CD40 Gene Variants and Disease Susceptibility: A Comprehensive Review of Associations with Immune-Mediated Inflammatory Diseases, Cancer, and Infectious Diseases

Aisha Muthanna Shanshal; Samer Imad Mohammed; Bassam Francis  Matti

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Publication Date

Sun Apr 27 2025

Journal Name

Al-rafidain Journal Of Medical Sciences ( Issn 2789-3219 )

Volume

8

Issue Number

2

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CD40 Gene Variants and Disease Susceptibility: A Comprehensive Review of Associations with Immune-Mediated Inflammatory Diseases, Cancer, and Infectious Diseases

CD40

Case control

Immune disease

Polymorphism

Aisha Muthanna Shanshal

Samer Imad Mohammed

Bassam Francis Matti

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CD40 is a type 1 transmembrane protein composed of 277 amino acids, and it belongs to the tumor necrosis factor receptor (TNFR) superfamily. It is expressed in a variety of cell types, including normal B cells, macrophages, dendritic cells, and endothelial cells, as a costimulatory molecule. This study aims to summarize the CD40 polymorphism effect and its susceptibility to immune-related disorders. The CD40 gene polymorphisms showed a significant association with different immune-related disorders and act as a risk factor for increased susceptibility to these diseases.

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Publication Date

Tue Feb 27 2018

Journal Name

Pharmaceutics

Ocular Drug Delivery Barriers—Role of Nanocarriers in the Treatment of Anterior Segment Ocular Diseases

Bachu R.D.

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Ocular drug delivery is challenging due to the presence of anatomical and physiological barriers. These barriers can affect drug entry into the eye following multiple routes of administration (e.g., topical, systemic, and injectable). Topical administration in the form of eye drops is preferred for treating anterior segment diseases, as it is convenient and provides local delivery of drugs. Major concerns with topical delivery include poor drug absorption and low bioavailability. To improve the bioavailability of topically administered drugs, novel drug delivery systems are being investigated. Nanocarrier delivery systems demonstrate enhanced drug permeation and prolonged drug release. This review provides an overview of ocular barr

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Publication Date

Wed Dec 30 2015

Journal Name

Al-kindy College Medical Journal

Estimation Of Left Ventricular Ejection Fraction Using Mitral Annular Displacement Derived By Speckle Tracking Echocardiography In Patients With Different Heart Diseases

ventricle

ejection fraction

echocardiography

.Mohammed Ameen

.Amal N.

Ghazi F.

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Background: Speckle tracking echocardiography (STE)-derived mitral annular displacement (MAD) utilizes the speckle tracking technique to measure strain vectors, which provides accurate estimates of left ventricular ejection fraction (LVEF).Objectives: To validate the accuracy of mitral annular displacement (MAD), assessed by Speckle Tracking Echocardiography (STE), as a surrogate for determination of left ventricular systolic function in comparison to 2-Dimensions Simpson method in patients with different heart diseases.Methods : This cross-sectional study included patients who referred to outpatient department of Ibn Albitar Center for Cardiac Surgery, Baghdad, Iraq, between October 2012 and April 2013. STE continuously tracked annular

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Mon Feb 01 2021

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Meta Gene

Association analysis of FTO gene polymorphisms rs9939609 and obesity risk among the adults: A systematic review and meta-analysis

Alaa

Tatiana

Ali

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Pakistan Journal Of Medical & Health Sciences

Roles of Il-36 in the Pathogenesis of Inflammatory Bowel Disease in a Sample of Iraqi Patients

Hanan Y.

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Thu Mar 19 2015

Journal Name

Spie Proceedings

Role of testosterone in resistance to development of stress-related vascular diseases in male and female organisms: models of hypertension and ulcer bleeding

O.

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E.

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2nd International Conference On Mathematical Techniques And Applications: Icmta2021

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William R.

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Inorganic Chemistry Communications

A comprehensive review highlights the photocatalytic heterojunctions and their superiority in the photo-destruction of organic pollutants in industrial wastewater

Aya A

Abeer I.

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Publication Date

Sun Dec 01 2019

Journal Name

Journal Of Coloproctology

Rectal cancer and chemoradiation in Iraq: systematic review and meta-analysis

Manwar

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Abstract Background Rectal cancer is one of the most common malignant tumors of gastrointestinal tract. Combining chemotherapy with radiotherapy has a sound effect on its management. Objectives Assessment the patterns of characterizations of rectal cancer. Evaluation of the efficacy, and long-term survival of pre-/ postoperative chemoradiation. Collecting all eligible evidence articles and summarize the results. Methods By this systematic review and meta-analysis study, we include data of chemoradiation of rectal cancer articles from 2015 until 2019. The research was carried out at Baghdad Medical City oncology centers. Accordance with the ... Show More

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Publication Date

Tue Mar 01 2022

Journal Name

Iraqi Journal Of Agricultural Sciences

CORRELATION OF TMPRSS2-ERG GENE FUSION STATUS WITH CLINICOPATHOLOGICAL CHARACTERISTICS IN PROSTATE CANCER OF IRAQI PATIENTS

The aim of this study was to establish the existence and interaction of TMPRSS2 – ERG gene fusion status with clinicopathological features of prostate cancer patients. This research consisted of 123 embedded formalin-fixed tissues obtained from the prostate tumor patients. The above gene fusion is detected through the technique of fluorescent in situ hybridization (FISH) by means of a triple color probe. Seven samples have not been scored due to technical difficulties and 46 patients have fusion (39.6%)

while the remaining (70) have not been seen with fusion. Of the 46 fusion-positive

17 (36%) were caused by ERG-translocation

of the other 29 (63%) were caused by the interstitial segment deletion between the two genes due to their sequential position. In order to find a substantial correlation between 116 patients (fusion took place in 46 and non-fusion in 70) with clinicopathological features

the following findings were calculated: Our findings recorded non-significant correlation at age

BMI and tumor size at which (P-value >0.05).While results showed significant association with: pathological T stage (P value = 0.011)

Gleason score (P value = 0.002)

perineural invasion (P value = 0.047) and PSA (P value = 0.033). The clinicopathological features which had a considerable correlation with fusion status are very important as they aid the doctors in prognosis and treatment of such tumor.

Ammar

Maha

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