It is becoming a public health issue to predict which expectant women will develop gestational diabetes mellitus (GDM). The goal of this case control research is to investigate the role of maternal oxidative stress levels in the first, second, and third trimesters, as well as other factors, in the development of gestational diabetes mellitus (GDM).
Methods
Between October and December 2021, 142 women participated in this research. The 101 GDM patients were split into three groups based on their gestation (T1, T2, and T3), and 41 healthy pregnant women were chosen as the comparison group. TAS and TOS levels of oxidative stress and XO were calculated using a Spectrophotometer for colorimetric techniques; fasting and random sugar levels, as well as HbA1c, were evaluated.
Results
Afamin levels were significantly greater in women with GDM in all trimester (T1=51.63 ± 3.86, T2=57.39 ± 3.17, T3=64.22 ± 3.67 ng/mL) in comparison with control (45.93 ± 2.26) with statistical significance (P ≤ 0.01). Afamin levels were higher significantly in T3>T2>T1.The levels of oxidative stress were higher significantly in women with GDM in all trimester (T1=73.79 ± 18.43, T2=81.28 ± 18.06, T3=96.70 ± 20.69) in comparison with control (37.28 ± 18.95) with statistical significance (P = 0.000). Oxidative stress levels were higher significantly in T3>T2>T1. The measured TOS and XO levels were  higher in all GDM groups compared with control (p=0.000) and high significant between patient groups (T3>T2>T1), while high significant of TAS in GDM than control but (T3
The present study was designed to find the relation between oxidative stress and
pregnancy. The study used one hundred twenty volunteers (ninety pregnant women
and thirty non-pregnant women). Then pregnant women were divided to three
subgroups according to trimester (first trimester, second trimester and third
trimester). then, some oxidative stress factors (MDA, GSH, catalase and TAC) were
measurement. Biochemical tests showed significant (P<0.05) increase in
malonedialdehyied (MDA) and significant (P<0.05) decrease in Glutathione (GSH),
Catalase (CAT) and total antioxidant capacity (TAC) in pregnant women compared
with non-pregnant women group. It was concluded from this study that the
pregnancy led to
protein oxidation through oxidative stress, which represents the overall status of the protein in the cell/tissue. Due to their increased levels of AOPPs were reported during T2DM. The aim of this study was to assess AOPP level in T2DM subjects with foot ulcer (DFU) and explore its correlation with infection. Type 2 diabetic patients (n=108) and healthy subjects (n=25) were enrolled in this study. The T2DM group was subdivided to diabetic patients without complications (n=25) and eighty-three (83) of them have diabetic foot. They were sub- grouped into two groups according to presence Osteomyelitis and abscess, and in reliance on medical analysis of WBC count and CRP. Group of diabetic without superficial or deep ulcer and no osteomyelitis
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Background: Oxidative stress may contribute to the etiology of hypertension in humans. Oxidative stress is an imbalance between reactive oxygen species (ROS) and antioxidant defense mechanisms, causing damage to biological macromolecules and dysregulation of normal metabolism and physiology. Amlodipine as an antihypertensive agent is a long-acting calcium channel blocker that dilates blood vessels and improves blood flow. The aim of this study was to assess the oxidative stress in hypertensive patients on Amlodipine treatment through the assessment of salivary Malondialdehyde (MDA) and superoxide dismutase (SOD) as a marker of oxidative stress.
Mat
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(1)
Back ground:-Rheumatoid arthritis (RA) is a systemic disease characterized by progressive, erosive and chronic poly arthritis, where cellular proliferation of the synoviocytes and neo-angiogenesis leads to formation of pannus which destroys the articular cartilage and the bone .
Objective :-to evaluate theOxidative Stress index( OSI )by measuring malondialdehide( MDA) and Total Antioxidant Capacity( TAC) in serum of RA patients in addition to uric acid and albumin and to investigate the alteration in these parameters compared to healthy individuals.
