A simple reverse-phase high performance liquid chromatographic method for the simultaneous analysis (separation and quantification) of furosemide (FURO), carbamazepine (CARB), diazepam (DIAZ) and carvedilol (CARV) has been developed and validated. The method was carried out on a NUCLEODUR® 100-5 C18ec column (250 x 4.6 mm, i. d.5μm), with a mobile phase comprising of acetonitrile: deionized water (50: 50 v/v, pH adjusted to 3.6 ±0.05 with acetic acid) at a flow rate 1.5 mL.min-1 and the quantification was achieved at 226 nm. The retention times of FURO, CARB, DIAZ and CARV were found to be 1.90 min, 2.79 min, 5.39 min and 9.56 min respectively. The method was validated in terms of linearity, accuracy, precision, limit of detection and limit of quantitation. The developed method was successfully applied for the estimation of furosemide, carbamazepine, diazepam and carvedilol in bulk and in pharmaceutical dosage forms.
Ebastine (EBS) is a poorly water-soluble antihistaminic drug; it belongs to the class II group according to the biopharmaceutical classification system (BCS). The aim of the present work was to enhance the solubility, dissolution rate and micromeritic properties of the drug, by formulating it as spherical crystal agglomerates by Quasi Emulsion Solvent Diffusion (QESD) method.
Spherical crystal agglomerates (SCAs) were prepared in presence of three solvents dichloromethane (DCM), water and chloroform as a good solvent, poor solvent and bridging solvent respectively. Agglomeration of EBS involved the use of some hydrophilic polymers like polyethylene glycol 4000 (PEG 4000), polyvinyl pyrrolidine K30 (PVP K30), D-?-tocopheryl
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Use of lower squares and restricted boxes
In the estimation of the first-order self-regression parameter
AR (1) (simulation study)
In this paper we proposed a new method for selecting a smoothing parameter in kernel estimator to estimate a nonparametric regression function in the presence of missing values. The proposed method is based on work on the golden ratio and Surah AL-E-Imran in the Qur'an. Simulation experiments were conducted to study a small sample behavior. The results proved the superiority the proposed on the competition method for selecting smoothing parameter.
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Terrestrial laser scanners (TLSs) are 3D imaging systems that provide the most powerful 3D representation and practical solutions for various applications. Hence this is due to effective range measurements, 3D point cloud reliability, and rapid acquisition performance. Stonex X300 TOF scanner delivered better certainty in far-range than in close-range measurements due to the high noise level inherent within the data delivered from Time of Flight (TOF) scanning sensors. However, if these errors are manipulated properly using a valid calibration model, more accurate products can be obtained even from very close-range measurements. Therefore, to fill this gap, this research presents a user-oriented target-based calibration routine to
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An Alternating Directions Implicit method is presented to solve the homogeneous heat diffusion equation when the governing equation is a bi-harmonic equation (X) based on Alternative Direction Implicit (ADI). Numerical results are compared with other results obtained by other numerical (explicit and implicit) methods. We apply these methods it two examples (X): the first one, we apply explicit when the temperature .
In this paper, we present an approximate method for solving integro-differential equations of multi-fractional order by using the variational iteration method.
First, we derive the variational iteration formula related to the considered problem, then prove its convergence to the exact solution. Also we give some illustrative examples of linear and nonlinear equations.
The main purpose of the work is to apply a new method, so-called LTAM, which couples the Tamimi and Ansari iterative method (TAM) with the Laplace transform (LT). This method involves solving a problem of non-fatal disease spread in a society that is assumed to have a fixed size during the epidemic period. We apply the method to give an approximate analytic solution to the nonlinear system of the intended model. Moreover, the absolute error resulting from the numerical solutions and the ten iterations of LTAM approximations of the epidemic model, along with the maximum error remainder, were calculated by using MATHEMATICA® 11.3 program to illustrate the effectiveness of the method.
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in this paper the collocation method will be solve ordinary differential equations of retarted arguments also some examples are presented in order to illustrate this approach