Scrophularia. striata from Scrophulariacea family has been used in Iranian folk medicine for the treatment of infectious diseases. In this study we evaluated the synergistic effect of S. striata   hydroalcoholic extract (SSE) and commercially available antibiotics against P. aeroginosa and Methicillin- resistant Staphylococcus aureus (MRSA). The resazurin-based microdilution method was used to determine the minimum inhibitory concentration (MIC) values of plan extract and standard antibiotics. The interaction between standard antibiotics and SSE was evaluated by using checkerboard method. The results of this study revealed that SSE enhance the antibacterial activity of antibiotics. The combin

Until today, one of the leading predominant infections is Urinary tract infection (UTI). It exerts a huge burden on health systems worldwide each year. Treating UTIs empirically with antimicrobials improves morbidity rates. This study aims to assess the prevalence of UTI-associated bacteria in adult patients and to determine their antibiotic susceptibility profile. A retrospective study was conducted for adult outpatients who visited Al-Diwaniya tertiary hospitals from January 2020 till February 2022 to review their medical and lab records in addition to sociodemographic data. A total of 256 patients’ records were included of which 204 (79.7%) belong to females and 52 (20.3%) were males with an average age of 39.22±17.10 years. The pr

Abstract

                Bilastine (BLA)  is a modern second – generation antihistamine employed to manage symptoms associated with allergic rhinoconjuctivitis and urticaria. However, it is very slightly soluble in water with low bioavailability, which affects its therapeutic action. The main objective of this research was to enhance the solubility and dissolution rate of BLA by complexation technique using beta cyclodextrin)β-CD)  and its derivatives,  hydroxypropyl beta cyclodextrin) HP-β-CD), methyl beta cyclodextrin(M-β-CD), and sulfobutyl ether beta cyclodextrin (SBE-β- CD) . Binary and ternary complexes using dif

The pharmacokinetics and bioequivalence of a newly developed extended-released (ER) tablet containing 400 mg pentoxifylline as a test product was compared with the reference brand product Trental^® 400 mg ER tablet produced by Sanofi-Aventis. Two separate studies were conducted simultaneously. The first study was conducted under fasting condition, whereas, the second study was conducted under fed condition; using the same batches of the test and reference products in both studies. In each study, both products were administered to 32 healthy male adult volunteers applying a single-dose, two-treatment, two-period, two-sequence, randomized crossover design with one-week washout period between dosing. Twenty two blood samples we

  The preferred route of drug administration is the oral route, but drugs with narrow absorption window in the gastrointestinal tract are still challenging. The ability to extend and monitor the gastric emptying time is a valuable tool for processes remaining in the stomach longer than other traditional dosage forms.

The purpose of this study was to formulate and evaluate gastroretentive superporous hydrogel (SPH) of carvedilol with view to improve its solubility and increase gastric residence time in order to get sustained release formulas via utilization of various kinds and concentrations of hydrophilic polymers then after, incorporate the best prepared formula into capsules.

 Sixteenth formulae of SPH h

Liver is considered as the first target for the toxic effects of toxins and other xenobiotics, and this can be attributed to its role as a site which receive all absorbed xenobiotics from the gastrointestinal tract and its role as a major site for biotransformation of xenobiotics. The present study was designed to evaluate the possible hepatoprotective effect of benfotiamine against CCl₄-induced hepatotoxicity in rats. The study was conducted on 48 male albino rats; the animals were allocated into 8 groups (6 rats in each group) and treated as follow: 4 groups treated with oral doses of either normal saline, benfotiamine (100 mg/kg), thiamine (100 mg/kg), N-acetylcystein (400 mg/kg) only without induction of hepatic damage. Th

Breast cancer is the leading cause of death and is the most frequent disease among women. Tamoxifen is an antiestrogen used to treat breast cancer. It may completely halt the disease's progression in high-risk individuals and lower the risk of death and recurrence in premenopausal and postmenopausal women. Variations in tamoxifen responsiveness between individuals may be attributed to polymorphisms in the primary metabolizing enzyme CYP3A4. The wild genotype (GG) of rs35599367 was found to be most common in 100 female breast cancer patients who were hormone receptor positive and taking tamoxifen, according to the study. This genetic variation may have a significant impact, as the GG genotype is strongly linked to significantly lower leve

Kaempferia parviflora (KP), also known as Black ginger or Kra-chi-dum in Thailand, is a Zingiberaceae plant native to Thailand and Malaysia. This plant is commonly used by the community as a spice in cooking and healthy drinks for disease prevention and treatment. According to research, KP extracts have broad bioactivity against infectious diseases caused by viruses and bacteria, as well as diseases related to metabolic disorders such as obesity, diabetes, aging, and gastrointestinal disorders. KP is also effective as an anticancer agent. This review article focuses on KP's anticancer activity and possible mechanisms of action. Furthermore, the botanical aspect and content of active compounds are investigated in this ar

