Abstract

A sensitive, precise and reliable indirect spectrophotometric method for the determination of chlordiazepoxide (CDE) in pure and pharmaceutical dosage forms is described. The method is based on oxidative coupling reaction between amino group resulting from acidic decomposition of CDE with phenothiazine in the presence of sodium periodate to produce an intense green soluble dye that is stable and shows a maximum absorption at 602 nm. The calibration plot indicates that Beer’s law is obeyed over the concentration range of 0.1?50 µg/mL, with a molar absorptivity of 1×10⁴ L/mol cm and correlation coefficient of 0.9994.All the conditions that affecting on the stability and sensitivity of the fo

     Two rapid, simpleand sensitive flow injection methods were developed for the estimation of metronidazole (MRZ) in pharmaceutical formulations. The proposed methods were based on charge transfer reaction between metol (N-methyl-p-aminophenol sulfate) as a Ï€-acceptorand reduced MRZ as an n-donor to produce a blue colored chargetransfer complex. Method A depends on the reaction of reduced MRZ with metol (MT) in the presence of NaIO₄ using two lines manifold to form blue colored product exhibiting absorption maxima at 700 nm.While method B depends on charge transfer reaction of reduced MRZ with MT in presence of a solid phase reactorcontainingfixedFePO₄ on cellulose acetateusing reverse flow

A new mode of methodology was adopted in the assay of PM- HCL based on the use of water crystal gel bead made of poly acrylic acid in which the gel beads were left to absorbe persulphate solution that is necessary for the oxidation of PM- HCL in aqua media . The water crystal act as a reserviour for S2O82- . Optimum parameters were studied giving to specify the chemical and physical parameters. Two line manifold was used .The flow rates of 1.5 and 1.2 ml.min-1 was used , 3 gel beads , 120 μL sample volume , a linear dynamic range extend from 0.01- 18 mmol.L-1. A correlation coefficient (r) of 0.9991while the percentage linearity (r2%) of 99.82% with R.S.D% at 8 mmol.L-1 promethazine-HCl is less than 0.5% (ten replicates) and a detection

The first flow injection spectrophotometric method is characterized by its speed and sensitivity which have been developed for the determination of promethazine-HCl in pure and pharmaceutical preparation. It is based on the in situ detection of colored cationic radicals formed via oxidation of the drug with sodium persulphate to pinkish-red species and the same species was determined by using homemade Ayah 3SX3-3D solar flow injection photometer. Optimum conditions were obtained by using the high intensive green light emitted diode as a source. Linear dynamic range for the absorbance versus promethazine-HCl concentration was 0-7 mmol.L-1, with the correlation coefficient (r) was 0.9904 while the percentage linearity (r2%) was 98.09%. the L.

This piece of research work aims to study one of the most difficult reaction and determination due to continuous and rapid variation of reaction products and the reactants. As molybdenum (VI) aid in the decomposition of hydrogen peroxide in alkaline medium of ammomia, thus means a continuous liberation of oxygen which cuases and in a continuous manner a distraction in the measurement process. On this basis pyrogallol was used to absorbe all liberated oxygen and the result is an a clean undisturbed signals. Molybdenum (VI) was determined in the range of 4-100 ?g.ml-1 with percentage linearity of 99.8% or (4-300 ?g.ml-1 with 94.4%) while L.O.D. was 3.5 ?g.ml-1. Interferring ions (cations and anions) were studied and their main effect was red

The determination of manganese (II) using flow injection analysis with chemiluminescence detection was investigated. Mn2+ in sample solutions injected into a carrier stream of sodium bismuthate (NaBiO3) were oxidised to form MnO4- ions which were capable of producing luminescence after reaction with luminol/KOH in a flow cell. The linear range of the system is from 20 to 80 mg/L with a detection limit 8 mg/L. The proposed system is suitable for determination of Mn2+ in steel alloys after dissolution, filtration and dilution at a rate of approximately 60 samples per hour with a relative standard deviation (RSD)1.2%. Statistical comparison between the proposed system and standard spectrophotometric method revealed that there is no signific

A new simple sensitive and selective spectrophotometric method has been
developed for the analysis of vanadium(V) in three randomly chosen samples from
river water at different locations by continuous flow injection analysis. The method
based on the oxidation of pyrogallol by vanadium(V) in acidic solution to form color
species and the same species was determined using homemade Ayah 6SX1-T-2D
solar cell analyser . Chemical and physical parameters were investigated using the
high intensity of snow white light emitted diode as a source. The linear dynamic
range for the instrument response versus vanadium(V) concentration was 1-200
mg.L-1 with correlation coefficient r = 0.9920. The limit of detection (S/N=3) was 70<

A new simple sensitive and selective spectrophotometric method has been developed for the analysis of vanadium(V) in three randomly chosen samples from river water at different locations by continuous flow injection analysis. The method based on the oxidation of pyrogallol by vanadium(V) in acidic solution to form color species and the same species was determined using homemade Ayah 6SX1-T-2D solar cell analyser . Chemical and physical parameters were investigated using the high intensity of snow white light emitted diode as a source. The linear dynamic range for the instrument response versus vanadium(V) concentration was 1-200 mg.L-1 with correlation coefficient r = 0.9920. The limit of detection (S/N=3) was 70 ng/ sample from the step

A new method is characterized by simplicity, accuracy and speed for determination of Oxonuim ion in ionisable inorganic acid such as hydrochloric (0.1 - 10) ,Sulphuric ( 0.1 - 6 ),nitric ( 0.1 - 10 ), perchloric ( 0.1 - 7 ), acetic (0.1 - 100 ) and phosphoric ( 0.1 - 30 ) ( mMol.L-1 )acids. By continuous flow injection analysis. The proposed method was based on generation of bromine from the Bro-3-Br-- H3O+. Bromine reacts with fluorescein to quenches the fluorescence . A sample volume no.1 (31μl) and no.2 (35μl) were used with flow rate of 0.95 mL.min-1 using H2O line no.1as carrier stream and 1.3 mL.min-1 using fluorescein sodium salt line no.2. Linear regression of the concentration ( mMol.L-1 ) Vs quenched fluorescence gives a correla