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Development and Validation of Spectrophotometric Methods for the Quantitative Determination of Doxycycline Hyclate in Pure Form and Pharmaceutical Formulations Using Flow‐Injection and Batch procedures: A Comparative Study
Abstract<p>Doxycycline hyclate is an antibiotic drug with a broad‐spectrum activity against a variety of gram‐positive and gram‐negative bacteria and is frequently used as a pharmacological agent and as an effector molecule in an inducible gene expression system. A sensitive, reliable and fast spectrophotometric method for the determination of doxycycline hyclate in pure and pharmaceutical formulations has been developed using flow injection analysis (FIA) and batch procedures. The proposed method is based on the reaction between the chromogenic reagent (V<sup>4+</sup>) and doxycycline hyclate in a neutral medium, resulting in the formation of a yellow compound that shows maximum absorbance at 396 nm. In a batch procedure, the proposed method was validated over the concentration range of 1.0–80 μg mL<sup>−1</sup> with a sampling frequency of 30/h, and commercial pharmaceutical samples were successfully determined. The proposed method was successfully adapted with an FIA system where the peak heights are proportionally connected to doxycycline hyclate over the concentration range of 25–400 μg mL<sup>−1</sup> with a sampling frequency of 50/h. The limits of detection (LOD) and quantification (LOQ) were 0.9 and 10.44 μg mL<sup>−1</sup> and 3.01 and 34.81 μg mL<sup>−1</sup> for batch and FIA respectively. The samples were submitted to an HPLC analysis, and the outcomes demonstrated excellent agreement with the suggested procedures. The adopted FIA procedure allows fast monitoring of doxycycline hyclate in pharmaceutical formulations and it can be used for quality control purposes during the production processes of doxycycline hyclate.</p>
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Publication Date
Sat Jan 30 2021
Journal Name
Iraqi Journal Of Science
Signal Soft Sets for Atoms Modeling and Signal Soft Topology

In this paper we define a signal soft set as a mathematical tool to represent and study atoms, anti-atoms, electrons, anti-electrons, protons, and anti-protons, and generate a signal soft topology, with an example of signal soft topology on H2O.

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Publication Date
Mon Jun 19 2023
Journal Name
Journal Of Engineering
Water Hammer Arresters; Review Studies and Practical Experiments for Alternatives

The current research deals with practical studies that explain to the Iraqi consumer multiple instances about the phenomenon of water hammer which occur in the water pipeline operating with pressure. It concern a practical study of the characteristics of this phenomenon and economically harmful to the consumer the same time. Multiple pipe fittings are used aimed to reduce this phenomenon and its work as alternatives to the manufactured arresters that used to avoid water hammer in the sanitary installations, while the consumer did not have any knowledge as to the non-traded for many reasons, including the water pressure decreases in the networks and the use of consumer pumps to draw water directly from the network. Study found a number of

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Publication Date
Thu Feb 28 2019
Journal Name
Journal Of Engineering
Activated Bentonite for Removal Nickle and Vanadium from Petroleum Distillates

The present work is to investigate the feasibility of removal vanadium (V) and nickel (Ni) from Iraqi heavy gas oil using activated bentonite. Different operating parameters such as the degree of bentonite activation, activated bentonite loading, and operating time was investigated on the effect of heavy metal removal efficiency. Experimental results of adsorption test show that Langmuir isotherm predicts well the experimental data and the maximum bentonite uptake of vanadium was 30 mg/g. The bentonite activated with 50 wt% H2SO4 shows a (75%) removal for both Ni and V. Results indicated that within approximately 5 hrs, the vanadium removal efficiencies were 33, 45, and 60% at vanadium loadings of 1

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Publication Date
Thu Oct 01 2015
Journal Name
Iraqi Journal Of Science
improvement and partial purification for pectinase production from pseudomonas aeuroginosa

Publication Date
Mon Jan 01 2018
Journal Name
Indian Journal Of Public Health Research &amp; Development
Nurses’ knowledge and practice toward oral care for intubated patients

