Often phenomena suffer from disturbances in their data as well as the difficulty of formulation, especially with a lack of clarity in the response, or the large number of essential differences plaguing the experimental units that have been taking this data from them. Thus emerged the need to include an estimation method implicit rating of these experimental units using the method of discrimination or create blocks for each item of these experimental units in the hope of controlling their responses and make it more homogeneous. Because of the development in the field of computers and taking the principle of the integration of sciences it has been found that modern algorithms used in the field of Computer Science genetic algorithm or ant colony algorithm or bees algorithm or a swarm of birds and other originally used algorithm for the purposes of technology pertaining to distinguish between images or signals and others can be illustrated to serve the Census and check successful at it. So the choice fell on the genetic algorithm which often applied in the biology science on the subject of the analysis of DNA and genetic engineering within the modern trends of Medical Science. Proposal genetic algorithm was developed, along with C4.5 algorithm. Having been in this research integrating the work of all these algorithms mechanism Generalized Additive model to estimate some nonparametric function. Simulation was used to demonstrate the classification optimization using misclassification error and prove estimation optimization by the root mean of squares error: RMSE. The simulation has to experiment samples sizes (200, 400, 600) and (1000) replications