Chronic stable angina pectoris (CSAP) is a prevalent heart disease which can be defined as a symptom or a clinical syndrome of stable coronary artery disease (CAD). CAD is usually caused by the presence of atherosclerotic plaques or blood clot within coronary arteries that may lead to ischemia. miRNA 133a is mainly expressed in the muscle and it has a role in apoptosis, angiogenesis, hypertrophy, atherosclerosis and ischemia. MR-proADM is of endothelial origin and produced by different sites in the body mainly by the heart, kidneys, lungs and adrenal medulla. MR-proADM plasma level is thought to be predictive of CAD. The aim of the current study was to detect the serum levels of micr

One of the innovative approaches to delivering drugs via topical route is nanoemulation (NE), which is easy to manufacture, stable over the long term, and has a potent solubilization property. Pimecrolimus is a low water soluble drug used to treat psoriasis, eczema, atopic dermatitis and vitiligo. This work describes the high-energy ultrasonication technique used to prepare pimecrolimus nanoemulsion. A pseudo-ternary phase diagram was created in order to determine the ideal ratios of oil-surfactant/co-surfactant mixture for the creation of nanoemulsions. Based on pimecrolimus's solubility in various oils, surfactants, and co-surfactants, Tween 80 was chosen as a surfactant, ethanol as a co-surfactant, and benzyl alcohol as an oil phase .

           Isradipine is a calcium channel blocker, it’s the drug of choice for oral therapy of severe hypertension and urgent hypertension crises in pediatrics. It belongs to the BCS class II. Its oral bioavailability will be approximately 15 to 24 %.

          This study aims to prepare a stable, low-toxic, eco-friendly, surfactant-free oral oil-in-water emulsion of Isradipine for pediatric patients and enhance dosing accuracy. Isradipine surfactants–free emulsions (SFE) were prepared to protect this ester drug from hydrolysis, oxidation, photosensitivity, increasing its solubility and absorption, thereby improving its bioavailabi

The present study aims to facilitate the development of new agents with better properties specifically, we focus on modifying the basic structure of quinolones; by introducing new functionality at its C3 position. For this purpose, a series of new conjugation derivatives (IIa-Vb) were designed and synthesized by esterification of quinolones (ciprofloxacin, gatifloxacin, nalidixic acid and norfloxacin) with two types of antioxidants (a: menthol and b: umbelliferone) at their carboxylic group at the C3 position which was replaced by an ester group through a glycol linker. The synthesized compounds were checked and characterized for their purity and chemical structure by spectral techniques (NMR, ATR-FTIR) also they were examined for their

Antibody-drug conjugates (ADCs), a powerful type of pharmaceutical medications that combine immunotherapy and chemotherapy. Pemetrexed is a multitarget antifolate agent that inhibit essential enzymes involve in purine and pyrimidine synthesis, therefore serious toxicities of pemetrexed are due to lack of selectivity despite its broad antitumor activity in a wide variety of solid tumors. The aim of the study was to formulate and evaluate our prepared Atezolizumab (AtZ)-pemetrexed (Pem) conjugates as an intravenous (I.V) injectable dosage form. The characterization of the I.V formulation involved drug content, particle size, pyrogen test, sterility test, toxicity test, and stability test. The work revealed that our previously prepared

Dermatophytosis is the most common contagious fungal disease. Iraq, like the other many countries around the world, is facing an emergence of chronic, resistant and relapsing tinea infections. This study compared the efficacy, safety and the relapse rate of a combination therapeutic regimen of itraconazole and terbinafine vs. itraconazole alone in the treatment of chronic tinea infections. The research was conducted at the dermatology and venereology outpatient’s unit, Ramadi Teaching Hospital, Iraq, during the period from May 2022 to May 2023. Patients were divided equally into two groups. Group I received combination of itraconazole and terbinafine while group II was on itraconazole alone for eight weeks for each group. For assessmen

Disulfiram (DSF) is a thiocarbamate derivative that has been used for the treatment of alcoholism. Researchers recently found out that DSF, a medicine authorized by the FDA to prevent alcohol consumption, has been investigated for its potential in cancer treatment. DSF, when taken by mouth, undergoes extensive metabolism in the liver, making it unsuitable for cancer treatment via oral administration. Furthermore, DSF has demonstrated the ability to enhance the cytotoxic impact of anticancer medications while preserving healthy cells. To solve the problem of instability and insufficient therapeutic efficacy, invasomal vesicles developed with better entrapment efficiency and size to serve as a carrier for the transdermal delivery of disulf

The pigweed family, Amaranthaceae, includes Amaranthus viridis, popularly known as green amaranth. This herb grows quickly and has an annual lifespan. Traditionally, it has been used to treat anemia, eczema, bronchitis, inflammation, and leprosy. Additionally for respiratory issues, ocular conditions, and asthma.

