In medical practice, nonsteroidal anti-inflammatory drugs (NSAIDs) are often used to treat osteoarthritis and rheumatoid arthritis. Ibuprofen is a well-known NSAID, analgesic, and antipyretic medication. This chemical is an active ingredient of several oral medications that are offered in tablet, gel pellet, and syrup forms and has higher efficacy, tolerance, and side effect rates than other compounds, including pyrazolone derivatives. We present a unique plasma-assisted desorption/ionization mass spectrometry (PADI-MS) approach for improving pharmaceutically important solids using an ibuprofen tablet as a model solid sample. The goal of the study is to create an innovative mass spectrometric method that could be used for quick and accurate analysis in the development of pharmaceutically relevant compounds. Sniffer tubes were used to route sample ions into a single quadrupole MS, with each acquisition lasting for 1 minute. Without any prior preparation, samples of ibuprofen tablets were directly exposed to PADI plasma for one minute at an atmosphere pressure. The approach is rapid, easy to use, and needs little to no sample preparation. In this study, the settings were improved by optimization of several parameters, such as plasma power, plasma-to-sample distance, and inner/outer flows of helium carrier gas, which were found to be 8 W, 2 mm, and 284 mL/min, respectively. The PADI-MS method provides a real-time information about structural features on the compounds. Ibuprofen tablets were used as a paradigm for pharmaceutically significant materials and direct PADI-MS analysis without a preliminary sample -treatment appeared to be successful: according to PADI-MS data a medication can be examined after one minute of plasma exposure.
In this paper we proposes the philosophy of the Darwinian selection as synthesis method called Genetic algorithm ( GA ), and include new merit function with simple form then its uses in other works for designing one of the kinds of multilayer optical filters called high reflection mirror. Here we intend to investigate solutions for many practical problems. This work appears designed high reflection mirror that have good performance with reduction the number of layers, which can enable one to controlling the errors effect of the thickness layers on the final product, where in this work we can yield such a solution in a very shorter time by controlling the length of the chromosome and optimal genetic operators . Res
... Show More
In this paper, we proposed a modified Hestenes-Stiefel (HS) conjugate
gradient method. This achieves a high order accuracy in approximating the second
order curvature information of the objective function by utilizing the modified
secant condition which is proposed by Babaie-Kafaki [1], also we derive a nonquadratic
conjugate gradient model. The important property of the suggestion
method that is satisfy the descent property and global convergence independent of
the accuracy of the line search. In addition, we prove the global convergence under
some suitable conditions, and we reported the numerical results under these
conditions.
(2)
(1)
Data security is a significant requirement in our time. As a result of the rapid development of unsecured computer networks, the personal data should be protected from unauthorized persons and as a result of exposure AES algorithm is subjected to theoretical attacks such as linear attacks, differential attacks, and practical attacks such as brute force attack these types of attacks are mainly directed at the S-BOX and since the S-BOX table in the algorithm is static and no dynamic so this is a major weakness for the S-BOX table, the algorithm should be improved to be impervious to future dialects that attempt to analyse and break the algorithm in order to remove these weakness points, Will be generated dynamic substitution box (S-B
... Show MoreTwo simple and sensitive spectrophotometric methods are proposed for the determination of amitriptyline in its pure form and in tablets. The first method is based on the formation of charge- transfer complex between amitriptyline as n-donor and tetracyano-ethylene (TCNE) as πacceptor. The product exhibit absorbance maximum at 470 nm in acetonitrile solvent (pH =9.0 ) . In the second method the absorbance of the ion- pair complex, which is formed between the soughted drug and bromocresol green (BCG), was measured at 415 nm at ( pH=3.5) . In addition to classical univariate optimization, modified simplex method (MSM) was applied in the optimization of the variable affecting the color producing reaction by a geometric simple
... Show More
(1)
(4)
(2)
The aim of this research is to calculate mass transfer coefficient, kd, during cathodic protection of low carbon steel in neutral seawater (3.5% W/V NaCl in distilled water with pH = 7). Two types of cathodic protection were used:
First: Sacrificial anode cathodic protection (SACP) were a pipeline of steel carrying seawater using zinc as a sacrificial anode and with variable temperatures ranged (0 – 45oC) and volumetric flow rate ranged (5 – 900 lit/hr). It was found that the kd increases with increasing temperature and volumetric flow rate of seawater, where kd ranged (0.24×10-6 – 41.6×10-6 m/s).
Second: Impressed current cathodic pr
... Show MoreExciton model describes the excitation of particles in pre-equilibrium region of nuclear reaction by exciton. In pre-equilibrium region there is a small probability for occurring emission and the number of excitons be the probability of the emission of it possible more is called most probable exciton number MPEN. In this paper the MPEN formula was derived for protons and neutrons separately and so MPEN formula derived with taking into account the non equidistant spacing between the energy states. The MPEN was studied with the mass number where it is noticed the MPEN increases with increasing the mass number. Also, MPEN studied for different isotopes of Al, the MPEN increases with increasing mass number of isotopes. MPEN for neutron is co
... Show MoreIn this work, the electrostatic probe was utilized to estimate the density of electrons for plasma generated around reentry vehicles that have a geometrically blunt nose at high-altitude. The thermocouple uses to measured electron temperature, which is equal to the temperature of the gas, on board the MAC spacecraft. In the spacecraft backflow field, electrostatic probe measurements were taken at five separate regions 1 to 5 cm from the body of the spacecraft. Over an altitude range of 90 to 50 km with an electron density of 108 to 1012 1/cm3, respectively. The measured electron temperature ranged from 0.05 to 0.9 electron volts and the maximum re-entry velocity of the spacecraft was about 7048 m
... Show More