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Biofunctionalization of polyetheretherketone implant material by bone-forming peptide-2 immobilization

Polyetheretherketone (PEEK) has favorable biomechanical properties to be used as an implant material. Unfortunately, it is hydrophobic and does not promote cellular adhesion, which could result in poor integration with bone tissue. Bio-functionalization of PEEK surface with osteogenic peptides derived from bone extracellular matrix proteins is an exciting approach to encourage bone formation around the implant. In the current study, bone-forming peptide-2 was immobilized on PEEK surface using two different methods, using dopamine and a diglycidyl ether as conjugate compounds, respectively. Peptide quantification test revealed that the two strategies resulted in the most amount of peptides were attached with 0.5 mM concentration and no further peptides were grafted with a higher peptide concentration. Both methods showed good peptide stability after agitation in aqueous solution. Peptide grafting was confirmed with ATR-FTIR. Surface characterizations with AFM and wettability tests resulted in a significant increase in surface roughness and surface area ratio for the peptide-grafted PEEK compared to unmodified PEEK, which led to a signifi-cant enhancement in the wettability of the modified PEEK surface

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Publication Date
Sun Apr 30 2023
Journal Name
Al-kindy College Medical Journal
The Oral Health Status in relation to Salivary Antimicrobial Peptide in Pregnant Women

Background: Oral health is a mirror of general health. During pregnancy, oral health is affected by changes in saliva and oral hygiene measures which may lead to more dental caries.

Objective: Assess oral health status in relation to salivary antimicrobial peptides in pregnant women.

Subjects and Method: This cross sectional study was carried out in different primary health care centers in Rusafa sectors/ Baghdad city. The total sample included was 80 women (their  age range from 21-30). The study group consisted of 40 pregnant women: half of them were in the first trimester and  others were in third trimester, while the control group included 40 non-pregnant married fem

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Publication Date
Tue Apr 26 2022
Journal Name
Journal Of Contemporary Medical Sciences
Doxorubicin Immobilization on chitosan-modified silver Nanoparticles as a drug delivery method for effective anticancer treatment

Objective: The goal of this research is to load Doxorubicin (DOX) on silver nanoparticles coupled with folic acid and test their anticancer properties against breast cancer. Methods: Chitosan-Capped silver nanoparticles (CS-AgNPs) were manufactured and loaded with folic acid as well as an anticancer drug, Doxorubicin, to form CS-AgNPs-DOX-FA conjugate. AFM, FTIR, and SEM techniques were used to characterize the samples. The produced multifunctional nano-formulation served as an intrinsic drug delivery system, allowing for effective loading and targeting of chemotherapeutics on the Breast cancer (AMJ 13) cell line. Flowcytometry was used to assess therapy efficacy by measuring apoptotic induction.  Results: DOX and CS-Ag

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Publication Date
Wed Jan 02 2008
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Β-Natriuretic Peptide Level as a Predictor for the Severity of LV Dysfunction

Background:
B -Natriuretic peptide is a neurohormone normally synthesized in ventricular heart muscle and known to be released in situations when left ventricular wall stress increases, it
has a variety of physiological functions on its own, that are thought to be compensatory.
Objective:
The aim of this study was to apply B-natriuretic peptide (BNP) as a biomarker and to correlate its levels with the severity of heart failure using certain selected parameters as
indicators of cardiac function.
Patients and Methods
Forty Six (46) patients with provisional diagnosis of heart failure were chosen for this work, thirty six (36) males and ten (10) Females, their age ranged between 33 and 80 Years.
All un

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Publication Date
Thu Mar 30 2017
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Synthesis of New Opioid Analgesic Peptide Analogues to Enkephalin (Leucine- and Methionine-Enkephalin)

A small number of researches were done in the design and synthesis of enkephalin analogues that are able to resist degradation effect of proteolytic enzymes with good bioavailability and half-lives.Through studying structure activity relationships we tried to incorporate phthalyl group, tryptophan and lysine amino acids in different positions in the basic backbone structure of the naturally occurring opioid Leu5- and Met5- enkephalin, in the hope that such insertion of these amino acids could induce interesting addition in the biological activity of these analogues with enhancement of their bioavailability, in addition to decrease side effects as addiction liability.