Extract from cell culture of medicinal plant like Nigella sativa have been assessed for its cytotoxic properties. Thymol is likely responsible for the theraputic effects of  Nigella sativa leaf callus extract. In this short study the inhibitory effect of Nigella sativa leaf callus extract (Thymol) has been studied on Human Lorgnx Epidrmoid Carcinoma (Hep-2) cell line during different exposure period of time (24, 48 and 72 hrs.) using different concentration of the extract (1000, 500, 400, 300, 200 and 100 µg/ml). The optical density of the Hep-2 cells has been readed on 492 nm wave length. Thymol –induced cytotoxicity was (500 µg/ml) which inhibit cell growing compared to the control and this

Patients who have implantable cardioverter defibrillators (ICD) are challenged with multiple physical, psychological, and social complications. It is important to understand ICD patients’ knowledge about safe measures post-implementation. The study aims to assess patient’s knowledge of the safe measures after implantable cardioverter defibrillator. A descriptive-analytical study was carried out from October 19th, 2022 to January 16th, 2024 to determine the patient’s knowledge about safe measures after ICD. Non-probability (purposive) sample of 70 Patients with an ICD during routine checking and programming the device in outpatient at Ibn – Al-Bitar specialized center in Baghdad city. The study instrument was composed of three par

Disulfiram (DSF), an FDA-approved pharmaceutical for the management of alcoholism, has demonstrated its efficacy against several kinds of cancer. DSF has limited solubility, fast metabolism, short duration of action, and instability in physiological environments, mostly caused by rapid degradation in the acidic gastric environment, Therefore, a transdermal gel containing disulfiram, which was loaded into invasomes, was developed to improve the stability of DSF and enable its effective distribution to tumor tissues. The optimal invasomal dispersion was developed in the laboratory using a 4:1 ratio of soya-phosphatidylcholine (SPC) to disulfiram, and 1% carvacrol as a penetration enhancer. Furthermore, three invasomal gel formulas (IV-g1,

Triazole antifungal drug voriconazole inhibits the fungal ergosterol synthesis and reacts very well against a wide range of fungal species. Organogel is a semisolid preparation in which the polar phase becomes immobilized within the three-dimensional structure. It would be ideal to have a topically applied form of voriconazole organogel to avoid undesirable systemic side effects and to reduce the dosage by coming into direct contact with the pathological site. This study aimed to formulate topical voriconazole organogel, consisting of a low molecular weight gelator (palmitic acid) at different concentrations with oleic acid, grape seed, and sesame oil. A solubility study revealed that voriconazole was highly soluble in the chosen oils. S

   The new Iraqi health insurance plan was approved by the Iraqi parliament in 2021 and became a law that should be implemented in the next couple of years. This study is collaboration between the University of Baghdad/ College of Pharmacy and the Health Insurance Authority which is the responsible body for the new health insurance program implementation. The study aimed to measure the general population's awareness and acceptance of the new national health insurance program in order to get over any obstacles that might arise during the implementation process. This study was a cross-sectional study using an electronic survey for the general population. A Google Form was used to distribute the survey via social media platforms. The surv

Metal-organic frameworks-5 (MOF-5) were explored for enhancement of the solubility and dissolution of the drug niclosamide (NIC). MOF-5 was synthesized by solvothermal method and NIC was loaded into it (NIC@MOF-5). Characterization was done using field-emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Brunauer-Emmett-Teller surface area (BET-SA), and energy-dispersive X-ray spectroscopy (EDS). The effect of loading time on the percentages of entrapment efficiency (%EE) and loading capacity (%LC) were studied. The effect of incorporation into MOF-5 on saturated solubility and dissolution profiles of NIC was investigated in three different media: acidic buffer solution

Pre-eclampsia is the most common medical complication of pregnancy associated with increased maternal and infant mortality and morbidity. Its exact etiology is not known, although several evidences indicate that various elements might play an important role in pre-eclampsia. This study was carried out to analyze and to compare the concentration of calcium, in mild pre-eclampsia and in normal pregnant women , and to determine the effect of oral supplementation with calcium on mild pre-eclampsia  , and whether this effect is related to the change in the level of serum calcium. Forty- five women  in the third trimester of pregnancy were selected to participate in this study and divided  into: fifteen apparently healthy, normo

           The plants of genus Heliotropium L. (Boraginaceae) are well-known for containing the toxic metabolites called pyrrolizidine alkaloids (PAs) in addition to the other secondary metabolites. Its spread in the Mediterranean area northwards to central and southern Europe, Asia, South Russia, Caucasia, Afghanistan, Iran, Pakistan, and India, Saudi Arabia, Turkey, and over lower Iraq, Western desert. The present study includes the preparation of various extracts from aerial parts of the Iraqi plant. Fractionation, screening the active constituent, and identification by chromatographic techniques were carried out.Heliotropium  europaeum

Fast dissolving film can be defined as a dosage form, which when placed in the oral cavity. It will rapidly disintegrate and dissolves to release the medication for oral mucosal absorption or allow for the gastrointestinal absorption to be achieved when swallowed.

