Background: Human leukocyte antigen (HLA) is the most polymorphic genetic system in man. The genes of this region seem to influence susceptibility to certain diseases.
Patients and methods: Polymerase chain reaction-Sequence Specific Primers PCR-SSP is the method used to asses HLA-typing of 100 blood samples of 60 AIH patients and 40 healthy normal controls.
Results: An increased frequency of HLA-DR3, DR4 and DR7 was observed for patients group versus control group with P-value (0.0001, 0.05, and 0.001) respectively, while DR*0211 (DR2) may be formed the basis for protection against the disease. HLA-DQ on the other hand, yielded on association in Iraqi patients with AIH.
Conclusions: This finding de

Background: Urany1 acetate (UA) mostly a kidney poison or chemical toxic and not nearly so much radiological also is not accumulative toxic, so it is not concentrated in the food chain nor would it cause pathological condition due to increase levels from expomers. Therefore, the study aimed to detect the target organ as most of the lethal dose (LD50) male rats died within 24 hours.
Methods: Study was done on (120) male rats of 2 months old, at varying dosage level of uranyl acetate ranging from LD 50 of 2.5 and 1.5gm/kg and varying dosage level, by oral intubation. There were (40) rats for LD 50 were given single oral dose from 2.5 to 1.5 gm /kg every day. Eighty rats for the main study, (20) rats each gr

Background: Polycythemia (or polycythaemia or erythrocytosis) is a condition in which there is a net increase in the total number of blood cells, primarily red blood cells, in the body. The overproduction of red blood cells may be due to a primary process in the bone marrow (a so-called myeloproliferative  syndrome), or it may be a reaction to chronically low oxygen levels or, rarely, a malignancy. Minerals are the building blocks of our bodies. They are required for body structure, fluid balance, protein structures and to produce hormones. They are the key for the health of every body system and function. They act as co-factors, catalysts or inhibitors of all enzymes in the body .
Patients and Methods: B

خلفية الموضوع: المالاسيزيا خميرة أحادية القطب تتعايش على الجلد وقد تكون ممرضة تحت بعض الظروف البيئية. خميرة المالاسيزيا معروفة كنبيت طبيعي للفقريات ذوات الدم الدافئ. الصدفية هو مرض جلدي غير معروف المسبب، يُعتقد بأن الفطريات قد تثير الأمراضية.

الأهداف: على الرغم من أن دور المالاسيزيا ما زال غير مفهومة تماما في أمرضية الصدفية ، ويعتقد أن هذه الخمائر محبة للدهو

Background: Infectious mononucleosis (IM) is a lymphoproliferative disease caused primarily by the Epstein-Barr virus (EBV) infection. The initial viral infection by EBV occurs in B lymphocytes and is followed by an extensive proliferation of T lymphocytes. Previous studies on immunity to EBV (including IM) have mainly focused on activation of peripheral blood T cells, which are responsible for the lymphocytosis in blood during acute IM.
Patients and Methods: Indirect immunofluorescence technique analysis was performed to detect the percentage of CD3, CD4, CD8, CD19, and CD56 positive lymphocytes.
Results: Our results on the phenotype of T cells in samples from patients with infectious mononucleosis sh

Background: The umbilicus, before and shortly after sloughing of the cord, can be a source of infection or toxicity. The infection can be severe, such as septicaemia
or tetanus neonatorum.
Method: Mothers of 200 neonates seen at the Children Welfare Hospital, outpatient department, Baghdad, and at Al-Takia health centre, Baquba, were interviewed about the separation of the umbilical stump and the care of the umbilicus after delivery at home or hospital, in the period, January to July 2003, excluding March and April, the time of active military invasion of the country.
Results: For occlusion of the cord a plastic clamp was used in all hospital deliveries, and 80% of home deliveries. A cotton thread or a s

Background: Inhibitor development and HCV are considered the most serious complications of hemophilia treatment. Many factors may increase the risk of complications which include: type of hemophilia, age of the patient, age of onset, duration of the disease, & number of replacement per month. Patients and methods: A descriptive study included 200 patients less than 20 years of age admitted to the Hemophilia Center in Children Welfare Teaching Hospital , medical city in Baghdad , their data ( ag , sex , disease onset and duration , severity of hemophilia ) were collected over 8 months period from 1st January to 31st August 2006. Mixing tests and serology tests for HCV and HBV were performed for all patien

