Background: The global threat of COVID-19 outbreak and on the 11 March 2020, WHO acknowledged that the virus would likely spread to all countries across the globe and declared the coronavirus outbreak a pandemic which is the fifth pandemic since 20 century and this has brought human lives to a sudden and complete lockdown and the confirmed cases of this disease and deaths continue to rise in spite of people around the world are taking important actions to mitigate and decrease transmission and save lives. Objectives: To assess the effect of exercise and physical activity on the immunity against COVID-19. Methods: Collected electronic databases including (Medline, EMBASE, Google Scholar, PubMed and Web of Science) were searched without language restrictions to recognize all studies and reports on sports and physical activity related to COVID-19 due to alterations in the immune parameters. Results: Physical activity including sports and exercise induces obvious immune responses in many elements of the immune system whether transient or permanent that had a role in defense reaction against infection like COVID-19. This mediated through the nervous and endocrine systems that play a key role in determining exercise induced immune changes. Massive impact sports have on every aspect of our lives. Conclusions: Mild to moderate sports leads to stimulate an immune system that can subside COVID-19 infection and keep each other safe until this outbreak subsides and life is back to being greater than ever.