Cryptography is the process of transforming message to avoid an unauthorized access of data. One of the main problems and an important part in cryptography with secret key algorithms is key. For higher level of secure communication key plays an important role. For increasing the level of security in any communication, both parties must have a copy of the secret key which, unfortunately, is not that easy to achieve. Triple Data Encryption Standard algorithm is weak due to its weak key generation, so that key must be reconfigured to make this algorithm more secure, effective, and strong. Encryption key enhances the Triple Data Encryption Standard algorithm securities. This paper proposed a combination of two efficient encryption algorithms to satisfy the purpose of information security by adding a new level of security to Triple Data Encryption Standard algorithm using Nth Degree Truncated Polynomial Ring Unit algorithm. This aim achieved by adding two new key functions, the first one is Enckey(), and the second one is Deckey() for encryption and decryption key of Triple Data Encryption Standard to make this algorithm more stronger. The obtained results of this paper also have good resistance against brute-force attack which makes the system more effective by applying Nth Degree Truncated Polynomial Ring Unit algorithm to encrypt and decrypt key of Triple Data Encryption Standard. Also, these modifications enhance the degree of complexity, increase key search space, and make the ciphered message difficult to be cracked by the attacker.