A transdermal drug delivery system (TDDS) is characterized by the application of medications onto the skin's surface to deliver drugs at a controlled and predefined rate through the skin. Spanlastics, an elastic nanovesicle capable of transporting various pharmacological substances, shows promise as a drug delivery carrier. It offers numerous advantages over traditional vesicular systems applied topically, including enhanced stability, flexibility in penetration, and improved targeting capabilities. This study aims to develop meloxicam (MX)-loaded spanlastics gel as skin delivery carriers and to look into the effects of formulation factors like Tween80, Brij 35, and carbopol concentration on the properties of spanlastics gel, like pH, drug content, extrudability, spreadability diameter, viscosity, and release profiles in addition to Ex vivo skin permeation for optimal formula. The optimal formula of spanlastics gel (GF1) shows acceptable pH (6.2±0.14), excellent extrudability( 92%), drug content (97.1±0.14), spreadability diameter (cm) (10.8±0.28), sustained release 70.7±0.57% for six hours and the steady-state flux of meloxicam through rat skin was increased 83.52- fold as a result of spanlastics in comparison to the plain gel. The vesicles produced in this investigation could potentially interact with or merge with the stratum corneum as a result of their elasticity, which may also be the mechanism that increases the penetration into the skin. According to our findings, dermal delivery vehicles for MX may be provided via spanlastics gel
Speech is the ability of communication or expression of thoughts among people in spoken words. Human communication via speech is essential since any impairment in this process may have serious social and occupational consequences. Malocclusion is a possible cause of speech impairment in addition to many other etiological factors like hearing loss, neurological disorders, physical disorders, and drug abuse. This article throws light upon the association between speech disorders and malocclusion.
The research talks about the concept of investment allocations, showing its linguistic and idiomatic meaning, as well as the objectives for which the investment allocations are based, as well as the benefits of these allocations since it shows types of investment contracts, including: current and fixed assets and commitment allocations.
The research has been concluded with several results, including the protection of the banks and the investor. The contracting parties focus on specific dates that both parties are obliged to abide by, the research also shows the jurisprudence provisions for investment allocations, each ruling according to the specific branch.
... Show MoreBackground: Gingival recession is defined as the apical migration of the gingival margin below the cementoenamel junction (CEJ), resulting in exposure of the root surface and it is one of the main esthetic complaints of patients. The management of gingival recession and its sequelae is based on a thorough assessment of the etiological factors and the degree of tissue involvement.
Background: Dyslipidemia is a major cause of
cardiovascular disease, which in turn, is the most
common cause of female morbidity and mortality.
Postmenopausal women (natural and surgical) are at
higher risk of developing cardiovascular disease,
especially coronary artery atherosclerosis.
Objective: To observe the relationship between blood
lipids: total cholesterol (TC), high density lipoproteincholesterol (HDL-C), low density lipoproteincholesterol (LDL-C), triglycerides (TGs), and very low
density lipoprotein- cholesterol (VLDL-C), LDL-C/
HDL-C ratio (atherogenic index) and menopausal
status, and to determine the co-factors that may explain
this relationship
Methods: A prospective, cross-sectional st
ABU OBAYDA and Syntax Studies
Background: An important factor influencing duration of breastfeeding is mother’s employment status. The nutritional, immunological, psychological and economic benefits of breastfeeding are well documented. Both UNICEF and the World Health Organization recommend mothers should breastfeed exclusively for at least 6 months.
Objectives: To determine how the employment and the employment variables (type of work, time of return to work and hours of work) influence the breast feeding practices.
Methods: A cross- sectional study was carried out on a sample of 200 employed mothers who had their last child been completed at least tow years. Data were collected using a questionnaire form. It was carried out during the period from 1st of Ap
This research aims to deal with contemporary knowledge methodology to correlate between operations strategy and technological change or modernization in productive paths for industrial organizations depend on practical indicators for competitive priorities that is objectives of operations performance.
The research is based on main hypothesis, concentrates on determination of technological change which is decided by the level of technology deterioration in current operations path compared with the competitors leaders-technology leaders.
We apply these concepts on hypothetical case to two similar companies in their production nature and te
... Show MoreKE Sharquie, AA Noaimi, HA Salman, NA Hindy, Iraqi Postgraduate Medical Journal, 2009 - Cited by 1
S Khalifa E, N Adil A, S Husam Ali, H Nibras A…, 2009
It is no secret to anyone the lofty classifications and wonderful investigations made by Muslim scholars in various eras, with which they removed the dust of ignorance from the nation, clarified the argument, and illuminated the path of education, especially in the legal sciences, which are the foundation of religion.
It is the life of hearts and the path of grammarians in this world and the hereafter.
Among those scientific classifications are the investigations they have written in the science of the principles of legislation, which have established the general evidence and the original rules to which practical legal rulings are referred. And as you know, it is the basis of Islamic jurisprudence, a means of knowing its
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