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Publication Date
Wed May 25 2022
Journal Name
Iraqi Journal Of Science
Estimation of reservoir properties based on core plugs, lithofacies, and well logs for Nahr Umr Formation in Noor oilfield, southern Iraq

The Nahr Umr Formation, one of the most important Cretaceous formations and one of the main generating reservoirs in southern Iraq and neighboring regions, was chosen to study and estimate its petrophysical properties using core plugs, lithofacies, and well logs from five wells in the Noor oilfield. Reservoir properties and facies analyses are used to divide the Nahr Umr formation into two-member (limestone in the upper part and main sandstone in the lower). Limestone members are characterized by low reservoir properties related to low effective porosity and permeability while the main sandstone member is considered as a reservoir. Four lithofacies were recognized in the main sandstone member of the Nahr Umr Formation according to petrog

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Publication Date
Mon Jan 10 2022
Journal Name
Iraqi Journal Of Science
The Theoretical Solving of Intersection Point of the Horizontal and Vertical Gravity Gradients in Order to Estimate the Depth of Causative Source of Gravity Anomaly

The depth of causative source of gravity is one of the most important parameter
of gravity investigation. Present study introduces the theoretical solve of the
intersection point of the horizontal and vertical gradients of gravity anomaly. Two
constants are obtained to estimate the depth of causative source of gravity anomaly,
first one is 1.7807 for spherical body and the second is 2.4142 for the horizontal
cylinder body. These constants are tested for estimating the depth of three actual
cases and good results are obtained. It is believed that the constants derived on
theoretical bases are better than those obtained by empirical experimental studies.

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Publication Date
Sun Dec 20 2020
Journal Name
Journal Of Accounting And Financial Studies ( Jafs )
The impact of the reserve requirement ratio in the activity of the bank credit: Applied Research in a sample of Iraqi private banks

The research topic (The Impact of the Compulsory Reserve on the Banks Credit-an applied  research on    a sample of Iraqi banks), was chosen on basis of the Iraqi  private Banks attempts to increase their credit activities in hope to gain more profits.This coincided with  the CBI aim to back the private banking market.It is thus apparent why the CBI issued its regulation to those banks to increase their capitals up  to IDB250. On the other hand,the CBI acted as an obstacle in the way of increasing the private banks of their capitals,that is by implementing the quantitive  monetary tool  so called the compulsory reserve.This is why we intended to overlook at this contradictional  problome

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Publication Date
Thu Apr 29 2021
Journal Name
Iraqi Journal Of Science
The Effects of the Aqueous Extract of the Leaves of the Local Plant Eruca sativa on Lipid Profile and Some Minerals in the Blood of Male White Mice

Eruca sativa, commonly known as rocket salad, is a popular vegetable to which a wide range of health benefits are attributed. This study aimed to examine the effects of the aqueous extract of E. sativa leaves on lipid profile and some minerals, such as calcium and magnesium, in blood of male albino mice under normal physiological condition. Two experiments were separately conducted, each with eighteen male albino mice divided into 3 equal groups, which included control, treated group (1), and treated group (2) which were orally administrated with 0, 0.2 and 0.4 mg/kg body weight, respectively, of the leaves extract for 28 days. In the first experiment, serum lipid profile, including cholesterol, triglyceride, HDL, LDL a

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Publication Date
Fri May 18 2018
Journal Name
Thesis
The Arabian killifish (Aphanius dispar) as a novel model for mycophysiological studies.

Abstract Candida albicans is a commensal fungal pathogen that grows in yeast and hyphal forms in the human gut. C. albicans causes mucosal and cutaneous diseases that can result in significant mortality following systematic infections and it also exhibits drug resistance. Zebrafish have been an excellent model to investigate C. albicans infections because of their transparency and the availability of many transgenic lines. However, there is a limitation in using zebrafish as a model because the fish embryos cannot survive at 37°C therefore it is not suitable for studying Candida infections at physiological relevant human body temperature. In this thesis, the normal embryonic development of Arabian killifish (A. dispar) is investigated, rev

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