—Breast cancer (BC) remains a health challenge in Iraq, with patients presenting at younger ages and advanced stages. While gene fusions, particularly ETV6-NTRK3, are established oncogenic drivers in subtypes like secretory breast carcinoma (SBC), their prevalence within the Iraqi population remains unexplored. This study aimed to detect the ETV6-NTRK3 gene fusion in Iraqi patients with BC to define its diagnostic specificity and clinicopathological correlates. Formalin-fixed paraffin-embedded tissue blocks from 60 women (aged 20–50 years) diagnosed with BC were collected. Samples were classified into three equal groups: SBC, Invasive Carcinoma of no special type, and invasive lobular carcinoma (n = 20 for each). The ETV6-NTRK3 fusion was detected using fluorescence in situ hybridization with a dual-color break-apart probe. The ETV6-NTRK3 fusion was detected exclusively in the SBC, with a prevalence of 100% (19/19 successfully scored cases), while it was absent in all scored cases of other groups, yielding a positive predictive value of 100% and a negative predictive value of 100%. Fusion-positive SBC tumors were associated with clinicopathological features: they were exclusively low to intermediate histological grade (Grades I-II) and predominantly presented at early pathological stages (Stage I-II: 84.2%). The fusion-positive cases were 93 times more likely to present with an early stage of disease compared with fusion-negative cases (odds ratio: 93.33; 95% confidence interval: 16.15–539.19). In conclusion, the ETV6-NTRK3 fusion may be a definitive molecular hallmark of SBC in Iraqi patients, and could demonstrate perfect diagnostic specificity and association with a less aggressive phenotype.
An abstract is a brief summary of a research article, thesis, Schiff base ligand (L) was prepared by the reaction of 4-aminantipyrine with o-phenylenediamine, the prepared ligand characterized by Micro elemental Analysis, FT. IR, UV-Vis, and 1H,13C-NMR spectroscopy.complexes of Mn(II), Co(II), Ni(II), Cu(II) and Hg(II) with Schiff base and 1,10-phenanthroline (Phen) have been investigated in aqueous ethanol with (1:1:1) (M:L:Phen). The prepared complexes were characterized using flame atomic absorption, (C. H. N) Analysis, FT. IR and UV-Vis spectroscopic methods as well as magnetic susceptibility and conductivity measurements. From the obtained data the octahedral structure was suggested for all complexes. The biological screening effects o
... Show MoreRehabilitation robots are widely recognized as vital for restoring motor function in patients with lower-limb impairments. A Modified Fractional-Order Proportional-Integral-Derivative (MFOPID) controller is proposed to improve trajectory tracking of a 2-DoF Lower Limb Rehabilitation Exoskeleton Robot (LLRER). The classical FOPID is augmented with a modified control formulation by which steady-state error is reduced and the transient response is sharpened. Controller gains and fractional orders were tuned offline using a hybrid metaheuristic Improved Elk Herd Optimization hybridized with Grey Wolf and Multi-Verse Optimization algorithms (IElk-GM) so that exploration and exploitation are balanced. Superiority over the classical FOPID
... Show MoreNew mixed ligand complexes of New Schiff base 4,4'- ((naphthalen-1-ylimino) methylene) dibenzene-1,3-diol and 8-hydroxy quinoline: Synthesis, Spectral Characterization, Thermal studies and Biological Activities
The paper tackles two topics. The first is about the term "Ремейк" which is very common in contemporary Russian literature; it has counterparts such as " Обработка" and " Переделка", where these two may indicate any of the following meanings (remake, reformulate, rewrite, treatment, modification, change). It has been shown that this term does not have a stable definition. Also, the role of this term in literary studies has been mentioned along with how it has come to its peak of use in post-modern literature.
The second is that I have taken a sample of well-known works in Russian literature " On the Eve, On the Eve " by the contemporary Russian writer YevgueniBobov, and shown the effort of the writer
... Show MoreThe new 4-[(7-chloro-2,1,3-benzoxadiazole)azo]-4,5-diphenyl imidazole (L) have been synthesized and characterized by micro elemental and thermal analyses as well as 1H.NMR, FT-IR, and UV-Vis spectroscopic techniques. (L) acts as a ligand coordinating with some metal ionsV(IV), Fe(III), Co(II), Ni(II), Cu(II), and Zn(II). Structures of the new compounds were characterized by elemental and thermal analyses as well as FT-IR and UV-Vis Spectra. The magnetic properties and electrical conductivities of metal complexes were also determined. Study of the nature of the complexes formed in ethanol following the mole ratio method.. The work also include a theoretical treatment of the formed complexes in the gas phase, this was done using the (hyperch
... Show MoreEnticed by the present scenario of infectious diseases, four new Co(II), Ni(II), Cu(II), and Cd(II) complexes of Schiff base ligand were synthesized from 6,6′-((1E-1′E)(phenazine-2,3-dielbis(azanylidene)-bis-(methanylidene)-bis-(3-(diethylamino)phenol)) (