Mefenamic acid belongs to non-steroidal anti-inflammatory drugs that are used widely for the treatment of analgesia. Our aim from this study is to establish a new assay for the quantitative determination of mefenamic acid (MFA) in the pharmaceutical sample by two sensitive and rapid flow injection-fluorometric methods. A homemade fluorometer was used in fluorescence measurements, which using solid-state laser diode 405 and 532 nm as a source, combined with a continuous flow injection technique. The first method depends on the effect of MFA on calcein blue (CLB) fluorescence at 405 nm. Another method is a study of rhodamine-6G (Rh-6G) fluorescence after adding MFA, and recording at 532 nm. Optimum parameters as fluorescent dye concentration, basic medium, flow rate, sample volume, purge time, and delay coil have been investigated. The dynamic range of MFA was 0.2 to 2 mmol.L-1; 0.5 to 2.3 mmol.L-1 with linearity percentage (% r2) 98.92 and 99.83%, for Rh-6G and CLB, respectively. Limit of detection at a minimum concentration in calibration curve 189.34 and 199.89 ng/sample, for Rh-6G and CLB, respectively. The comparison of developed methods with the classical method (UV-vis spectrophotometry) was achieved. The proposed methods were successfully applied for the determination of MFA in the pharmaceutical samples and can be used as an alternative method.
Simultaneous determination of Furosemide, Carbamazepine, Diazepam, and Carvedilol in bulk and pharmaceutical formulation using the partial least squares regression (PLS-1 and PLS-2) is described in this study. The two methods were successfully applied to estimate the four drugs in their quaternary mixture using UV spectral data of 84synthetic mixtures in the range of 200-350nm with the intervals Δλ=0.5nm. The linear concentration range were 1-20 μg.mL-1 for all, with correlation coefficient (R2) and root mean squares error for the calibration (RMSE) for FURO, CARB, DIAZ, and CARV were 0.9996, 0.9998, 0.9997, 0.9997, and 0.1128, 0.1292, 0.1868,0.1562 respectively for PLS-1, and for PLS-2 were 0.9995, 0.9999, 0.9997, 0.9998, and 0.1127, 0.
... Show MoreThis study was carried out on 10 adult females of albino mice , aged 8 – 10 weeks and 24 – 27 gm weight . In addition to 10 males were used for mating in order to determine the effect of injection of bromocriptine on the early stages of pregnancy and this was observed by measuring the weights of some component of female reproduction . The animals were divided into groups
... Show MoreSmishing is a cybercriminal attack targeting mobile Short Message Service (SMS) devices that contains a malicious link, phone number, or email. The attacker intends to use this message to steal the victim's sensitive information, such as passwords, bank account details, and credit cards. One method of combating smishing is to raise awareness and educate users about the various tactics used by SMS phishers. But even so, this method has been criticized for becoming inefficient because smishing tactics are continually evolving. A more promising anti-smishing method is to use machine learning. This paper introduces a number of machine learning algorithms that can be used for detecting smishing. Furthermore, the differences and simil
... Show MoreWe use the idea of the grill. This study generalized a new sort of linked space like -connected and -hyperconnected and investigated its features, as well as the relationship between it and previously described notions. It also developed new sorts of functions, such as hyperconnected space, and identified their relationship by offering numerous instances and attributes that belong to this set. This set will serve as a starting point for further research into the set many future possibilities. We also use some theorems and observations previously studied and related to the grill and the semi-open to obtain results in this research. We applied the concept of connected to them and obtained results related to connected. The sources related t
... Show MoreTo maintain river flows necessary to meet social and ecological objectives, instream environmental flows are frequently used as a strategy. The capability of three alternative historical flow approaches to protect against low flows is shown in this study using gage stations in the Shatt Al-Hillah River in Iraq. The extension of the Shatt al-Hillah River is the focus of this research discussion on environmental flow assessment. The available data on discharge in this research were adopted for ten years from 2012-2021. Different flow methods were adopted to establish a minimum environmental flow in the Shatt Al-Hillah River. Three hydrological-based approaches: Tennant, modified Tennant, and low-flow metrics like 7Q10, wer
... Show MoreBackground: Anterior disc displacement with reduction (ADDWR) is the most common form of the internal derangement (ID) of temporomandibular joint (TMJ). It is a painful progressive dysfunction and clinically characterized by reciprocal clicking due to shift in the disc anteriorly in relation to the condyle and fossa during mandible elevation. Minimally invasive therapy such as intra-articular injection of platelet-rich plasma (PRP) has been used. PRP is a natural autologous product with a high platelet concentration obtained by centrifugation process to enhance tissue healing through several growth factors (GFs), which are released after endogenous activation. The aim of this study is to assess this technique which is increasingly used toda
... Show MoreThis study was conducted to detect the concentration of lead and cadmium in baby foods, (18) samples were examined, which are the most available from various local markets in the city of Baghdad (at a rate of (9) samples of baby food consisting of cereals and (9) samples of baby foods consisting of vegetables). All samples were examined using an atomic flame absorptiometry (AAS-7000), all results showed the presence of lead and cadmium and the highest concentration value of lead in baby foods consisting of cereals (1.0986) and cadmium in baby foods consisting of vegetables (0.0015) ppm. Lead exceeded 100% limitations and cadmium did not exceed that. The results reported on the risks of contamination, as the mean daily intake (g/kg/d) for
... Show MoreFluconazole was used to test the susceptibility of Candida albicans isolated from different clinical samples, and to detect mutations in ERG11 gene, and their relationship to fluconazole resistance. Forty-eight isolates of Candida albicans were tested for susceptibility using the disc diffusion method (M-44). ERG11 genes of six isolates were amplified (four resistant, two susceptible) and sequenced. The sequenced genes were analyzed to detect the mutations. Out of 48 isolates of Candida albicans, 4 (8%) were resistant to fluconazole. Sixteen-point mutations were detected included 13 silent mutations, and three missense mutations. The mutations of A945C (E266D) and G1609A (V488I) were found only in susceptible Candida albicans isolates, whil
... Show MoreHydrochemical study of groundwater has carried out for the Al-Khassa Sub-Basin during the October 2020 and May 2021 seasons for estimating the impacts of seasonal variation and human activity on water quality and using the isotope to determine the main source of recharge. It was found that Biological Oxygen Demand (BOD), Chemical Oxygen Demand (COD), and Dissolved Oxygen (DO) were out of the standard indicating that the groundwater environment was reduced and difficult to recover from pollution. Physical and chemical properties that were high (Total Dissolved Solid (TDS), Total Suspended Solid (TSS), Electrical conductivity (EC), Total Hydrocarbon (THC)). Partial pollution by nitrate and phosphorous due to the use of
... Show More