The phytochemical analysis of Amaranthus viridis L extracts identifies the presence of several categories of biologically active substances (phytochemicals): phenolics, which include flavonoids, tannins, and phenolic acids. Alkaloids, cardiac glycosides, various classes of triterpenoids, and steroids were also found.

Numerous investigations on A. viridis have been conducted to explore i

The transdermal route of drug delivery has received significant attention in pharmaceutical research due to its ability to overcome many challenges associated with oral medication administration, including the ability to bypass first-pass metabolism, ensuring a more predictable and prolonged period of action, as well as minimizing the occurrence of adverse reactions. Transferosomes are a type of ultra-deformable lipid-based vesicles, that have the potential to offer several benefits compared to the traditional lipid-based vesicles such as liposome. The major goal of this research was to prepare (for the first time) dapagliflozin-loaded transferosomes for the purpose of minimizing the potential risk of hyperglycemia associated with oral a

Hepatic fibrosis is a pathophysiological outcome of sustained wound healing response to chronic liver injury charecterized by excessive accumulation of extracellular matrix proteins. Progressive liver fibrosis can be caused by chronic infection of hepatitis B or C, alcohol abuse, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, and other relatively conditions. Liver fibrosis, the subsequent cirrhosis represent a serious medical burden; yet, there is still a lack of approved methods or drugs t

Nanomicelles, a nanocarrier drug system, recently applied in medical research as a technique to deliver therapies to the targeted site. Normal nanomicelles building units are amphiphilic molecules (surfactants or polymers) containing hydrophobic tails and hydrophilic heads that self-assembled into the hydrophobic core-hydrophilic shell-like structure that dispersed into the aqueous media upon hydration. Polymeric nanomicelles had a lower critical micelle concentration by thousands of folds than surfactants of low molecular weight, resulting in a higher stability and circulation time after administration. Mixed nanomicelles have an extra advantage by improving the stability and encapsulation e

An oral bi layer  sustained release (SR) strips of Sodium  Montelukast SMLT , which is selective  leukotriene  antagonist  , used  for  patients  suffered from mid-night asthma , were prepared successfully ,using different polymers, like guar  gum , carrageenan , and xanthan gum , by solvent casting method .

The results obtained by this study revealed  ,that best  fast  dissolving  film of  SMLT was  loaded  in carrageenan   polymer 57%  w\w (30mg.) ,  with  acceptable  physical properties, like film thickness , elastic endurance and  surface pH  .

Besides  to that , the  disintegration  t

  COVID-19 disease is a clinical syndrome caused by an envelope RNA virus, called SARS-COV-2., which causes infection with wildly clinical pictures. Through COVID-19 infection several components of humoral and cellular immune response have an important role in the progression of the infection. Chemokines are one of the inflammatory mediators that play an essential role in the immune pathogenesis of COVID-19. It is secreted by respiratory virus-infected cells in the upper respiratory tract, causing stimulation and recruitment of inflammatory cells such as neutrophils, NK, eosinophils, and macrophages from the bloodstream to the site of the infection. This study strives to determine the impact role of inflammatory mediat

The exact mechanism of action and which rheumatoid arthritis (RA) patients might benefit from Rituximab (RTX) are still questionable. One of the key elements in assessing the performance of a healthcare facility is patient satisfaction, which is a measure of how satisfied a patient is with the medical care he receives. This study aimed to evaluate the health-related quality of life and treatment satisfaction and their association with the responsiveness to RTX in RA patients. A cross-sectional study was conducted at the Center of Rheumatology in Baghdad- Iraq. The study enrolled 90 patients diagnosed with RA and receiving RTX intravenous infusion, for at least six months. The 28-joints disease activity score (DAS28) and clinical disease

Microbial lipases today occupy a place of prominence among biocatalysts owing to their ability to catalyze awide variety of reactions in aqueous and non- aqueous media, A.baumannii were isolated from different clinical specimens from hospitalized patients from Baghdad hospitals and were detected by biochemical tests and API20E system. The percentage of isolation was (16.6%), A. baumannii is an increasingly multidrug – resistant (MDR), it showed high level of resistant to Ceftriaxon, Colistin, Piperacillin, Co-trimoxazol, Tertracycline, Carbenicillin, Amoxicillin, Penicillin G, Gentamicin and Ceftazidim , wherease the isolates were highly sensitive to Imipenem, Ciprofloxacin, Meropenem, Amikacin, and Cefotaxime.

