Lungs
...Show More Authors

Asthma is a chronic respiratory disease highly prevalent worldwide. Recent studies have suggested a role for microbiome-associated gut–lung axis in asthma development. In the current study, we investigated if Resveratrol (RES), a plant-based polyphenol, can attenuate ovalbumin (OVA)-induced murine allergic asthma, and if so, the role of microbiome in the gut–lung axis in this process. We found that RES attenuated allergic asthma with significant improvements in pulmonary functions in OVA-exposed mice when tested using plethysmography for frequency (F), mean volume (MV), specific airway resistance (sRaw), and delay time(dT). RES treatment also suppressed inflammatory cytokines in the lungs. RES modulated lung microbiota and cause

... Show More
View Publication Preview PDF
Scopus (51)
Crossref (50)
Scopus Clarivate Crossref
Publication Date
Tue May 09 2017
Journal Name
Journal Of The College Of Languages (jcl)
Técnicas de la traducción del antropónimo del árabe al español: Fundamentos y أساليب ترجمة أسماء الأعلام من العربية الى الاسبانية: الأسس والتطبيقات
...Show More Authors

Publication Date
Mon Nov 13 2023
Journal Name
Published By Iraqi Translators Association
Congruencia estilística en la estructuración temática de la novela contemporánea árabe e hispánica Muhsin al-Ramli y Gabriel García Márquez Como muestra
...Show More Authors

AbstractoEl presente estudio tiene como objetivo realizar un análisis comparativo entre dos obras literarias destacadas: “El amor en los tiempos del cólera” del célebre escritor Gabriel García Márquez y la novela “Los jardines del presidente” del escritor iraquí Mohsen al-Ramli. Estas dos novelas, escritas en diferentes contextos culturales y geográficos, comparten una serie de elementos contextuales y narrativos que nos invitan a explorar sus similitudes y diferencias.Principalmente, ambas obras pertenecen al género del realismo y se sumergen en las circunstancias y experiencias de sus personajes en sociedades oscuras dominadas por la opresión, la guerra y las tradiciones impuestas. Los autores ofrecen una perspectiva crí

... Show More
View Publication
Publication Date
Fri Oct 30 2020
Journal Name
Journal Of Economics And Administrative Sciences
Development of human resources and their role in achieving artificial intelligence A survey of the views of a sample of workers in the cement plant
...Show More Authors

The research topic was chosen as a result of the importance of human resource in business organizations in general and the industrial process in particular. Without the human resource, business organizations cannot continue and achieve success and excellence, and the research problem has been diagnosed in the lack of sales of General Cement Company’s northern products, despite their distinctiveness, standing, and reputation in The market and its products with standard specifications, and through this problem, the following questions were raised:                                                    &nbs

... Show More
View Publication Preview PDF
Crossref
Publication Date
Sun Jan 01 2023
Journal Name
The Egyptian Journal Of Hospital Medicine
Changes in Interleukin-35 (IL-35), Anti-TSHR antibody and Human Insulin- like Growth Factor 1 Receptor (IGF1R) in Graves’ Disease Patients Treatedwith Radioactive Iodine
...Show More Authors

View Publication
Crossref
Publication Date
Wed May 17 2017
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
Evaluation Interleukin ─ 8 and High Sensitivity C - Reactive Protein in Sera of Control Group and Human Female Patients with Osteoarthritis Nodal in Iraqi's Patients
...Show More Authors

       The present study conducted on 30 female patients with osteoarthritis OA a attending Baghdad teaching hospital, in addition to 30 healthy females, all subjects were (35-65) year's old .Parameters were measured in the sera of patients group and healthy groups were interleukin -8 (IL-8) and high sensitivity C-reactive protein (hs-CRP).The results revealed a higher significant in all parameters of patients sera compared to healthy groups. Conclusion was obtained that IL-8 and hs- CRP were a markers or player inflammatory disease like osteoarthritis nodal  

 

View Publication Preview PDF
Publication Date
Mon Jan 01 2018
Journal Name
Journal Of The College Of Languages (jcl)
Estudio en la traducción del lenguaje de los horóscopos en la prensa del idioma español al árabe A study in translating the language of the horoscope in the press from Spanish into Arabic
...Show More Authors

Resumen:

        El horóscopo que es una predicción deducida de la posición de los astros del sistema solar y de los signos de Zodiaco, intenta no sólo predecir el futuro, sino también influir en el comportamiento del lector, orientándolo para que actúe adecuadamente y la invitación a actuar ante ese futuro que se aconseja mediante imperativos, perífrasis y otros recursos lingüísticos. Los horóscopos se caracterizan por su gran popularidad que existen en periódico o revista en columnas enteras dedicadas al tema, en donde se detallan la influencia que tendrá el día o el mes de cada uno de los signos correspondientes al zodíaco, siempre teniendo en cuenta la posici

... Show More
View Publication Preview PDF
Publication Date
Tue Oct 01 2019
Journal Name
2019 International Conference On Electrical Engineering And Computer Science (icecos)
An Evolutionary Algorithm for Community Detection Using an Improved Mutation Operator
...Show More Authors

View Publication
Scopus (5)
Crossref (2)
Scopus Clarivate Crossref
Publication Date
Wed Jul 20 2022
Journal Name
Ibn Al-haitham Journal For Pure And Applied Sciences
An Application Model for Linear Programming with an Evolutionary Ranking Function
...Show More Authors

One of the most important methodologies in operations research (OR) is the linear programming problem (LPP). Many real-world problems can be turned into linear programming models (LPM), making this model an essential tool for today's financial, hotel, and industrial applications, among others. Fuzzy linear programming (FLP) issues are important in fuzzy modeling because they can express uncertainty in the real world. There are several ways to tackle fuzzy linear programming problems now available. An efficient method for FLP has been proposed in this research to find the best answer. This method is simple in structure and is based on crisp linear programming. To solve the fuzzy linear programming problem (FLPP), a new ranking function (R

... Show More
View Publication Preview PDF
Crossref (1)
Crossref