Flurbiprofen is non-steroidal anti-inflammatory agent with antipyretic and analgesic properties and can be used   in low doses 8.75 mg as analgesic and anti inflammatory agent in sore throat infection. This study aims to   formulate flurbiprofen as oral dissolving films,   to improve the effective relief of pain with severe sore throats with little or no adverse effect.

Nine formulas were prepared using solvent-casting method, and t

Epidermal growth factor receptor tyrosine kinase (EGFR-TK) is a vastly fascinating epigenetic target for medicine treatment. EGFR-TK is overexpressed in several diseases, including cancers. In this study, we designed new EGFR-TK inhibitors with the same consists of erlotinib (approved anticancer drug) with longer linker and substituted hydrophobic moiety using Ligand Designer from Glide (Schrodinger LLC). By experimenting with different amide and Schiff base residues, the linker was optimized. Using licensed Schrodinger modeling software, the probable inhibition over EGFR-TK for the best-designed items was virtually assessed. The findings demonstrated that there is a possibility of an acceptable level of fitness interaction between the h

Among the strong calcium channel blockers, lercanidipine hydrochloride (LER) has been shown to be useful in reducing blood pressure by acting on L-type calcium channels. Nevertheless, the main drawback of lercanidipine is that it is a BCS class II medication with poor solubility and a 10% oral bioavailability because of significant first pass metabolism. The goal of this study is to use the thin film hydration process to generate and assess lercanidipine nanomicelles utilizing soluplus in conjugation with other surfactants/polymers at different ratios in order to boost the solubility of virtually insoluble LER. Six formulations were prepared and analyzed for their micelles size, polydispersity index (PDI), encapsulation efficiency (EE%),

Because pathogenic bacteria have gained resistance, bacterial illnesses are difficult to treat. Every year, a huge number of studies aimed at creating novel antibacterials are released. Shiff bases are an important field in organic synthesis due to their biological activities. Schiff bases also possessing an important range of pharmacological activities. Hybridization-combing two pharmacophores [heterocycle from starting molecule and synthesized hydrazones]  to form one molecule-is the important method in designing new drugs. The new compounds [hydrazones] derivatives were created using a multi-step process including synthesis of  indomethacin hydrazide by coupling agent reaction (EDC.HCL,HOBt) and then reaction with defferent aldehyde

An intranasal drug delivery system offers a non-invasive, effective, reliable, direct, and alternative route to the CNS via the neural connections between the nasal mucosa and the brain. Paliperidone (PAL) is mainly used to treat schizophrenia and disorder. It’s practically insoluble in water class II with low bioavailability 28%. Therefore the aim of preparation of nano nasal suspension gel is in order to target PAL to brain via neural connections of nasal mucosa and the brain, and then enhance the uptake and bioavailability of the drug near and at the site of action. Different variables were investigated in this study, in order to recognize the best formula that aims the drug

Background: Paracetamol poisoning is a global issue that results in severe liver failure and permanent liver damage, necessitating the need for liver transplantation. The objective of our study was to assess and compare the preventive effects of Apigenin and vitexin against paracetamol-induced liver damage in rats.

Methods: Rats were divided into four groups and treated for seven consecutive days. Group I received 0.5% DMSO, Group II received a single paracetamol dose, and Groups III-IV received 10 mg/kg Apigenin or 40 mg/kg vitexin i.p for 7 days. On the seventh day, all groups except the Group I received a single oral dosage of 3000 mg/kg paracetamol three hours after their final Apigenin or vitexin dose. After 24 hours of parac

     The present work aims to formulate carvedilol as nanomicelle and study variables effect on the particle size of nanomicelle, and on the entrapment efficiency (EE%). The formulations were performed by two methods; thin film hydration method and direct dissolution method using soluplus® and polyvinylpyrrolidone (PVP K-25) as polymers. The results revealed that formulations prepared by direct dissolution method exhibits lower size and higher EE% as compared with thin film hydration method, it was found that soluplus® produces larger size of nanomicelle and lower EE% as compared with PVP K-25, it was found that as the amount of polymer raised, the size of nanomicelle increased in both polymers, the effect of solvent indicates that