   Ketoconazole (KET), an imidazole derivative with well-known antifungal properties, with poor aqueous solubility, therefore its topical clinical use has practical disadvantages. Bilosome plays an important role in topical drug delivery as they can reduce toxicity and modify dermal drug targeting by acting as a drug reservoir that can adjust the drug release rate.

This research aimed to formulate and optimize KET bilosomes to enhance its dissolution and topical antifungal activity. 

Ten KET bilosomes formulas were prepared by probe sonication method using two types of non-ionic surfactants (Span 40 or Span 60) along with cholesterol and sodium deoxycholate (SDC) as lipid strengthen and bil

              Cefdinir (CEF) is classified as a third-generation cephalosporin within class IV of the Biopharmaceutical Classification System (BCS). Consequently, it exhibits limited solubility in water, which might diminished oral bioavailability. This study aimed to compare CEF in different engineered product. Specifically, the CEF was physically mixed with co-former and then processed using different methods such as co-amorphous system formation with curcumin, binary solid dispersion with polyvinylpyrrolidone k30 (PVP) and with soluplus and ternary solid dispersion with curcumin and PVP using solvent evaporation method. The products were subjected to characterization usi

Background: The main mechanisms thought to be involved in the pathophysiology of acute renal failure with vancomycin treatment are oxidative stress, inflammation and apoptosis.  In this study we evaluated the potential effects of sulbutiamine, thiamine, riboflavin and their combinations on vancomycin-induced acute renal failure as well as the underlying mechanisms.

Methods: a model of vancomycin-induced acute renal failure was performed on male rats. Forty-two rats were separated randomly into seven groups:  group 1 (a control group), group 2 (induction vancomycin group) given 200mg/kg at 3^rd week, group 3 (sulbutiamine + vancomycin), group 4 (thiamine + vanc

Psidium guajava) is a compact tropical tree or shrub belonging to the Myrtaceae family. Originally native to tropical America, The literature survey has unveiled the diverse medicinal properties of guava, which have been documented worldwide through ethnobotanical and ethnopharmacological surveys so it is newly cultivated in Iraq, this research is considered the first of its kind to extract essential oil from guava leaves and fatty acid from petroleum ether fraction of guava leaves newly cultivated in Iraq to identify the compounds present and test the cytotoxic activity of petroleum ether fraction on HEPG2 cell line. The extraction of essential oil (EO) from (Guava) leaves was carried out using the hydro distil

Meclizine Hydrochloride (MCZ) is an effective antihistamine for the prevention and treatment of nausea and vomiting, with low oral bioavailability (about 30 to 40%) due to low water solubility. The purpose of the current study was to develop and characterize a thermo-responsive nasal in-situ gel for MCZ. To enhance the solubility of MCZ, an inclusion complex with Hydroxypropyl-β-Cyclodextrin (HP-β-CD) was prepared and characterized. The prepared complex was utilized in the preparation of thermosensitive in situ gels using the cold method. Twelve formulations were developed by employing various concentrations of Poloxamer 407, either alone or in combination with Poloxamer 188. Additionally, hydroxypropyl methylcellulos

         Cardiovascular disorders  are  refer to the class of diseases that involve the heart or blood vessels (arteries and veins). While the term technically refers to any disease that affects the cardiovascular system. Cholesterol is classified as a sterol (a contraction of steroid and

         Cosmetic products must be safe for use by consumers , It is also regulated and required the legislation of countries all over the world .  In this study out of 80 cosmetic products analyzed and 32.5% were found to be contaminated .Products such as mascara, lip pencil and eye pencil were analyzed . The contaminants including bacteria such as Staphylococcus aureus , Staphylocoocus epidermidis , Pseudomonas aeruginosa , Escherichia coli and Klebsiella pneumonia   which were ranging  in number  from (10³-10⁴ ) C.F.U. /ml and fungi such as Penicillium spp. , <