Patients and Methods :- twenty five patients with rheumatoid arithritis and twenty five apparen
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(1)
Reactive oxygen species (ROS) are produced as a result of biochemical processes that are not in balance with the body's antioxidant defense mechanism. This metabolic dysfunction is referred to the oxidative stress (OS). Metabolic dysfunction-associated diseases are affected by changes in the redox balance. It is now widely recognized that oxidative stress significantly affects diabetes mellitus (DM), particularly type 2 diabetes. The biochemical changes associated with DM could disturb the oxidative milieu, leading to several microvascular complications in diabetic patients. Thus, DM is a perfect disease to explore the harmful consequences of oxidative stress and how to treat it. Oxidative stress triggered by hyperglycemia is
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(2)
This study is conducted to evaluate the therapeutic and antioxidant effect of lemon juice on some hematological and biochemical parameters. Thirty female mice used in this study were exposed to oxidative stress through giving them hydrogen peroxide in drinking water for 30 days. Animals randomly distributed over 3 groups, each group contained 10 animals and treated as follows: T1 control group (drinking distilled water only), T2 (0.75% hydrogen peroxide in drinking water) and T3 (0.75% hydrogen peroxide in drinking water with daily drenching with 1 mL lemon juice). At the end of the experiment, blood samples were collected from animals for evaluating the following hematological and biochemical parameters: Haemoglobin concentration (Hb),
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(6)
Background: In the last years, Endometriosis affects up to 10 percent of reproductive aged Iraqi women. Little is known about the etiology of endometriosis in Iraqi women.
Objectives: The aim of this study is to investigate the hormonal changes, antioxidant status, Coenzyme Q10 and oxidative stress in women patients with endometriosis.
Patients and methods: 30 endometriotic women mean aged (31.16±5.61 year ) who were undergoing laparoscopy to participate in this study, and (n=30) healthy women volunteers mean aged (31.96±5.42 year) as control group.
Results: The results in this study revealed a highly significant increased (P<0.01) in estradiol (E2), uric acid (UA) and oxidative stress (MDA). The results of the Coenzyme Q10
(1)
Interleukin -33 (IL)-33 is among IL-1 cytokine superfamily , which shows promise as a biomarker predictive of mortality in diabetic and several cardiovascular disorders in vivo study.The objective of this study is to investigate the differences in the levels of IL-33 between healthy controls and patients with type 2 diabetes and diabetic cardiomyopathy and to investigate the correlation of IL-33 with HbA1C (biomarkers of type 2 diabetes), hs-CRP and oxidant –antioxidant status. One hundred and fifty individuals (age 40-55) were enrolled in this study which was divided into three groups as follows: G1:50 healthy control,G2: 50 subjects with type 2 diabetes mellitus,G3: 50 patients with dia
... Show MoreOne of the most prevalent illnesses in developing countries is myocardial infarction (MI), which develops when the heart's blood supply is suddenly interrupted and causes tissue damage. It is connected to several metabolic risk factors, including diabetes, hypertension, and obesity. The objective of this study was to assess how oxidative stress (OS) contributed to the pathophysiology of MI and T2DM. The current study examined 152 male samples, including 52 MI patients without T2DM (G1), 50 MI patients with T2DM (G2), and 50 seemingly healthy men as controls (C). The levels of fasting blood sugar (FBS), C-reactive protein (CRP), total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), malondialdeh
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The study concentrated on measuring the lipid peroxidation marker malon di aldehyde (MDA) in sera of thirty five patients with minor Thalassemia (Tm), thirty five with major Thalassemia (TM) and thirty five healthy control, their age ranged from (17-30) years. Erythrocytes enzymes (Glutathione -S - transferase (GST )and Catalase) were assayed . The results showed a significant elevation in (MDA) in sera of both patient groups compared to control.
An increase in the activity of catalase and GST in erythrocytes of
minor Thalassemic patients compared to control was found to be significant. Also, a high significant increase in the
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