Background: Glomerular injury can be caused by immunologic, infectious, toxic, metabolic and heamodynamic factors. The glomerular response to injury determines the pathology, which can be observed in renal biopsy. The purpose of this study was to analyze different histopathological subtypes of primary and secondary glomerular diseases in children.
Patients and methods: A retrospective study was done on 100 renal biopsy cases in children welfare teaching hospital between December 2003 and December 2007. Ultrasonically guided
biopsies were taken and only light microscopy was used to examine the specimens.
Results: The study group included 100 cases with renal diseases, 83 (83%) cases of which having primar

Background: CA19-9 is among a group of mucin glycoprotein sialosyl lewis antigen (SLA) having come to be recognized as a circulating cancer associated antigen for gastrointestinal cancer. Basic research into cancer causation will be a powerful determinant of intervention in the transformation process reinforcing the need for developing effective molecular tumor biomarkers for early detection of malignant evolution in tissues of organs i.e. stomach, colon and rectum. In this study, we make a comparsion between the levels of CA19-9 in sera and tissues of patients with these diseases to see if their levels are proportional and if it is a tumor marker that affect with malignant cells in tissues of these org

Background: a rapid and accurate identification of Methicillim-Resistant Staphylococci (MRS) is of a particular clinical significance because they have cross-resistance to other antibiotics with high ability to be transmitted among hospitalized patients known as epidemic MRS.
Objectives: the detection of MRS and the susceptibility of isolates to antimicrobial agents, also to determine inducible and constitutive macrolide-lincosamide-streptogramin B (MLSB) resistance mechanisms by pharmacodynamic interpretative reading approaches.
Methods: standard disk diffusion method was performed for 30 Staphylococcus aureus and 10 Staphylococcus epidermidis isolated from wound, burn patients admitted to Ramadi General Hospital in Ramadi and e

Background: Study the correlation between the left ventricular end diastolic volume (LVEDV), ejection fraction (EF) and the development of arrhythmia.
Patients and methods: Two hundreds patients with documented acute coronary syndrome and myocardial infection with dysrhythmia documented by ECG and holter monitoring assessed at the cardiac department at Baghdad teaching hospital over the period Jan-Dec 2007. These dysrhythmias were corelated with left ventricular end diastolic volume and ejection fraction.
Results: The patients were divided into 4 groups according to LVEDD and EF. The 1st group, 40 patients (20%) found to have non sustained ventricular tachycardia was associated with higher LVEDD (62-72

Background: The critically ill patient is at risk of developing intensive care acquired infection, with the lungs being especially vulnerable. Ventilator associated pneumonia (VAP) occurring after two days of mechanical ventilation and it is the most nosocomial infection seen in the intensive care unit .The establishment of an accurate diagnosis of ventilator associated pneumonia remains problematic and yet there is still no accepted "gold standard" for the diagnosis.
Patients& Methods: This is a cross section study for 328 patients admitted to intensive care unit at medical city teaching hospital. Full history, physical examination and investigation were done after 48 hours of admission according to

Objective: To determine the prevalence of hepatitis C virus (HCV) infection among blood donors and risky population in Diyala province.<br />Materials and methods: In this retrospective study, the records of HCV screening and confirmatory tests were reviewed for the period 1996-2001.Third generation Enzyme-linked immunosorbant assay (ELISA) and Enzyme immunoblot assay were used as screening and confirmatory tests respectively.<br />Results: The prevalence of HCV infection among blood donors was 0.15%, with the highest in 1997. The highest prevalence rates were found among multiple blood recipient; hemophilia, thalassemia and hemodialysis patients (27.3%, 16.9% & 14.3%) respectively. Whereas, the patients with chronic hepa

الخلفية: المركبات الحلقية غير المتجانسة ومشتقاتها لها فعالية بايولوجية وتستخدم كمسكن للألم، طارد للديدان، مضاد للسلس، مضاد للفطريات، مضاد للفيروسات، مضاد للسرطان وعامل مثبط لبعض الأنزيمات. مشتقات الأوكسازبين تستخدم ملطف للعصاب النفسي الناتج من الحصر والشد العصبي. انزيم الفوسفتيز القاعدي يحلل الاستر احادي الفوسفات، وانزيم اللاكتيت منزوع الهيدروجين يساعد على اكسدة اللاكتيت الى باي

الخلفية : التهاب المفاصل الرثوي هو مرض مناعي شائع ومزمن ومدمرللمفاصل,العلاج بعقار إينفليإكسيمب يعطي تحسنا كبيرا لأعداد كبيرة من المرضى الذين يعانون من التهاب المفاصل الرثوي ، ولكن في بعض المرضى بعد العلاج لفترات طويلة بالإينفليكسيمب يمكن أن تحفز تكوين الأجسام المضادة المقاومةللإينفليكسيمب و يؤدي إلى فقدان فعالية إينفليكسيمب و استمرار المرض النشط.الهدف : التحققفي وجودالاجس

الخلاصة:الكلكتين-4  هو واحد من العائلة البروتينية المرتبطة بالكلايكوسيدات نوع  بيتا و التي تتعرف على مجموعة متنوعة من البروتينات التي تحوي الكلايكان على سطح الخلية وتفرز بغزارة في الأورام المختلفة، بما في ذلك سرطان المعدة.