Background: The anticancer impact of Epigallocatechin gallate (EGCG) the highly active polyphenol of green tea was abundantly studied.  Though, the exact mechanism of its cytotoxicity is still under investigation. Objectives: Hence, the current study designed to investigate the molecular target of EGCG in HepG2 cells on thirteen autophagy- and/or apoptosis- related genes. Methods: The apoptosis detection analyses such as flow cytometry and dual apoptosis assay were used. The genes expression profile was explored by the real-time quantitative-PCR. Results: EGCG increases G0/G1 cell cycle arrest and the real-time apoptosis markers proteins leading to stimulate apoptos

The effect of mental and physical health on the feelings of subject welfare is known as health-related quality of life. The chronic obstructive pulmonary disease is a common respiratory diseases. Assessment of health-related quality of life is considered important in such chronic disease. The objective of the current study was to measure health-related quality of life in a sample of chronic obstructive pulmonary  patients in AL- Diwanyia city/Iraq. This study was carried out on 150 already diagnosed COPD patients who attended to the Center of Respiratory Diseases/AL-Diwaniyah Teaching Hospital during September  2019 to January 2020. The Arabic version of St George’s Respiratory Questionnaire was used to asses

Abstract

A sensitive, precise and reliable indirect spectrophotometric method for the determination of chlordiazepoxide (CDE) in pure and pharmaceutical dosage forms is described. The method is based on oxidative coupling reaction between amino group resulting from acidic decomposition of CDE with phenothiazine in the presence of sodium periodate to produce an intense green soluble dye that is stable and shows a maximum absorption at 602 nm. The calibration plot indicates that Beer’s law is obeyed over the concentration range of 0.1?50 µg/mL, with a molar absorptivity of 1×10⁴ L/mol cm and correlation coefficient of 0.9994.All the conditions that affecting on the stability and sensitivity of the fo

Abstract

     The development of antimicrobial resistance (AMR) is related mostly to their use, overuse, or misuse. Antimicrobial stewardship (AMS) refers to the interventions designed to measure and improve the appropriate use of antimicrobials by promoting the selection of the optimal antimicrobial drug, dose, duration of therapy, and route of administration. Community pharmacists are key health-care professionals for any AMS programs due to their role in dispensing of antimicrobials. This study aimed to evaluate the practices and perception of Iraqi community pharmacists regarding AMS. The present study was a cross-sectional online survey study that was conducted anonymously during two mont

The present work describes guggul as a novel carrier for some anti-inflammatory drugs. Guggulusomes containing different concentration of guggul with aceclofenac were prepared by sonication method and characterized for vesicle shape, size, size-distribution, pH, viscosity, spread ability, homogeneity, and accelerated stability in-vitro drug permeation through mouse skin. The vesicles exhibited an entrapment efficiency of 93.2 ± 12%, vesicle size of 0.769 ± 3μm and a zeta potential of - 6.21mV. In vitro drug release was analyzed using Franz’s diffusion cells. The cumulative release of the guggulusomes gel (G2) was 75.8% in 18 hrs, which is greater than that all the gel formulation. The stability profile of prepare

Osteoporosis (OP)is one of the most important metabolic disorder also affected by interaction of genetic and environmental factors by almost 70% and 30% respectively. Genetic components are identified to strongly effect bone mineral density, bone building and turnover, so they play an important role in determining risk of OP and fragility fractures. This study consists of patient and control group; Group A: (70) postmenopausal women with OP and osteopenia, Group B: (20) control group.  five milliliters of blood sample were divided into three tubes; one tube (1ml) contain gel for obtain serum to measure glucose level, the others tubes containing ethylene-diamine-tetra-acetic acid (EDTA), in 2 tube 2ml stored in deep freeze at (–40

3-coumarin/chalcone B1/B2/B3 hybrids served as malleable antecedents for the development of novel bioactive pharmacophores. In this study, the matching coumarin-chalcones hybrid was obtained from 3-acetylcoumarin (comp A) via condensation with several aromatic aldehydes in ethanolic piperidine solution. To further modify these hybrids, we reacted them with thiourea in the presence of base in ethanol, yielding pyrimidine derivatives C1, C2, and C3. Their chemical characteristics and spectroscopic data were used to characterize the newly synthesized heterocyles. The antibacterial efficacy of all freshly produced compounds was tested. Compound (C3) was shown to have the highest antibacterial activity against both gram positive and gram nega