These synthesized peptides are:

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    Publication Date
    Wed May 17 2023
    Journal Name
    Journal Of Engineering
    The Effect of Tool Path Strategy on Twist Behavior In Single Point Incremental Sheet Metal Forming

    In Incremental sheet metal forming process, one important step is to produce tool path, an
    accurate tool path is one of the main challenge of incremental sheet metal forming
    process. Various factors should be considered prior to generation of the tool path i.e.
    mechanical properties of sheet metal, the holding mechanism, tool speed, feed rate and
    tool size. In this work investigation studies have been carried out to find the different tool
    path strategies to control the twist effect in the final product manufactured by single point
    incremental sheet metal forming (SPIF), an adaptive tool path strategy was proposed and
    examined for several Aluminum conical models. The comparison of the proposed tool path with t

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    Publication Date
    Sat Sep 30 2017
    Journal Name
    Al-khwarizmi Engineering Journal
    Study the Effect of Multilayer Single Point Incremental Forming on Residual Stresses for Bottom Plates

    Abstract

     

    Knowing the amount of residual stresses and find technological solutions to minimize and control them during the production operation are an important task because great levels of deformation which occurs in single point incremental forming (SPIF), this induce highly non-uniform residual stresses. In this papera propose of a method for multilayer single point incremental forming with change in thickness of the top plate (0.5, 0.7, 0.9) mm and lubrication or material between two plates(polymer, grease, grease with graphite, mos2) to knowing an effect of this method  and parameters on residual stresses for the bottom plates. Also compare these results for the

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    Publication Date
    Mon Jun 05 2023
    Journal Name
    Al-khwarizmi Engineering Journal
    Fabrication and Analysis of Denture Plate Using Single Point Incremental Sheet Forming

    Incremental sheet forming (ISF) is a metal forming technology in which small incremental deformations determine the final shape. The sheet is deformed by a hemispherical tool that follows the required shape contour to deform the sheet into the desired geometry. In this study, single point incremental sheet forming (SPIF) has been implemented in dentistry to manufacture a denture plate using two types of stainless steel, 304 and 316L, with an initial thickness of 0.5mm and 0.8mm, respectively. Stainless steel was selected due to its biocompatibility and reasonable cost. A three-dimensional (3D) analysis procedure was conducted to evaluate the manufactured part's geometrical accuracy and thickness distribution. The obtained results confirm

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    Publication Date
    Thu Jan 31 2019
    Journal Name
    Journal Of The College Of Education For Women
    A New Vision in the Locality and the Factors of Forming Meander

    The research addressed an analytical field investigation of the locality of meander, the factors responsible of the locality of the meander at certain points of the stream other than others, and the role sequence of these factors in the formation process.
    The research revealed that the location of forming the meander was associated closely with the scale structural composition of the bank materials from which the first stage of forming the curved stream, for the inhomogeneous or non-identical opposite banks in their scale structural composition saw an activity of differential corrosion, while the homogeneous and identical opposite banks in their scale structural composition saw an identical corrosion activity in its intensity at both

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    Publication Date
    Wed Nov 07 2018
    Journal Name
    Iraqi National Journal Of Nursing Specialties
    Evaluation of the Hardness of Cold Cured Acrylic Resin Material by Processing at Different Temperature

    Objective(s): This study aims to evaluate the hardness of two commercially available cold cured acrylic resin material
    (Vertex and PAN) when polymerized at different temperature in comparison to those polymerized by conventional
    methods in air at 23C ± 5C.
    Methodology: Eighty specimens, forty from cold cured acrylic (Vertex Type) and forty from cold cured acrylic (PAN
    type) were prepared, flasking and packing procedure were done according to manufacturer direction and divided
    according to processing as follow: 20 specimens (10 from Vertex type and 10 from PAN type) were processed in air for
    two hours at 23C ± 5C under press (bench curing) as a control, and 60 specimens (30 from Vertex type and 30 from
    PAN type) wer

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    Publication Date
    Wed Mar 29 2023
    Journal Name
    Journal Of Optics
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