ارتبطت غزارة الكلكتين -4  فضلا عن التغيرات في توزيعها التحت خلوية مع تطور سرطان المعدة وسوء مأّل الحالة قد توفر المعلمات الجزيئية التش

الملخص : تم الكشف عن الأجسام المضادة السيتوبلازمية المضادة للمتعادلة ( ANCA ) للمجموعات الفرعية الثانوية ( ايلاستيز ، اللايزوزايم ، كاثيبسين ج ، اللاكتوفيرين و BPI ) بين مرضى داءالذئبة الاحمراري تسبب التهاب الأوعية الدموية : .داء الذئبة الاحمراري ( SLE ) هو مرض معقد المناعي والتي تتميز بإنتاج الأجسام المضادة المفرط، و تشكيل مجاميع مناعية، و إصابة الأنسجة بوساطة مناعيا .

ا

الخلفية:  ان نقص التروية القلبية-اعادة التسريب (I / R) إصابة قد تحدث في مجموعة متنوعة من الحالات  السريرية وهذا يمثل مشكلة كبيرة. وقد ثبت ان جذر الأوكسجين الحر  ينتج خلال اعادة التسريب ويلعب دورا كبيرا في عضلة القلب إصابة I / R. وقد وصفت الآثار العلاجية المختلفة  لنبات الزعرور. بالإضافة إلى ذلك، اوضحت الدراسة  أن نبات زعرور له تأثير وقائي ضد الاصابة بنقص التروية القلبية واعادة ضخ

الخلفية: التهاب المفاصل الرثوي هو مرض مناعي حيث يقوم جهاز مناعة جسم الانسان بمهاجمة انسجة مفاصل الحركة مما يتسبب في حدوث التهاب في تلك المفاصل. يعتبر المعلم السطحي CD69 هو بروتين من نوع ليكتين C  و مسيطر عليه بواسطة جين CD69 ، و ان اي تحفيز للخلايا اللمفاوية نوع (  (Tو الخلايا القاتلة نوع (NK) في داخل الجسم او خارجه سيؤدي الى زيادة ظهور هذا المعلم على سطح الخلايا ولذلك فان اي ظهور موجب لمعلم C

Background: Assessment is an important part of the learning cascade in education. Students realize it as an influential motivator to direct and guide their learning. The method of assessment determines the way the students reach high levels of learning. It has been documented that one of factor affecting students’ choice of learning approach is the way how assessment is being performed. Many methods of assessment namely multiple choice questions, essay questions and others are mainly used to assess basic science knowledge in undergraduate education. Objectives: The aim of this study is to compare multiple choice questions (MCQ) and essay questions (EQ) (record the success and failure rate of multiple choice questions (MCQ) and essay qu

Background: The study was conducted to investigate the association between hyperprolactinaemia and markers of human leukocyte antigen (HLA) system in a sample of Iraqi infertile females, together with the profile anti-nuclear antibodies (ANA).
Objectives: One hundred and seventy five female patients (age range: 20 -40 years) were recruited in this study. They were attending the Institute for Embryo Research and Infertility Treatment (Al-Nahrain University) during the period January 2005 - September 2006.
Results:After clinical and laboratry evaluations, it was found that 100 patients were hyperprolactinaemic, whereas the other 75 patients were euprolactinaemic, therefore, they were considered as a control group. Based on serum le

Background:Breast carcinoma is the most common malignant tumor and the leading cause of carcinoma death in women, with more than 1,000,000 cases occurring worldwide annually.(1) as a matter of fact , the mortality rate for breast carcinoma changed very little from the 1930s to the early 1990s, because of the combined action of earlier diagnosis and improved therapy .<br />Materials and methods: The prospective study included 500 cases of breast carcinoma who went total mastectomy , between October 2006- April 2007, where taken from private pathology laboratory , sections(4microns) are taken and stained with H&E stain and over-reviewed.<br />Results: Clinicopathological analysis of the 500 cases of breast carcinoma, includ