The unique opportunity lies in targeting tumor cells through glycolysis, a pathway that compensates for decreased ATP production by increasing sugar consumption. This strategy allows for the development of a novel therapeutic approach, targeting malignant cells with selective pharmacological inhibitors of glycolysis without harming normal cells. In this study, hexokinase, glycolytic enzyme, was targeting to selectively inhibit energy production pathways in cancer cells without harming normal cells. The anticancer mechanisms of 2 Deoxy-D-Glucose (2DG) and Mannoheptulose (MH) in esophagus adenocarcinoma (SK-GT-4) and HBL-100 normal cell lines were investigated using MTT and wound healing assays to assess their cytotoxic effects and cellula

Doxorubicin is a potent anthracycline antibiotic used to treat many types of human neoplasms. The long-term adverse effect is cardiomyopathy, which is primarily caused by the extensive production of reactive oxygen species, which relates to several events related to nucleic acid metabolism and the activation of the immune system. Chromium is a trace element mostly utilized to regulate glucose levels and enhance the body's response to insulin, particularly in people with diabetes. Chromium picolinate often contains Chromium in its trivalent state, coupled with picolinic acid. The current study aims to evaluate the anti-inflammatory effect of chromium picolinate in doxorubicin-induced cardiotoxicity of rats. Twenty eight Wister male rats w

             One of the most potent and effective drugs in the field of chemotherapy is doxorubicin. It has shown remarkable efficacy against multiple cancer targets. Despite the effectiveness of this treatment, an important drawback is the cardiotoxicity caused by doxorubicin. This limitation has led oncologists to explore potential ways to prevent or reduce this toxic side effect. We will investigate in this study whether saxagliptin and telmisartan have any protective effects on heart tissue. We will study their effects on oxidative stress and apoptotic indicators in particular. There were a total of 28 rats, with 7 animals in each of the four groups: First group(control group): seven rats in good health were given distill

A novel glycine-based sulfonamide derivates were synthesized. This study presents the newly synthesized compounds (G1-G6) that exhibit promising DHPS inhibition activities, designed through a molecular docking analysis targeting the Yersinia pestis DHPS protein (PDB ID: 5JQ9). The docked compounds were subsequently subjected to ADME study to evaluate their pharmacokinetic properties. This work started with the synthesis of the glycine methyl ester HCL salt by esterification of the carbonyl group of the carboxylic acid functionality of glycine with thionyl chloride and methanol and the synthesis of 4-acetamidobenzene sulfonyl chloride from acetanilide, the reaction of the latter two intermediates using the TEA as base and neutralizing age

Among the many NSAIDs generated from phenyl acetic acid is Aceclofenac, or ACE. Its antipyretic, analgesic, and anti-inflammatory effects are noteworthy. However, the substance's delayed dissolution, limit permeability, and inadequate bioavailability are caused by its low solubility in water, which hinders its usefulness. Nanosponges (NS) are tiny particles with nanoscale holes and a distinctive three-dimensional nanostructure. The incorporation of both water-soluble and fat-soluble molecules into these hollow spaces enhances the efficacy and safety of medication delivery. This study aims to improve and advance the formulation of ACE-containing nanosponges. The emulsion solvent diffusion procedure is used to prepare the nanosponges that

Nimodipine (NID) is used for the prevention of ruptured intracranial aneurysms and subarachnoid haemorrhage (SAH). The objective of study using the benefits of a combined approach of polymeric nanoparticles and microneedles to fabricate NID as polymeric nanoparticles (NID-NPs) loaded in a bilayer dissolving microneedle (bDMNs) patch to enhance the delivery of drugs through skin layers as a promising noninvasive and painless delivery system, improving poor solubility and lower oral bioavailability (5–10%) owing to first-pass metabolism, which leads to frequent dosing, inconsistent clinical responses, and poor patient compliance. The NID-NPs formula was fabricated with a (1:8) drug to polymer, Soluplus®, w/w ratio and 0.25% polyvinylpyr

Nimodipine is a vasodilator medicinal agent approved for the prevention of cerebral vasospasm, a major risk factor that causes deaths in patients diagnosed with subarachnoid hemorrhage. The current marketed products of this drug are associated with challenges such as frequent dosing orally, or continuous infusion through central vein. Therefore, transdermal delivery of nimodipine via transferosomes can overcome these difficulties. Solvent evaporation-hydration method followed by sonication was applied for the preparation of transferosomes. The aim of present study is to investigate and optimize the processing parameters of this method through the utilization of Design-Expert software. Box-Behnken statistical design was selected for this