Synthesis and Characterization of Polycyclicacetal Derived from
PEG & Erythro-Ascorbic Acid Derivative and Study Its Effect on
the Activity of ACh Enzyme (In Vitro)
Polycyclicacetal
PEG
Acetylcholinesterase.
Polycyclicacetal was prepared from the reaction of PEG with aldehyde derived from Erythro-ascorbic acid (pentulosono-ɣ-lactone-2,3-enedianisoate).All these compounds were characterized by Thin Layer Chromatography (TLC) and FTIR spectra and aldehyde was also characterized by (U.V-Vis), 1HNMR, 13CNMR, and mass spectra.The inhibitory effect of prepared polymer on the activity of human serum AcetylCholinesterase has been studied in vitro. The polymer showed a remarkable activity at low concentration (4.7x10-3 – 4.7x10-8M).