خلفية: احتشاء عضلة القلب (MI) هو الأكثر شيوعا نظرا لانسداد (انسداد) في الشريان التاجي بعد تمزق لوحة تصلب الشرايين عرضة للخطر. وقد اقترح أن الأنسجة الدهنية قد تلعب دورا مهما في التوسط في هذه العملية التهابي مزمن. وتشارك الاستجابات الالتهابية في بدء وتطور لويحات تصلب الشرايين. رزيستين هو ببتيد السيستين الغنية التي أعرب عنها في مستويات منخفضة نسبيا في adipocytes الإنسان، ولكن مستويات أعلى في الضامة. الأنس

خلفية: هناك أدلة كثيرة على القلب والأوعية الدموية التي تربط الاعتلال والوفيات مع السمنة، ولكن، لها تأثير مباشر للسمنة غير معقدة في وظيفة القلب ليست راسخة.

الهدف: لتقييم العلاقة بين مؤشر كتلة الجسم (BMI) واليسار هيكل البطين وظيفة.

الطرق: أجريت هذه الدراسة مستعرضة خارجا على (146) البالغين الأصحاء على ما يبدو من كلا الجنسين (85 من الذكور والإناث 61) تتراوح أعمارهم بين 20-59

Background: Congenital adrenal hyperplasia is a family of autosomal recessive disorders of cortisol biosynthesis. Depending on the enzymatic step that is deficient, there may be signs, symptoms, and laboratory findings of mineralocorticoid deficiency or excess; incomplete virilization or premature puberty in affected males; and virilization or sexual infantilism in affected females. The most frequent is 21-hydroxylase enzyme deficiency, accounting for more than 90% of cases.
Objectives: to review cases of congenital adrenal hyperplasia registered in children welfare teaching hospital- medical city- Baghdad.
Patients and method: This study included all patients who were presented and registered in the e

Background: Although the issue of anemia after renal transplantation (RT) has received increasing attention lately, the data on the exact prevalence of post-transplantation anemia (PTA) in the Iraqi patients are limited.
Objective: In this study we sought to determine the prevalence of PTA among Iraqi patients and to correlate the renal allograft function measurements and the use of immunosuppressant with the prevalence of anemia.
Patients and Methods: One hundred and twelve (74 male, 38 female) kidney transplant recipients (KTR) attending the kidney transplant center at surgical specialties hospital were studied. All patients were on maintenance, combined immunosuppressive therapy. The renal function

Background: one of the complications of rigid bronchoscope is the cardiovascular responses that may carry a dangerous drawback during and after the procedure. Prevention and control of these events will be crucial, especially for the old and cardiovascular debilitated patients.
Objective: The study aims to control and attenuate the unwanted hemodynamic responses to the rigid bronchoscpe using intravenous lidocaim and GTN.
Method: a study was performed on three groups of patients undergone a diagnostic procedure of bronchoscope. Each group consists of 20 patients at the same age and relatively similar pathology. The three groups (group one, two and three) received lidocaine, glyceryltrinitrate and no drug re

الخلفية: يعتبر سرطان القولون ذو انتشار كثير في مناطق شمال اوربا, واميركا الشمالية وبريطانيا العظمى ولكن بنسب قليلة في افريقيا واسيا واميركا الجنوبية. هنالك الكثير من المعلمات المناعية التي تتفاعل مع انسجة القولون, فان كثير من سرطان القلون والمستقيم يتفاعل مع (mucin), كذلك يتفاعل سرطان القولون والمستقيم مع (cytokeratins) , وايضا مع CARCINOEMBRYONIC ANTIGEN (CEA).

وهناك الكثير من المعلمات الخر

الخلفية: سابقا كان داء السكري من النوع الاول من بين اسباب تاخر النمو الشديد. العراق تعرض للحروب والصراعات التي اثرت على الخدمات الصحية والتي بدورها اثرت على حالة السكر في الدم لمرضى السكري.

الهدف: تقديم تقريرعن نمو الاطفال المصابين بالسكري في العراق بعد انتهاء الصراع.

طريقة البحث: شملت الدراسة 100طفل مصاب بداء السكري من النوع الاول وا

خلفية البحث:الكتل الحوضية شائعة في النساء ويمكن أن تحدث  في أي عمر من حياة المرأة، يمكن أن تكون حميدة أو كتلة خبيثة ويمكن أن تنشأ من الأعضاء التناسلية الأنثوية مثل عنق الرحم، الرحم، ملحقات الرحم، أو من أجهزة الحوض الأخرى مثل الأمعاء والمثانة والحالب والهيكل العظمي العضلات، والعظام.

 الهدف من الدراسه : تحديد كل من الزيادة في عدد الصفائح الدموية (&g