Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512)
University of Baghdad- College of Pharmacy
Journal Website
ISSN:
2521-3512
eISSN:
1683-3597
Statistics
No. of publications:
841
No. of views:
1745501
No. of Scopus citations:
2394
No. of Crossref citations:
1636
SNIP 2025:
0.639
SJR 2025:
0.278
CiteScore 2025:
2.6
CiteScore 2026:
2.3
Publication Date
Sat Jun 19 2021
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Formulation and Characterization of Isradipine Nanoparticle for Dissolution Enhancement
Keywords: Nanoparticles
Isradipine
Dissolution rate enhancement
Isradipine belong to dihydropyridine (DHP) class of calcium channel blockers (CCBs). It is used in the treatment of hypertension, angina pectoris, in addition to Parkinson disease. It goes under the BCS class II drug (low solubility-high permeability). The drug will experience extensive first-pass metabolism in liver, therefore, oral bio-availability will be approximately15 to 24 %.
The aim of this study was to formulate and optimize a stable nanoparticles of a highly hydrophobic drug, isradipine by anti-solvent microprecipitation Method to achieve the higher in vitro dissolution rate, so that it will be absorbed by intestinal lymphatic transport in order to avoid hepatic first-pass metabolism&nbs
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